A5019153486- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Primary Care and Health Outcomes
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Chronic Disease Management Strategies
- Healthcare Policy and Management
- Lipoproteins and Cardiovascular Health
- Interprofessional Education and Collaboration
- Diabetes Management and Research
- Metabolism, Diabetes, and Cancer
- Health Systems, Economic Evaluations, Quality of Life
- Health Policy Implementation Science
- Diet and metabolism studies
- Peroxisome Proliferator-Activated Receptors
- Lipid metabolism and disorders
- Lipid metabolism and biosynthesis
- Liver Disease Diagnosis and Treatment
- Emergency and Acute Care Studies
- Diabetes and associated disorders
- Geriatric Care and Nursing Homes
- Antioxidant Activity and Oxidative Stress
- Global Health Care Issues
- Cardiovascular Disease and Adiposity
- IL-33, ST2, and ILC Pathways
- Mobile Health and mHealth Applications
National University of Singapore
2016-2025
National University Health System
2015-2025
National University Hospital
2012-2024
University of Pennsylvania
2008-2020
SingHealth
2020
University Health System
2017-2020
Regional Health
2018
Duke-NUS Medical School
2016-2017
Translational Therapeutics (United States)
2008-2011
Tissue macrophages have a split personality Resident tissue (RTMs) reside in various tissue-specific niches during development. They evince microenvironment-directed phenotypes that support host defense and homeostasis. Chakarov et al. used single-cell RNA sequencing fate-mapping of murine lung RTMs to interrogate RTM-subset heterogeneity, interrelationships, ontogeny (see the Perspective by Mildner Yona). In addition alveolar macrophages, they identified two different interstitial...
Nonalcoholic fatty liver disease (NAFLD) is highly prevalent in patients with type 2 diabetes mellitus (T2DM) and associated significant morbidity mortality. Thyroid hormone (TH) increases β-oxidation of acids decreases intrahepatic lipid content (IHLC) rodents NAFLD. We investigated the possibility low TH concentration NAFLD studied effect treatment humans. This was a phase 2b single-arm study six hospitals Singapore. Intrahepatic thyroid concentrations were measured rats induced Euthyroid...
Abstract The Simpson Golabi Behmel Syndrome (SGBS) pre-adipocyte cell strain is widely considered to be a representative in vitro model of human white pre-adipocytes. A recent study suggested that SGBS adipocytes exhibit an unexpected transient brown phenotype. Here, we comprehensively examined key differences between and primary subcutaneous (PHWSC) adipocytes. RNA-Seq analysis revealed extracellular matrix (ECM)-receptor interaction metabolic pathways were the top two KEGG significantly...
Abstract Key to realizing the diagnostic and therapeutic potential of human brown/brite adipocytes is identification a renewable, easily accessible safe tissue source progenitor cells an efficacious in vitro differentiation protocol. We show that macromolecular crowding (MMC) facilitates brown adipocyte adult bone marrow mesenchymal stem (bmMSCs), as evidenced by substantially upregulating uncoupling protein 1 (UCP1) uncoupled respiration. Moreover, MMC also induced ‘browning’ bmMSC-derived...
Introduction The lack of understanding how complex integrated care programmes achieve their outcomes due to the acceptable methods leads difficulties in development, implementation, adaptation and scaling up similar interventions. In this study, we evaluate an network, National University Health System (NUHS) Regional (RHS), consisting acute hospitals, step down care, primary providers, social services community partners using a theory-driven realist evaluation approach. This study aims...
High utilizers (HUs) are a small group of patients who impose disproportionately high burden on the healthcare system due to their elevated resource use. Identification persistent HUs is pertinent as interventions have not been effective regression mean in majority patients. This study will use cost and utilization metrics segment hospital-based patient population into HU groups.The index visit for each adult an Academic Medical Centre Singapore during 2006 2012 was identified. Cost, length...
Increased visceral fat, rather than subcutaneous during the onset of obesity is associated with a higher risk developing metabolic diseases. The inherent adipogenic properties human adipose-derived stem cells (ASCs) from depots are compromised compared those ASCs depots, but little known about underlying mechanisms. Using ontological analysis global gene expression studies, we demonstrate that many genes involved in retinoic acid (RA) synthesis or regulated by RA differentially expressed...
It is known that the macronutrient content of a meal has different impacts on postprandial satiety and appetite hormonal responses. Whether obesity interacts with such nutrient-dependent responses not well characterized. We examined after high-protein (HP), high-carbohydrate (HC), or high-fat (HF) mixed meal. This was randomized cross-over study 9 lean insulin-sensitive (mean±SEM HOMA-IR 0.83±0.10) obese insulin-resistant (HOMA-IR 4.34±0.41) young (age 21–40 years), normoglycaemic Chinese...
To cope with rising demand for healthcare services in Singapore, Regional Health Systems (RHS) comprising of health and social care providers across settings were set up to integrate service delivery. Tasked providing the western region, 2012, National University System (NUHS) – RHS developed a transitional program elderly patients complex needs who consumed high levels hospital resources. Through assessment, development personalized plans coordination, aimed to: (i) improve quality care,...
Aims/hypothesisPrediabetes and type 2 diabetes are highly prevalent in Asia. Understanding the pathophysiology of abnormal glucose homeostasis Asians will have important implications for reducing disease burden, but there been conflicting reports on relative contributions insulin secretion action progression. In this study, we aimed to assess contribution β-cell dysfunction resistance Asian prediabetes phenotype.MethodsWe recruited 1679 with (n = 659) or normoglycemia 1020) from a...
Introduction The population is heterogeneous with varying levels of healthcare needs. Clustering individuals into health segments more homogeneous needs allows for better understanding and monitoring profiles in the population, which can support data-driven resource allocation. Methods Using developed criteria, data from several Singapore’s national administrative datasets were used to classify various segments. Cross-sectional analysis utilization charges was conducted. Validation done...
Apolipoprotein F (ApoF) is a protein component of several lipoprotein classes including HDL. It also known as lipid transfer inhibitor (LTIP) based on its ability to inhibit between lipoproteins ex vivo. We sought investigate the role ApoF in HDL metabolism.Adeno-associated viruses (AAV) serotype 8, were used overexpress either murine or human mice. Overexpression significantly reduced total cholesterol levels by 28% (P<0.001), 27% and phospholipid 19% (P<0.001). had similar effects. Human...
Historically, diabetes is diagnosed by measuring fasting (FPG) and two-hour post oral glucose load (OGTT) plasma concentration interpreting it against recommended clinical thresholds of the patient. More recently, glycated haemoglobin A1c (HbA1c) has been included as a diagnostic criterion. Within-individual biological variation (CVi), analytical (CVa) bias test can impact on accuracy reproducibility classification disease. A with large increases likelihood erroneous underlying disease state...
The Ministry of Health (MOH) has updated the Clinical Practice Guidelines on Lipids to provide doctors and patients in Singapore with evidence-based treatment for lipids. This article reproduces introduction executive summary (with recommendations from guidelines) MOH Lipids, information SMJ readers. Chapters page numbers mentioned reproduced extract refer full text guidelines, which are available website:...
Transient receptor potential (TRP) channels are polymodal cell sensors responding to diverse stimuli and widely implicated in the developmental programs of numerous tissues. The evidence for an involvement TRP family members adipogenesis, however, is scant. We present first comprehensive expression profile all known 27 human genes mesenchymal progenitors cells during white or brown adipogenesis. Using positive trilineage differentiation as exclusion criterion, polycystic (P)3, TPR melastatin...
In Singapore, a densely urbanised Asian city state, more than 80% of the population stays in public housing estates and majority (90%) own their homes. For needy who cannot afford home ownership, rental flats are available. We were interested exploring social-environmental factors that associated with loneliness among elderly residents Singapore. surveyed aged ≥60 two Singapore precincts 2016. Loneliness was measured using three-item scale. Sociodemographic information obtained via...