A5012271683- Orthopedic Infections and Treatments
- Orthopaedic implants and arthroplasty
- Total Knee Arthroplasty Outcomes
- Hip disorders and treatments
- Bone and Joint Diseases
- Spondyloarthritis Studies and Treatments
- Osteoarthritis Treatment and Mechanisms
- Streptococcal Infections and Treatments
- Rheumatoid Arthritis Research and Therapies
- Musculoskeletal synovial abnormalities and treatments
- Bone fractures and treatments
- Bacteriophages and microbial interactions
- Traditional Chinese Medicine Studies
- Botulinum Toxin and Related Neurological Disorders
- Silk-based biomaterials and applications
- MicroRNA in disease regulation
- Bone Metabolism and Diseases
- Infective Endocarditis Diagnosis and Management
- TGF-β signaling in diseases
- Lung Cancer Diagnosis and Treatment
- Healthcare and Venom Research
- Knee injuries and reconstruction techniques
- Hip and Femur Fractures
- Surgical Sutures and Adhesives
- Metallurgy and Material Science
Chinese PLA General Hospital
2012-2025
Second Hospital of Anhui Medical University
2025
Anhui Medical University
2025
University of Illinois Chicago
2024
Illinois College
2024
Chinese People's Liberation Army
2018-2023
PLA Academy of Military Science
2020-2021
People's Liberation Army No. 150 Hospital
2012-2020
Thomas Jefferson University
2019-2020
Rothman Orthopaedics
2019-2020
Antibiotic resistance is one of the main global threats to human health, and just development new antimicrobial medications not enough solve crisis. Phage therapy (PT), a safe effective treatment method, has reignited interest researchers due its efficacy in clinical drug-resistant bacterial infections. There is, however, no bibliometric analysis overall trends on this topic. Therefore, study aims provide an overview current state research area. We extracted all relevant publications from...
The success of debridement, antibiotics, and implant retention (DAIR) in early periprosthetic joint infection (PJI) largely depends on the presence a mature biofilm. At what time point DAIR should be disrecommended is unknown. This multicenter study evaluated outcome relation to after index arthroplasty.We retrospectively PJIs occurring within 90 days surgery treated with DAIR. Patients bacteremia, arthroscopic debridements, follow-up <1 year were excluded. Treatment failure was defined as...
Objective Robot‐assisted surgery has been promoted worldwide in recent years. The development of a domestic orthopaedic robot and its clinical application are therefore great significance. This study aimed to compare the early radiographic outcomes robot‐assisted total knee arthroplasty (RA‐TKA) with conventional manual (CM‐TKA). Methods A 77 patients who underwent primary single‐sided TKA from June December 2020 were prospectively enrolled; resulting inclusion 72 patients. randomly divided...
Diabetes mellitus is a common metabolic disorder, and diabetic erectile dysfunction (DMED) one of its complications. The differentiation the types (ED) fundamental to treatment, yet there lack simple efficacious tools for this purpose in clinical practice. In study, we endeavor predict ED using commonly available data from patients, aiming develop assess risk prediction model organic individuals with type 2 diabetes. study was retrospective analysis. Data were obtained hospital's internal...
This study reports the mid-term outcomes of primary total hip arthroplasty (THA) and investigates effect bony ankylosis on postoperative function in patients with ankylosing spondylitis (AS). We identified 544 THAs performed 319 consecutive AS (median age, 33 years) from 2012 to 2017. Survivorship implants, complications, patient satisfaction were investigated. Functional assessed by measurement flexion–extension range motion (ROM), Harris score (HHS), Western Ontario McMaster Universities...
Osteoarthritis (OA) is characterised by articular cartilage degradation. MicroRNAs (miRNAs) have been identified in the development of OA. The purpose our study was to explore functional role and underlying mechanism miR-138-5p interleukin-1 beta (IL-1β)-induced extracellular matrix (ECM) degradation OA cartilage.Human obtained from patients with without OA, chondrocytes were isolated stimulated IL-1β. expression levels both determined. After transfection mimics, allele-specific...
Background: The diagnosis of periprosthetic joint infection (PJI) in the early postoperative period remains a challenge. Although studies have established that serum C-reactive protein (CRP) and synovial markers may be useful, recent suggested current thresholds used lack sensitivity. purpose this study was to examine role CRP, erythrocyte sedimentation rate (ESR), fluid white blood-cell (WBC) count, polymorphonuclear neutrophil (PMN) percentage acute PJI identify optimal threshold. Methods:...
The aim of this study was to investigate the effects insulin-like growth factor-I, transforming factor-beta (TGF-beta), and interluekin-1 alpha (IL-1 alpha) on deposition degradation a cartilage-like matrix in high-density pellet cultures adult bovine chondrocytes. Proteoglycan determined by toluidine blue staining colorimetric assay. Type II collagen immunohistochemical its unwinding situ recently developed immunoassay. Bovine nasal chondrocytes cultured as pellets deposited well-organized...
The diagnosis of persistent infection before reimplantation in two-stage exchange arthroplasty for periprosthetic joint (PJI) remains challenging. Currently, several studies suggested coagulation-related markers, such as D-dimer and fibrinogen, may be promising diagnose PJI. purpose the study was to investigate predictive values plasma fibrinogen assessment hip arthroplasty. We retrospectively reviewed 129 hips that treated with PJI from 2012 2016 our institution. based on a modified...
The treatment strategy for evolutive septic arthritis (SA) with coexistent degenerative joint disease is not well established. purposes of this study were to 1) investigate outcome and potential risk factors failure in patients SA following two-stage procedure, including insertion an antibiotic-loaded spacer at the first stage subsequent implantation a new prosthesis; 2) determine performance serum erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), Interleukin-6 (IL-6)...
The prevalence and role of malnutrition in periprosthetic joint infection (PJI) remain unclear. This study aimed to use measurable nutritional screening tools assess the PJI patients during two-stage exchange arthroplasty explore association between treatment failure. Our retrospectively included 183 cases who underwent 1st stage had available parameters, which 167 proceeded with 2nd reimplantation. recently proposed Musculoskeletal Infection Society (MSIS) Outcome Reporting Tool was used...