A5066365214- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes Treatment and Management
- Chronic Kidney Disease and Diabetes
- Cardiovascular Health and Disease Prevention
- Diabetes Management and Research
- Diabetes Management and Education
- Liver Disease Diagnosis and Treatment
- Diet and metabolism studies
- Blood Pressure and Hypertension Studies
- Chronic Disease Management Strategies
- Lipid metabolism and disorders
- Clusterin in disease pathology
- Metabolism, Diabetes, and Cancer
- Lipoproteins and Cardiovascular Health
- Nutrition and Health in Aging
- Pancreatic function and diabetes
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Function and Risk Factors
- Nutritional Studies and Diet
- Muscle metabolism and nutrition
- Obesity, Physical Activity, Diet
- Retinal Diseases and Treatments
- Diabetes and associated disorders
- Bariatric Surgery and Outcomes
- Advanced Glycation End Products research
Khoo Teck Puat Hospital
2016-2025
National University of Singapore
2008-2021
National University Health System
2021
National University Hospital
2021
Mount Elizabeth Hospital
2020
Kidney Health Australia
2019
Zhaotong University
2019
National Cancer Registry
2019
Clinical Nutrition Research Centre
2015
Nanyang Technological University
2015
Dysregulation of microRNA (miRNA) expression in various tissues and body fluids has been demonstrated to be associated with several diseases, including Type 2 Diabetes mellitus (T2D). Here, we compare miRNA profiles different (pancreas, liver, adipose skeletal muscle) as well blood samples from T2D rat model highlight the potential circulating miRNAs biomarkers T2D. In parallel, have examined Impaired Fasting Glucose (IFG) male patients.Employing microarray stem-loop real-time RT-PCR,...
Coordinated interplay of dysregulated microRNAs in isolated metabolic disorder is implicated the pathogenesis syndrome.The objective study was to characterize microRNA expression blood and exosomes individuals with syndrome compare them those manifesting one vascular risk factors (type 2 diabetes, hypercholesterolemia, or hypertension). RESEARCH DESIGN/SETTING/PARTICIPANTS: A total 265 participants were recruited a health screening characterized into distinct groups as follows: 1) healthy...
Metabolic profiling of small molecules offers a snapshot physiological processes. To identify metabolic signatures associated with type 2 diabetes and impaired fasting glucose (IFG) beyond differences in glucose, we used mass spectrometry-based profiling.Individuals attending an institutional health screen were enrolled. IFG (n = 24) was defined as (FG) 6.1 to 6.9 mmol/L 2-hour post load <11.1 or glycosylated hemoglobin <6.5%, 27), FG ≥7.0 mmol/L, ≥11.1 ≥6.5%, healthy controls 60), <6.1...
Nonalcoholic fatty liver disease (NAFLD) is highly prevalent in patients with type 2 diabetes mellitus (T2DM) and associated significant morbidity mortality. Thyroid hormone (TH) increases β-oxidation of acids decreases intrahepatic lipid content (IHLC) rodents NAFLD. We investigated the possibility low TH concentration NAFLD studied effect treatment humans. This was a phase 2b single-arm study six hospitals Singapore. Intrahepatic thyroid concentrations were measured rats induced Euthyroid...
Abstract Background Physical inactivity and sedentary behaviour have detrimental consequences to the individual economy. Our study examined prevalence of perceived barriers physical activity in Singapore’s adult population their associations with behaviour. Methods This cross-sectional analysis utilised data from a nationwide survey Singapore. Participants ( n = 2867) were recruited February 2019 March 2020. The independent variables internal (e.g. fatigue, age) external weather, cost)...
Abstract Background Social desirability bias is one of the oldest forms response studied in social sciences. While individuals may feel need to fake good or bad answers sensitive intrusive questions, it remains unclear how rampant such a epidemiological research pertaining self-reported lifestyle indicators multicultural Asian context. The main purpose current study is, therefore, examine sociodemographic correlates and impact responding on physical activity dietary habits at an scale...
OBJECTIVE We sought to study the associations between plasma metabolites in tryptophan-kynurenine pathway and risk of progression end-stage kidney disease (ESKD) patients with type 2 diabetes. RESEARCH DESIGN AND METHODS Plasma tryptophan, kynurenine, 3-hydroxykynurenine, kynurenic acid, xanthurenic acid concentrations were measured discovery (n = 1,915) replication 346) cohorts. External validation was performed Chronic Renal Insufficiency Cohort (CRIC) participants diabetes 1,312). The...
Abstract Aim: The aim of this study was to investigate the relationship between markers metabolic control and inflammation periodontal disease parameters in patients with diabetes. Material & Methods: One hundred eighty one adult diabetes attending treatment at two centres were invited participate study. Periodontal examination included full‐mouth assessment for probing depths bleeding on (BOP). Blood analyses carried out glycated haemoglobin, (HbA1c), high‐sensitivity C reactive...
We determined the reliability and validity of Center for Epidemiologic Studies Depression Scale (CES-D) against DSM-IV-based diagnostic inventory, Schedule Clinical Assessment in Neuropsychiatry (SCAN), a multiethnic sample adult subjects with diabetes attending center Singapore.A total 522 (74.7% Chinese, 11.1% Malay, 14.2% Indian) completed culturally adapted versions CES-D; 291 were administered SCAN inventory.The CES-D (cutoff score 16) showed high negative predictive values more than...
Increased arterial stiffness and endothelial dysfunction are associated with peripheral disease (PAD). Leucine-rich-α2-glycoprotein (LRG1) is a proangiogenic factor involved in regulation of the TGFβ signaling pathway.This study patients type 2 diabetes mellitus explored associations plasma LRG1 stiffness, function, PAD.Based on ankle brachial index (ABI), were classified as having PAD (ABI ≤ 0.9) or being borderline abnormal (ABI, 0.91-0.99) normal 1.00-1.40). was measured by immunoassay;...
Pathophysiology of diabetic kidney disease (DKD) is incompletely understood. We aim to elucidate metabolic abnormalities associated with DKD in type 2 diabetes mellitus (T2DM) by targeted plasma metabolomics.A total 126 T2DM participants early (urinary albumin-to-creatinine ratio [ACR] 30-299 mg/g and eGFR ≥ 60 ml/min/1.73 m2), 154 overt (ACR 300 or < 129 non-DKD controls 30 m2) were included discovery study. Findings subsequently validated 149 macroalbuminuria mg/g) matched controls. Plasma...
Millions of Muslim patients with diabetes mellitus (DM) fast during Ramadan. However, little is known about the metabolic impact Ramadan fasting. We aimed to study changes in body composition and profile this group patients.We studied 29 Southeast Asian type 2 diabetes; all underwent pre-Ramadan education. Study variables were weight change, (using multifrequency bioimpedance method, InBody S20®, Biospace, South Korea), blood pressure (BP), glycated haemoglobin (HbA1c), fasting lipid...
Diabetes mellitus (DM) is a major cause of chronic kidney disease (CKD). The epidemiology CKD secondary to type 2 DM (T2DM) (i.e. diabetic nephropathy (DN)) has not been well studied in Singapore, multi-ethnic Asian population. We aimed determine the prevalence adult patients with T2DM.We conducted cross-sectional study on (n = 1861) aged 21 89 years T2DM who had attended centre single acute care public hospital or primary polyclinic between August 2011 and November 2013. Demographic...
Health literacy is a key determinant of the public health and climate nation. This study examined functional nation, factors associated with literacy, its relationship diabetes recognition. cross-sectional survey recruited participants (N = 2895) who were 18 years above from population registry through disproportionate stratified sampling. The Brief Literacy Screen other questionnaires administered face-to-face interviews, in one four national languages (English, Chinese, Malay or Tamil)....
The association between sodium-glucose cotransporter-2 inhibitors (SGLT2i) use and cognitive function in type 2 diabetes remains unclear.Explore the SGLT2i longitudinal changes adults with (T2DM) assessed domains which were impacted by SGLT2i.We conducted a prospective cohort study of 476 patients aged 60.6±7.4 years follow-up period up to 6.4 years. Data on was derived from questionnaire verified clinical database. We used Repeatable Battery for Assessment Neuropsychological Status (RBANS)...
Patients with younger onset of type 2 diabetes (YT2D) have increased risk for kidney failure compared to those late onset. However, the mechanism diabetic disease (DKD) progression in this high-risk group is poorly understood.
A stepped intravenous metformin infusion was used in conjunction with the hyperglycaemic clamp technique to study dose‐response relationship of plasma concentration hepatic glucose production and peripheral disposal nine patients Type 2 diabetes. The double‐blind crossover design, using NaCl as control. Plasma concentrations spanning therapeutic range (1.64 ± 0.13 mg I −1 6.57 0.61 ) were achieved. No differences demonstrated when compared (3.4 0.1 vs 3.6 0.2 (±SE) kg min 3.4 3.3 ,...
Diabetes mellitus (DM) is a serious chronic illness that has major impact on the quality of life individuals. Our aim was to examine determinants health-related (HRQOL) in patients with DM.Adult outpatients attending Centre were recruited consecutive basis between August 2006 and February 2007. Clinical data collected from interviews subjects medical records. Assessment depressive symptoms done using Center for Epidemiologic Studies Depression Scale (CES-D) HRQOL Short Form 36 Health Survey...