Polycystic ovary syndrome (PCOS) is a primary endocrine disorder affecting premenopausal women involving metabolic dysregulation. We aimed to screen serum biomarkers in PCOS patients using untargeted lipidomics and ensemble machine learning. Serum from non-PCOS subjects were collected for analysis. Through analyzing the classification of differential lipid metabolites association between clinical indexes, learning, data preprocessing, statistical test pre-screening, learning method secondary...

Genistein is a soy isoflavone that exists in the form of an aglycone. It primary active component and has number biological activities (anti-inflammatory anti-oxidative). However, specific effect genistein on human bone marrow mesenchymal stem cells (BMSCs) remains unclear. In present study, mechanism underlying suppression BMSC adipogenic differentiation enhancement osteogenic potential was investigated using MTT assay. observed significantly increased cell proliferation time-...

Flowering is a crucial process for plants that under complex genetic control. AP1 acts as an organizer and switch the transition from vegetative to reproductive growth. In our previous study, we found overexpression of BpAP1 significantly promoted formation male inflorescence in birch (Betula platyphlla × B. pendula). this aimed at investigating molecular regulatory mechanism during birch. We affected expression many flowering-related genes, had significant effect on B class MADS-box genes....

Background: Rheumatoid arthritis (RA) is a chronic inflammatory disease that causes significant physical and psychological damage. Although researchers have gained better understanding of the mechanisms RA, there are still difficulties in diagnosing treating RA. We applied data mining approach based on machine learning algorithms to explore new RA biomarkers local immune cell status. Methods: extracted six synovial microarray datasets from GEO database used bioinformatics obtain...

Combining acoustic signals and medical records to improve pathological voice classificationshih-hau fang 1 chi-te wang, 1,2,3 ji-ying chen, 1,3 yu tsao 4 feng-chuan lin 2,

The CUP-SHAPED COTYLEDON 2 (CUC2) gene, which is negatively regulated by microRNA164 (miR164), has been specifically linked to the regulation of leaf margin serration and maintenance phyllotaxy in model plants. However, few studies have investigated these effects woody In this study, we integrated genomic, transcriptomic, physiology approaches explore function BpCUC2 gene Betula pendula growth development. Our results showed that plants overexpressing BpCUC2, targeted BpmiR164, exhibit...

Abstract Background The proper timing of reimplantation is importation to treatment success in the two-stage exchange revision. 2018 International Consensus Meeting suggested that a variation trend toward normalization serum markers was useful for determining reimplantation. However, opposite results were found by previous studies, and reported fail predict infection control. We investigated whether value changes percent four common (erythrocyte sedimentation rate (ESR), C-reactive protein...

Artificial intelligence (AI) has promising applications in arthroplasty. In response to the knowledge explosion resulting from rapid growth of publications, we applied bibliometric analysis explore research profile and topical trends this field.The articles reviews related AI arthroplasty were retrieved 2000 2021. The Java-based Citespace, VOSviewer, R software-based Bibiometrix, an online platform systematically evaluated publications by countries, institutions, authors, journals,...

We participate in the FEMH 2018 Challenge of a bigdata subproject IEEE. The goal this is pathological voice detection, and classify different diseases, including phono trauma, neoplasm vocal paralysis. Final, challenge uses sensitivity, specificity UAR as result. database recorded with 50 normal samples 150 common disorders tertiary teaching hospital (Far Eastern Memorial Hospital, FEMH). paper proposes Deep Neural Networks based (DNN-based) approach challenge. Data preprocessing used...

The relevance between the presence of a sinus tract and failure risk after debridement, antibiotics implant retention (DAIR) for periprosthetic joint infection (PJI) hip or knee arthroplasty is still unclear. This study aimed to compare success rate DAIR patients with without explore possible factors in tract.Consecutive cases PJI January 2009 June 2019 minimum 1-year follow-up two tertiary centers were included. Patients classified into group non-sinus according tract. compared using...

Aims It can be extremely challenging to determine whether perform reimplantation in patients who have contradictory serum inflammatory markers and frozen section results. We investigated with a positive at were higher risk of reinfection despite normal ESR CRP. Methods retrospectively reviewed 163 consecutive periprosthetic joint infections (PJIs) had CRP results pre-reimplantation our hospital from 2014 2018. Of these patients, 26 sections reimplantation. The minimum follow-up time was two...

Abstract Background Inflammatory diseases are chronic autoimmune systemic diseases, which may increase the risk of prosthetic joint infection (PJI) after total arthroplasty (TJA). However, to our best knowledge, few studies have studied association between inflammatory and subsequent failure two-stage exchange reimplantation. The aims this study were identify differences in (1) serum markers, synovial indicators pathology results (2) treatment outcomes following patients with or without...

Abstract Objective To assess the clinical effect of staged joint replacement for treatment septic arthritic knee and therapeutic differences between antibiotic cement beads tibial plateau spacer. Methods Twenty-three patients (24 joints) treated with a arthritis were retrospectively reviewed March 2014 April 2018. At first stage, thorough debridement irrigation self-made or spacer performed. After that, systemic was followed; when infection surely eliminated, second-stage TKA Knee mobility...

Background Musculoskeletal (MSK) disorders, affecting billions of people worldwide, pose significant challenges to the healthcare system and require effective management models. The rapid development digital technologies (DHTs) has revolutionized industry. DHT-based interventions have shown promising clinical benefits in managing MSK alleviating pain, improving functional impairment. There is, however, no bibliometric analysis overall trends on this topic. Methods We extracted all relevant...

Spinal cord injury dramatically blocks information exchange between the central nervous system and peripheral system. The resulting fate of synapses in motor cortex has not been well studied. To explore synaptic reorganization after spinal injury, we established mouse models T12 hemi-section then monitored postsynaptic dendritic spines presynaptic axonal boutons pyramidal neurons hindlimb area vivo. Our results showed that led to remodeling bilaterally main regions changed over time. It made...

Background: Rheumatoid arthritis is a long-term systemic disease that primarily affects multiple synovial joints throughout the body. Some patients with severe joint effusion even require repeated arthrocentesis or arthroscopic debridement to relieve symptoms, which causes them much suffering mentally and physically. This text-mining study was designed find potential drugs target key genes in this disease.Methods: Firstly, we performed text mining by two keywords ("rheumatoid synovitis"...

Objective To investigate the accuracy of robotic-assisted UKA and its safety short term functional outcomes. Methods The clinical data 20 patients who received in Shanghai 6th People's Hospital Chinese PLA General from September 2016 to December were retrospectively reviewed, with 10 each hospital. All had a preoperative diagnosis osteoarthritis. Five simultaneous bilateral UKA. Of all patients, there 3 male 17 female an average age 65 years old (range 51 79 old) BMI (26.9±3.4) kg/m2....

Abstract Background The 2018 International Consensus Meeting suggested that a variation trend toward normalization in serum markers was useful for determining the proper timing of reimplantation. However, opposite results were found by previous studies, and reported to fail predict infection control. We investigated whether value changes percent four common (erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), interleukin-6 (IL-6) fibrinogen) can persistent infection? Methods A...