A5053759817- Orthopaedic implants and arthroplasty
- Orthopedic Infections and Treatments
- Hip disorders and treatments
- Total Knee Arthroplasty Outcomes
- Musculoskeletal pain and rehabilitation
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Corneal Surgery and Treatments
- Pain Management and Opioid Use
- Bone and Joint Diseases
- Cancer-related molecular mechanisms research
- Cancer Genomics and Diagnostics
- Cancer Research and Treatments
- Corneal surgery and disorders
- Cancer, Hypoxia, and Metabolism
- Eicosanoids and Hypertension Pharmacology
- Salivary Gland Disorders and Functions
- Acute Kidney Injury Research
- Lung Cancer Treatments and Mutations
- Pharmacological Receptor Mechanisms and Effects
- Liver Disease Diagnosis and Treatment
- Inflammasome and immune disorders
- Optical Imaging and Spectroscopy Techniques
- Liver physiology and pathology
- Muscle and Compartmental Disorders
Shanghai Skin Disease Hospital
2025
Tongji University
2025
China Pharmaceutical University
2025
Peking University
2021-2025
Peking University Cancer Hospital
2021-2025
Chinese PLA General Hospital
2021-2024
Dalian Polytechnic University
2024
PLA Academy of Military Science
2022-2023
Fujian Medical University
2023
University of Virginia
2022
<sec><b>Objective</b>Immunotherapeutic outcomes and clinical characteristics of claudin 18 isoform 2 positive (CLDN18.2-positive) gastric cancer (GC) vary in different studies, making it difficult to optimize anti-CLDN18.2 therapy. We conducted a retrospective analysis explore the association CLDN18.2 expression with clinicopathological immunotherapeutic GC.</sec><sec><b>Methods</b>A total 536 advanced GC patients from 2019 2021 CT041-CG4006 CT041-ST-01 trials were included analysis. on ≥40%...
Chimeric antigen receptor T cell (CAR T) therapy has been successfully used to treat hematological malignancies. Nonetheless, its application solid tumors remains challenging. Our previous analysis of the ongoing clinical trial (NCT03874897) demonstrated promising results in patients with advanced CLDN18.2-positive gastric cancer who received CT041 CAR treatment. Here, we collected peripheral blood and ascites from five 3 7 days (d) after infusion. Patients a high proportion naïve-like cells...
Recent studies have shown that microorganisms can be present in organs or blood traditionally considered sterile, both healthy and diseased individuals. In this study, we investigated the presence of 'sterile' (brain, heart, kidney, liver, lung, spleen) commercially available experimental mice using culturomics metagenomics. To avoid potential environmental contamination, strict disinfection assays were performed. Among 104 C57BL/6J, BALB/c, ICR strains purchased from three major animal...
The objective of this study was to evaluate the accuracy acetabular cup positioning in obese patients when using robotic-assisted technology during total hip arthroplasty (THA).Data were retrospectively collected from who underwent primary (THA) with a body mass index (BMI) ≥ 28 kg/m2 and 1 year follow-up between January 2018 December 2019. Their demographics, diagnosis, positioning, American Society Anesthesiologists (ASA) score, Harris Hip Score (HHS), Forgotten Joint (FJS) at final...
Objective: Many previous studies have reported that pain symptoms can lead to significant brain function and anatomical changes, whereas the intrinsic activity changes in acute eye (EP) patients remain unknown. Using amplitude of low-frequency fluctuation (ALFF) method, this study aimed evaluate spontaneous alterations their relationships with clinical features EP patients. Participants methods: A total 20 (15 males 5 females) healthy controls (HCs; 15 closely matched age, sex, education...
Advocates of robot-assisted technique argue that robots could improve leg length restoration in total hip replacement. However, there were few studies to compare the posterior approach (RPA) with conventional (PA) THA and direct anterior (DAA) LLD. This study aimed determine whether techniques significantly reduce LLD compared manual DAA PA.We retrospectively reviewed cohort consecutive ONFH patients who underwent posterior, from January 2018 December 2020 one institution. One experienced...
Pathogens are capable of hijacking immune defense mechanisms, thereby creating a tolerogenic environment for hypermutated malignant cells that arise within the site infection. Immune checkpoint-oriented immunotherapies have shown considerable promise. Equally important, epigenetic reprogramming an immune-evasive phenotype activates system in synergistic manner can improve immunotherapy outcomes. These advances led to combinations epigenetic- and immune-based therapeutics. We previously...
Lung adenocarcinoma (LAD) is a human malignancy successfully treated with the tyrosine kinase inhibitor (TKI) gefitinib; however, enrichment of therapy resistant cancer stem cells (CSCs) in such patients assumed to be source treatment failure. Evaluation LAD cell populations TKI gefitinib identified unique aspects subpopulation tumor exhibiting stem-like properties and mitochondria-specific metabolic features along their reliance on sirtuin 1 (SIRT1) for survival advantage. This addiction...
Alkali burn is one of the main causes corneal injury. The inflammation and neovascularization caused by alkali burns aggravate damage, resulting in loss vision. aim present study was to evaluate efficacy xanthatin treatment burn‑induced neovascularization. A CCK‑8 assay used detect effects different concentrations on proliferation human umbilical vein endothelial cells (HUVECs). migration HUVECs ability lumen formation were examined using a scratch test assay, respectively. total 60...
Abstract Hepatic progenitor cells (HPCs) hold tremendous potential for liver regeneration, but their well-known limitation of proliferation hampers broader use. There is evidence that laminin required the HPCs, isoform plays dominant role and key intracellular downstream targets mediate regulation HPC have yet to be determined. Here we showed p53 expression increased gradually reached maximal levels around 8 days when α4, α5, β2, β1, γ1 subunit also a maximum during activation expansion....
The elucidation of the interaction mechanism between phospholipids and milk proteins within emulsions is pivotal for comprehending properties infant formula fat globules. In this study, multispectral methods molecular docking were employed to explore relationship phosphatidylcholine (PC) whey protein isolate (WPI). Observations indicate that binding constant, alongside thermodynamic parameters, diminishes as temperature ascends, hinting at a predominantly static quenching mechanism....
Hypoxia-inducible factors (HIFs) are key regulators in oxygen homeostasis. Their stabilization and activity regulated by prolyl hydroxylase domain (PHD)-1, -2, -3 factor inhibiting HIF (FIH). This study investigated the relation between these sensors clinical behaviors prognosis of hepatocellular carcinoma (HCC). Tissue microarray RT-PCR analysis tumor tissues adjacent non-tumor liver revealed that mRNA protein levels both PHD3 FIH were lower within tumors. The expression was associated with...
Neurotrophic tropomyosin receptor kinase (NTRK) gene fusions are rare oncogenic drivers and targets of TRK inhibitors in solid tumors. Little is known about NTRK fusion Chinese patients with pan-cancer. Our study investigated the prevalence genomic features NTRK1/2/3 67 883 pan-cancer using next-generation sequencing (NGS) data circulating tumor DNA (ctDNA) NGS to guide inhibitor treatment resistance monitoring. The (tissue NGS) population was 0.18%, 46 unique NTRK-fusion partner pairs,...
Background Robotic‐assisted technology may be useful in hip revision cases with acetabular defects. However, data on the use of robotic‐assisted for such complex diseases is lacking. Case Presentation This case study described adoption MAKO treatment total arthroplasty (THA) combined severe defect (Paprosky type IIIB). accurately achieved preoperative planning; component and augment were placed original position angle as planned. reaming was successful a single pass, preserving remaining...