A5100726986- Systemic Lupus Erythematosus Research
- Rheumatoid Arthritis Research and Therapies
- Spondyloarthritis Studies and Treatments
- Gout, Hyperuricemia, Uric Acid
- Mesenchymal stem cell research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Extracellular vesicles in disease
- Autoimmune and Inflammatory Disorders Research
- Inflammasome and immune disorders
- Systemic Sclerosis and Related Diseases
- Salivary Gland Disorders and Functions
- Meningioma and schwannoma management
- MicroRNA in disease regulation
- Cytokine Signaling Pathways and Interactions
- Pituitary Gland Disorders and Treatments
- Bone and Dental Protein Studies
- Urticaria and Related Conditions
- Atherosclerosis and Cardiovascular Diseases
- Bone Metabolism and Diseases
- Peripheral Neuropathies and Disorders
- Oral Health Pathology and Treatment
- Immune Response and Inflammation
- Sleep and related disorders
- TGF-β signaling in diseases
- Tryptophan and brain disorders
Affiliated Hospital of Nantong University
2016-2025
Nantong University
2016-2025
Yinchuan First People's Hospital
2025
Dalian Medical University
2025
Shijiazhuang Tiedao University
2023-2024
Institut Pasteur of Shanghai
2021
Chinese Academy of Sciences
2021
Shanxi Medical University
2021
Merck (Germany)
2018
Lianyungang Oriental Hospital
2011
Zhenyu Gu, Masatoshi Nomura, Brenda B. Simpson, Hong Lei, Alie Feijen, Janny van den Eijnden-van Raaij, Patricia K. Donahoe, and En Li Cardiovascular Research Center, Massachusetts General Hospital East, Department of Medicine, Harvard Medical School, Charlestown, 02129, USA; Pediatric Surgical Laboratory, Hospital, Surgery, Boston, 02114, Hubrecht Netherlands Institute for Developmental Biology, Utrecht, The
Abstract The mechanism of local inflammation and systemic injury in chronic periodontitis is complicated, which exosomes play an important role. In our study, we found that T helper cell 17 (Th17)/regulatory (Treg) balance destabilized the peripheral blood patients with periodontitis, upregulated Th17 or downregulated Treg, respectively. Porphyromonas gingivalis lipopolysaccharide (LPS) was used to simulate inflammatory microenvironment periodontitis. were extracted from periodontal ligament...
We have shown that bone marrow (BM)-derived mesenchymal stem cells (BM-MSCs) from SLE patients exhibit senescent behavior and are involved in the pathogenesis of SLE. The aim this study was to investigate effects rapamycin (RAPA) on senescences immunoregulatory ability MSCs MRL/lpr mice underlying mechanisms. Cell morphology, senescence associated β-galactosidase (SA-β-gal) staining, F-actin staining were used detect cells. BM-MSCs purified CD4+ T co-cultured indirectly. Flow cytometry...
Abstract Dental pulp stem cells (DPSCs) are a type of mesenchymal (MSCs) characterised by self‐renewal and multi‐lineage differentiation, including chondrocytes, adipocytes, neural osteoblasts, which make it an attractive choice for tissue engineering purposes. Tumour necrosis factor α (TNF‐α) had the positive effect on mineralisation bone marrow MSCs stromal derived from human adipose tissue. However, TNF‐α DPSCs is unclear. We found that activated NF‐κB pathway during osteogenic...
Insulin‐like growth factor 1 ( IGF ‐1) is a multifunctional peptide that can enhance osteogenic differentiation of bone marrow mesenchymal stem cells BMMSC s). However, it remains unclear whether ‐1 promote human dental pulp DPSC In our study, s were isolated from the impacted third molars, and treated with ‐1. Osteogenic abilities investigated. We found activated m TOR signaling pathway during s. also increased expression runt‐related transcription 2 RUNX 2), osteocalcin OCN ), osterix OSX...
The prevalence of psychological problems is frequent in systemic lupus erythematosus (SLE) patients and appears to be increasing. current study investigated the relationship among disease parameters, quality life, status Chinese with SLE. A self-report survey design was administered 170 SLE 210 healthy individuals using Self-Rating Anxiety Scale, Depression Short Form 36 health (SF-36). Our results showed that 20.3% had anxiety, 32.9% depression, which were significantly higher than control...
The senescence of mesenchymal stem cells (MSCs) plays a crucial role in the development and progression systemic lupus erythematosus (SLE). Exosomes, small spherical bilayer proteolipid vesicles, contribute to communication between various their microenvironment by transferring information via cargo, including proteins, lipids, RNAs. While exosomal miRNAs participate biological activities, correlations circulating exosomes with senescent signs BM-MSCs remain unclear. In our study, we aimed...
Our and other groups have found that bone marrow-derived mesenchymal stem cells (BM-MSCs) from systemic lupus erythematosus (SLE) patients exhibited senescent behavior are involved in the pathogenesis of SLE. Numerous studies shown activation p53/p21 pathway inhibits proliferation BM-MSCs. The aim this study was to determine whether is regulating aging BM-MSCs SLE underlying mechanisms. We further confirmed showed characteristics senescence. expressions p53 p21 were significantly increased,...
As an important outcome measure among rheumatoid arthritis (RA) patients, functional disability may contribute to unemployment, loss of work productivity, and impaired quality life. However, little is known about the risk factors in Chinese RA patients. This study aimed (1) examine prevalence patients; (2) explore associated with health assessment questionnaire-disability index (HAQ-DI).A total 101 patients this cross-sectional underwent standardized laboratory examinations responded...
Poor sleep quality is common in rheumatoid arthritis (RA) patients and may lead to disease aggravation decreased health-related of life (HRQoL). The increasing prevalence poor RA associated with adverse demographic, clinical, psychological characteristics. However, there are currently no known reported studies related the effects on HRQoL from China. This cross-sectional study aims evaluate contributors Chinese patients.A self-report survey was administered 131 104 healthy individuals using...
To investigate the correlation among semi-quantitative scoring of blood flow by superb microvascular imaging (SMI), hypersensitive C-reactive protein (hs-CRP), erythrocyte sedimentation rate (ESR), and serum uric acid (SUA) levels in different gout duration. 103 patients (total 157 affected joints) with clinically confirmed acute attack from January 2021 to May 2022 were performed laboratory tests (hs-CRP, ESR, SUA), routine joint ultrasound scanning, along SMI, correlations between which...
Nonadherence in rheumatoid arthritis (RA) patients using disease-modifying antirheumatic drugs (DMARDs) may lead to joint damage and function loss. The aim of this cross-sectional study was explore Chinese RA patients' adherence rates investigate potential risk factors for nonadherence.A total 122 were recruited from the Affiliated Hospital Nantong University January 2014 April 2015. Patients asked complete a set standardized self-report questionnaires (Compliance Questionnaire on...