A5049223166- COVID-19 Clinical Research Studies
- COVID-19 and healthcare impacts
- SARS-CoV-2 and COVID-19 Research
- COVID-19 epidemiological studies
- COVID-19 and Mental Health
- Infection Control and Ventilation
- Long-Term Effects of COVID-19
- Health disparities and outcomes
- Respiratory viral infections research
- SARS-CoV-2 detection and testing
- Health Promotion and Cardiovascular Prevention
- Vaccine Coverage and Hesitancy
- Pneumonia and Respiratory Infections
- Migration, Aging, and Tourism Studies
- Disaster Response and Management
- Stroke Rehabilitation and Recovery
- Mosquito-borne diseases and control
- COVID-19 diagnosis using AI
- Antifungal resistance and susceptibility
- Antibiotic Use and Resistance
- Chronic Disease Management Strategies
- Infectious Encephalopathies and Encephalitis
- Amoebic Infections and Treatments
- Emergency and Acute Care Studies
- Viral Infections and Outbreaks Research
National Centre for Infectious Diseases
2023-2025
National University of Singapore
2010-2025
Nanyang Technological University
2024-2025
Singapore General Hospital
2016-2025
Duke-NUS Medical School
2018-2025
SingHealth
2016-2025
SingHealth Duke-NUS Academic Medical Centre
2024
Changi General Hospital
2021
National Heart Centre Singapore
2020
National University Health System
2010-2019
In the current COVID-19 pandemic, aggressive Infection Prevention and Control (IPC) measures have been adopted to prevent health care-associated transmission of COVID-19. We evaluated impact a multimodal IPC strategy originally designed for containment on rates other hospital-acquired-infections (HAIs).
Patients with COVID-19 may present respiratory syndromes indistinguishable from common viruses. This poses a challenge for early detection during triage in the emergency department (ED). Over 3-month period, our ED aimed to minimize nosocomial transmission by using broader suspect case criteria better and appropriate personal protective equipment (PPE) health care workers (HCWs).
Abstract Objective: Staff surveillance is crucial during the containment phase of a pandemic to help reduce potential healthcare-associated transmission and sustain good staff morale. During an outbreak SARS-COV-2 with community transmission, our institution used integrated strategy for early detection COVID-19 cases among healthcare workers (HCWs). Methods: Our comprised 3 key components: (1) enforcing reporting HCWs acute respiratory illness (ARI) institution’s clinic monitoring; (2)...
In the ongoing COVID-19 pandemic caused by novel coronavirus, SARS CoV-2, early isolation of hospitalized inpatients with suspected is important to reduce likelihood nosocomial spread. However, patients may present respiratory syndromes indistinguishable from those common viruses [[1]Guan W.J. Ni Z.Y. Hu Y. Liang W.H. Ou C.Q. He J.X. et al.Clinical characteristics coronavirus disease 2019 in China.N Engl J Med. 2020; ([Epub ahead print])https://doi.org/10.1056/NEJMoa2002032Crossref Scopus...
Abstract Background Growing evidence suggests that some coronavirus disease 2019 (COVID-19) survivors experience a wide range of long-term postacute sequelae. We examined the risk and burden new-incident cardiovascular, cerebrovascular, other thrombotic complications after severe acute respiratory syndrome 2 (SARS-CoV-2) infection in highly vaccinated multiethnic Southeast Asian population, during Delta predominance. Methods This cohort study used national testing healthcare claims databases...
<b><i>Background/Aims:</i></b> Neighborhood socioeconomic status (SES) can affect cognitive function. We assessed function and impairment among community-dwelling elderly in a multi-ethnic urban low-SES Asian neighborhood compared them with higher-SES neighborhood. <b><i>Methods:</i></b> The study population involved all residents aged ≥60 years two housing estates comprising owner-occupied (higher SES) rental flats (low Singapore 2012....
Hospitalisations for acute exacerbations of COPD (AECOPD) carry significant morbidity and mortality. Respiratory viral infections (RVIs) are the most common cause AECOPD associated with worse clinical outcomes. During COVID-19 pandemic, public health measures, such as social distancing universal masking, were originally implemented to reduce transmission SARS-CoV-2; these measures subsequently also observed other circulating RVIs. In this study, we report a sustained decrease in hospital...
Abstract Objectives: Patients with COVID-19 may present respiratory syndromes indistinguishable from those caused by common viruses. Early isolation and containment is challenging. Although screening all patients symptoms for has been recommended, the practicality of such an effort yet to be assessed. Methods: Over a 6-week period during SARS-CoV-2 outbreak, our institution introduced “respiratory surveillance ward” (RSW) segregate in designated areas, where appropriate personal protective...
During an ongoing outbreak of COVID-19, unsuspected cases may be housed outside dedicated isolation wards.At a Singaporean tertiary hospital, individuals with clinical syndromes compatible COVID-19 but no epidemiologic risk were placed in cohorted general wards for testing. To mitigate risk, infection control bundle was implemented comprising infrastructural enhancements, improved personal protective equipment, and social distancing. We assessed the impact on environmental contamination...
Abstract Background Literature on long-term real-world vaccine effectiveness of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) booster vaccines (up to and beyond 360 days) is scarce. We report estimates protection against symptomatic infection, emergency department (ED) attendances hospitalizations up days post-receipt messenger RNA (mRNA) among Singaporeans aged ≥60 years during an Omicron XBB wave. Methods conducted a population-based cohort study including all with no...
Abstract Background Data on protection afforded by updated coronavirus disease 2019 (COVID-19) vaccines (bivalent/XBB 1.5 monovalent) against the emergent JN.1 variant remain limited. Methods We conducted a retrospective population-based cohort study among all boosted Singaporeans aged ≥18 years during COVID-19 wave predominantly driven JN.1, from 26 November 2023 to 13 January 2024. Multivariable Cox regression was used assess risk of severe acute respiratory syndrome 2 (SARS-CoV-2)...
Abstract Background Individuals with heart failure (HF) / ischemic disease (IHD) have poorer outcomes following respiratory viral infections; however, data is lacking on and Vaccine Effectiveness (VEs) SARS-CoV-2 infection newer COVID variants. Methods Outcomes of Delta/Omicron in a highly vaccinated/boosted cohort adult Singaporeans HF/IHD were contrasted against matched population controls. Matching was conducted based age, sex, ethnicity, socioeconomic status, comorbidities. Cox...
Abstract Background Aspergillus species is an opportunistic mould associated with serious complications, healthcare costs and mortality, especially in immunocompromised patients. WHO has declared fumigatus as a “critical pathogen”. This study aims to report clinical epidemiology of patients Singapore General Hospital (SGH), acute-care hospital.Table 1:Demographic characteristics Methods Inpatients laboratory-confirmed were included this retrospective, observational between January 2018 April...
Long-term postacute sequelae following SARS-CoV-2 infection in children have been extensively documented. However, while persistence of chronic symptoms pediatric dengue has documented small prospective cohorts, population-based studies are limited. We evaluated the risk multisystemic complications contrast to that after a multiethnic Asian population. This retrospective cohort study utilized national COVID-19/dengue registries construct cohorts Singaporean aged 1 17 years with either...
This cohort study estimates the risk of new-onset type 2 diabetes after Delta or Omicron variant SARS-CoV-2 infection among vaccinated adults in Singapore.