A5033174535- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Ferroptosis and cancer prognosis
- Mesenchymal stem cell research
- RNA modifications and cancer
- Gastrointestinal motility and disorders
- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
- Extracellular vesicles in disease
- Epigenetics and DNA Methylation
- Reproductive System and Pregnancy
- Liver Disease Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Pregnancy and preeclampsia studies
- Gut microbiota and health
- Endoplasmic Reticulum Stress and Disease
- Ginseng Biological Effects and Applications
- Ovarian function and disorders
- COVID-19 Clinical Research Studies
- Pancreatic and Hepatic Oncology Research
- PI3K/AKT/mTOR signaling in cancer
- Pancreatitis Pathology and Treatment
- Telomeres, Telomerase, and Senescence
- Adipose Tissue and Metabolism
Chongqing Medical University
2018-2025
Wuhan University
2011-2025
Renmin Hospital of Wuhan University
2010-2025
China Medical University
2025
Longgang Central Hospital
2025
National Centre for Infectious Diseases
2025
Wuhan University of Science and Technology
2014-2024
Shanghai Pulmonary Hospital
2021-2023
Tongji University
2021-2023
Shanghai Changzheng Hospital
2022-2023
Polycystic ovary syndrome (PCOS) is a primary endocrine disorder affecting premenopausal women involving metabolic dysregulation. We aimed to screen serum biomarkers in PCOS patients using untargeted lipidomics and ensemble machine learning. Serum from non-PCOS subjects were collected for analysis. Through analyzing the classification of differential lipid metabolites association between clinical indexes, learning, data preprocessing, statistical test pre-screening, learning method secondary...
We have shown that bone marrow (BM)-derived mesenchymal stem cells (BM-MSCs) from SLE patients exhibit senescent behavior and are involved in the pathogenesis of SLE. The aim this study was to investigate effects rapamycin (RAPA) on senescences immunoregulatory ability MSCs MRL/lpr mice underlying mechanisms. Cell morphology, senescence associated β-galactosidase (SA-β-gal) staining, F-actin staining were used detect cells. BM-MSCs purified CD4+ T co-cultured indirectly. Flow cytometry...
Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women reproductive age. miR-93-5p has been reported to be elevated granulosa cells PCOS patients. However, mechanism by which drives cell (GC) progression remains unclear. Thus, this study focuses on roles and mechanisms GCs PCOS. Methods KGN have similar ovarian physiological characteristics are used function regulatory GCs. In study, were transfected with si-NC, si-miR93-5p, oe-NC oe-miR93-5p. A counting...
Abstract Dental pulp stem cells (DPSCs) are a type of mesenchymal (MSCs) characterised by self‐renewal and multi‐lineage differentiation, including chondrocytes, adipocytes, neural osteoblasts, which make it an attractive choice for tissue engineering purposes. Tumour necrosis factor α (TNF‐α) had the positive effect on mineralisation bone marrow MSCs stromal derived from human adipose tissue. However, TNF‐α DPSCs is unclear. We found that activated NF‐κB pathway during osteogenic...
The prevalence of psychological problems is frequent in systemic lupus erythematosus (SLE) patients and appears to be increasing. current study investigated the relationship among disease parameters, quality life, status Chinese with SLE. A self-report survey design was administered 170 SLE 210 healthy individuals using Self-Rating Anxiety Scale, Depression Short Form 36 health (SF-36). Our results showed that 20.3% had anxiety, 32.9% depression, which were significantly higher than control...
Background: Early detection of infected patients is one the most important steps to mitigate spreading 2019 novel coronavirus (2019-nCoV). Here, we report a set atypical 2019-nCoV pneumonia cases with gastrointestinal symptoms onset but without fever or other respiratory symptoms.Methods: We retrospectively reviewed data admitted only digestive and no on from January 17-24, in Renmin Hospital Wuhan University. The patients' history, clinical features, physical findings, complete blood count,...
Considerable evidence implicates myeloid-derived suppressor cells (MDSCs) promote tumor progression and drug resistance. Sorafenib is the standard first-line therapy for advanced hepatocellular carcinoma (HCC). Clinical indicates that sorafenib resistance associated with increased MDSCs, by which MDSCs exerts these effects obscure. This study aimed to investigate mechanism of mediated MDSCs. A syngeneic mouse-liver cancer cell line BNL was subcutaneously injected build a tumor-bearing mouse...
Abstract Objective The study's objective was to explore whether early time‐restricted eating (eTRE) and late (lTRE) have different impacts on intrahepatic fat metabolic health among patients with nonalcoholic fatty liver disease (NAFLD). Methods This is an 8‐week, randomized, parallel‐arm, open‐label trial. Forty eligible were randomly assigned eTRE (eating between 8:00 a.m. 4:00 p.m.) or lTRE 12:00 p.m. p.m.). primary outcome the change of measured by magnetic resonance image‐derived proton...
Our and other groups have found that bone marrow-derived mesenchymal stem cells (BM-MSCs) from systemic lupus erythematosus (SLE) patients exhibited senescent behavior are involved in the pathogenesis of SLE. Numerous studies shown activation p53/p21 pathway inhibits proliferation BM-MSCs. The aim this study was to determine whether is regulating aging BM-MSCs SLE underlying mechanisms. We further confirmed showed characteristics senescence. expressions p53 p21 were significantly increased,...
Background: An outbreak and worldwide spread of COVID-19 was derived from Wuhan, China where over half the confirmed cases were reported. Protection for special populations at high infection risk such as patients with inflammatory bowel diseases (IBD) is extremely urgent challenging. Methods: We kept alerts since first reported case started to send educational instructional took measures 318 registered IBD (204 UC 114 CD) 20 days earlier shutdown Wuhan. The patients' risks, responses our...
Emerging evidence has pointed out the importance of long non-coding RNAs (lncRNAs) in multiple diseases, knowledge rheumatoid arthritis (RA)-associated lncRNAs remains limited. In this present study, we aimed to elucidate mechanism lncRNA nuclear paraspeckle assembly transcript 1 (NEAT1) from peripheral blood monouclear cell (PBMC)-derived exosomes (exos) on RA development by modulating microRNA-23a (miR-23a)/murine double minute-2 (MDM2)/Sirtuin 6 (SIRT6) axis. was modeled vivo collagen...
Bone marrow-derived mesenchymal stem cells (MSCs) from systemic lupus erythematosus patients (SLE-BMSCs) exhibited abnormalities in cytokine production and immune modulation. Deregulation of Nod-like receptor pyrin domain-containing protein 3 (NLRP3) inflammasome plays an important role SLE. Herein, we explored whether miRNAs are involved the regulation NLRP3 SLE-BMSCs. ELISA assay was used to detect levels inflammatory cytokines. The expression let-7f-5p gene mRNAs were determined by...
Background and Objective: Acute kidney injury (AKI) is a complication of sepsis. Pyroptosis gasdermin D (GSDMD)-mediated tubular epithelial cells (TECs) play important roles in pathogenesis sepsis-associated AKI. Long non-coding RNA (lncRNA) maternally expressed gene 3 ( MEG3 ), an imprinted involved tumorigenesis, implicated pyroptosis occurring multiple organs. Herein, we investigated the role mechanisms regulation TEC lipopolysaccharide (LPS)-induced Materials Methods: Male C57BL/6 mice...