Two-stage revision is the standard procedure for periprosthetic knee infection. But when to perform second-stage still under debate. We attempt search reliable indicators, risk factors, and proper timing revision. reviewed followed 81 infected total arthroplasty patients who underwent two-stage from January 2010 2014. Our cohort included 56 males 25 females, all were confirmed as PJI with same phenotypic cultures. The average age was 64.8 ± 8.21 (range 36–78) months. mean follow-up time 46.5...

To resolve the problems of bacterial infections and low efficiency osteogenesis implanted titanium alloys in clinical dental bone therapy, we developed a bifunctional alloy (Ti) with nano-hydroxyapatite (HA) coating (HBD + BMP/HA-Ti), which enables sustained release natural antimicrobial peptide human β-defensin 3 (HBD-3) morphogenetic protein-2 (BMP-2). Due to poriferous nano-sized structure HA 20-30 μm thickness, HBD BMP/HA-Ti material had high encapsulation (>74%) exhibited synchronized...

Fungal prosthetic joint infections (PJI) and reports of their clinical investigation are rare. In addition, there has been little evidence regarding the outcome two-stage exchange protocol for treatment fungal PJI. order to investigate risk factors clinical, microbiological pathological features PJIs, as well effects on outcome, present study analyzed eight retrospective PJI cases, involving four cases affecting hips knees, between May 2000 March 2012. all a cemented spacer saturated with...

BACKGROUND Long non-coding RNAs (lncRNAs) have been confirmed to play an important role in the development and progression of diseases. Ankylosing spondylitis (AS) is a chronic inflammatory systemic disease it hard be found early time. The purpose this study was investigate lncRNA-AK001085 diagnosis AS. MATERIAL AND METHODS expression detected by quantitative real-time polymerase chain reaction (qRT-PCR) analysis. relationship between its clinicopathologic characteristics also analyzed....

Objectives We aimed to show the utility of high hip center technique used in patients with Crowe II–III developmental dysplasia at midterm follow‐up and evaluated clinical radiographic results between different heights center. Methods From December 2003 November 2013, we retrospectively 69 (85 hips) who underwent a cementless total arthroplasty. The were divided into two groups according height center, respectively group A (≥ 22 mm < 28 mm) B (≥28 mm). survivorship outcomes results,...

With the development of radiology and three-dimensional (3D) printing technology, custom-made 3D-printed titanium augments have been more widely used. However, radiological clinical outcomes lack reports. To better understand effect using significance accurate placement, aim this study was to assess when validate idea that surgical simulation should be done before designing augments.A retrospective review conducted on 31 simulations revision total hip arthroplasties augments. The safe zone,...

BACKGROUND The aim of this study was to investigate the success rate fungal peri-prosthetic joint infection treated by 2-stage revision and related factors treatment failure offer a better protocol. MATERIAL AND METHODS We reviewed 18 joints (13 knees 5 hips) 17 patients (10 women 7 men) diagnosed with from January 2000 June 2015 at our institute. mean follow-up 65.1 months (range, 25-129 months). All were complete debridement, implantation antifungal-loaded cement spacers, least 6 weeks...

The screw and cement technique is a convenient method used to rebuild medial tibial plateau defects in primary total knee arthroplasty (TKA). objective of this study was perform finite element assessment determine the effect different numbers screws on stability TKA whether differences exist between two insertion angles.Six models with filled one model only were generated. Contact stresses surface cancellous bone areas calculated.Compared cement-only technique, stress border decreased by 10%...

To explore the possibility of obtaining more accurate information from routine blood tests for diagnosis periprosthetic joint infection (PJI).This is a retrospective study. Between 2017 and 2018, total 246 patients who underwent hip or knee revision surgery were included in this There 146 females 100 males, mean age was 62.1 ± 12.75 years. Laboratory parameters erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), D-dimer, plasma fibrinogen, serum white cell (WBC), calculable ratio...

The purpose of this study was to establish the finite element analysis (FEA) model acetabular bone defect reconstructed by 3D printed Ti6Al4V augment and TM further analyze stress distribution clinical safety augments, screws, bones.The FEA established CT data a patient with Paprosky IIIA defect. von Mises stresses bones were analyzed single-legged stance loading applied in 3 increments (500 N, 2000 3000 N).The peak under maximal cortical less than yield strength corresponding component....

Objective To explore the leg length balance in total hip arthroplasty (THA) with shortening subtrochanteric osteotomy (SSTO) or not for unilateral Crowe type IV developmental dysplasia of (DDH) through evaluation postoperative full‐length anteroposterior radiographs. Methods The radiographs 60 patients DDH from July 2012 to May 2019 were retrospectively reviewed. All underwent THA using Pinnacle Acetabular Cup system, a ceramic liner and femoral head, S‐ROM stem proximal sleeve cone....

The relationship of C-reactive protein (CRP)/interleukin-6 (IL-6) concentrations between serum and synovial fluid whether CRP/IL-6 testing in addition to would result a benefit the diagnosis periprosthetic joint infection (PJI) deserves be investigated.From June 2016 July 2019, 139 patients were included study. Synovial CRP IL-6 tested by ELISA. obtained from medical records. definition PJI was based on modified Musculoskeletal Infection Society (MSIS) criteria. value each index...

To introduce the surgical technique of reconstruction Paprosky type III acetabular defects by 3D printed porous augments.First, CT scans pelvis were obtained to establish model augment. Then, a nylon was simulate operation with surgeons. At this time, augment designed and modified according surgeon's suggestions printing principles. Eighteen patients receiving reconstructive surgery augments included in current study. Their data, including general information, intra-operative findings,...

Objective Both porous metal cones and metaphyseal sleeves are excellent implants for reconstructing severe bone defects in the knee joint, but they both exhibit design limitations. The cone, especially, has significant room improvement its shape design. existing often feature a conical external surface with relatively small taper, potentially compromising rotational axial stability. To improve stability cones, we developed 3D‐printed stepped cone. This study aimed to assess short‐term...

Abstract Background Managing periprosthetic joint infections are variable in practices. Debridement, antibiotics, and implant retention (DAIR) is one of the favorable interventions. Given that success rate two-stage revision total knee arthroplasty (rTKA) might be overestimated. The purpose this study to compare between DAIR standard rTKA with a comparable intervention time. Methods We retrospectively reviewed consecutive infection cases which underwent or (all procedures were performed by...

The purpose of this study was to establish the finite element analysis (FEA) model acetabular bone defect in Crowe type II or III developmental dysplasia hip (DDH), which could evaluate stability cup with different types defects, diameters femoral ceramic heads, and use screws analyze stress distribution screws.The FEA based on CT scan a female patient without any defect. total arthroplasty for DDH made by increasing superolateral area cup. Point A located most medial part 52 mm PINNACLE...

Abstract Background The proper timing of reimplantation is importation to treatment success in the two-stage exchange revision. 2018 International Consensus Meeting suggested that a variation trend toward normalization serum markers was useful for determining reimplantation. However, opposite results were found by previous studies, and reported fail predict infection control. We investigated whether value changes percent four common (erythrocyte sedimentation rate (ESR), C-reactive protein...

Objective The aim of the present paper was to evaluate results one‐stage total hip arthroplasty (THA) for patients with bilateral Crowe type IV developmental dysplasia (DDH). Methods Data 58 (116 hips) DDH who had THA performed by same surgeon during period April 2008 February 2019 were retrospectively reviewed. mean age 37.3 years; 5 men and 53 women. All underwent through posterolateral approach using Pinnacle acetabular cup, a ceramic‐on‐ceramic bearing, modular S‐ROM stem....

Objective This study examined the trends in demographics, distribution of microorganisms, and antibiotic resistance patients with periprosthetic joint infection (PJI). Methods We conducted a retrospective 231 consecutive diagnosed PJI our hospital from January 2006 to December 2015 (93 138 2006–2010 2011–2015, respectively). The linear-by-linear chi-squared test was used assess resistance. Results Gram-positive cocci accounted for 63.9% all pathogens, coagulase-negative Staphylococcus (CoNS)...