A5101628988- Functional Brain Connectivity Studies
- Ocular Infections and Treatments
- Advanced Neuroimaging Techniques and Applications
- Glaucoma and retinal disorders
- Ocular Surface and Contact Lens
- Corneal Surgery and Treatments
- Ophthalmology and Visual Impairment Studies
- Corneal surgery and disorders
- Visual perception and processing mechanisms
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Stress Responses and Cortisol
- Neural and Behavioral Psychology Studies
- Trigeminal Neuralgia and Treatments
- Antifungal resistance and susceptibility
- Photoacoustic and Ultrasonic Imaging
- Retinal Diseases and Treatments
- Radiation Detection and Scintillator Technologies
- Genetics and Neurodevelopmental Disorders
- Traumatic Ocular and Foreign Body Injuries
- Optical Imaging and Spectroscopy Techniques
- Retinopathy of Prematurity Studies
- Ultrasound and Hyperthermia Applications
- Medical Imaging Techniques and Applications
- Receptor Mechanisms and Signaling
- Genomic variations and chromosomal abnormalities
Beijing University of Technology
2024-2025
New York University
2025
Chengdu Medical College
2025
Wenzhou Medical University
2022-2024
Nanchang University
2016-2024
Qingdao University
2008-2024
Affiliated Hospital of Qingdao University
2010-2024
Peking Union Medical College Hospital
2022-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2024
South China Normal University
2023-2024
Abstract Glucocorticoids (GCs) are the most prescribed anti-inflammatory and immunosuppressive drugs. However, their use is often limited by substantial side effects, such as GC-induced osteoporosis (GIO) with underlying mechanisms still not fully understood. In this study, we identify Tau a low-affinity binding receptor for GCs that plays crucial role in GIO. deficiency largely abolished bone loss induced high-dose dexamethasone, synthetic GC, both inflammatory arthritis GIO models....
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIn vivo evidence that UV-induced C .fwdarw. T mutations at dipyrimidine sites could result from the replicative bypass of cis-syn cyclobutane dimers or their deamination productsNan Jiang and John Stephen TaylorCite this: Biochemistry 1993, 32, 2, 472–481Publication Date (Print):January 19, 1993Publication History Published online1 May 2002Published inissue 19 January...
Purpose.: To determine the role of lectin-like oxidized low-density lipoprotein receptor 1 (LOX-1) in corneal epithelial cells exposed to fungus. Methods.: Thirteen corneas with fungal keratitis composed experimental group. Ten healthy donor were control Corneal epithelium was scraped and LOX-1 mRNA tested. Immunostaining used detect protein. Human (HCECs) treated 75% ethanol-killed Aspergillus fumigatus. detected, CXCL1, TNF-α, IL-6, dectin-1 levels detected or without neutralization LOX-1....
Previous studies have demonstrated that strabismus or amblyopia can result in markedly brain function and anatomical alterations. However, the differences spontaneous activities of with (SA) patients still remain unclear. This current study intended to use amplitude low-frequency fluctuation (ALFF) technique investigate intrinsic activity changes SA subjects.A total 16 (6 males 10 females) healthy controls (HCs; 6 similarly matched age, gender, education status were recruited examined...
To determine the role of autophagy in innate immune response to fungal keratitis (FK) caused by Aspergillus fumigatus infection.Corneal samples obtained from patients and mice with FK were visualized via transmission electron microscopy (TEM). Autophagy-related proteins LC3B-II, Beclin-1, LAMP-1, p62 A. fumigatus-infected corneas C57BL/6 tested Western blot. After treatment inhibitors 3-methyladenine (3-MA), chloroquine (CQ), or inducer rapamycin, autophagy-related detected Corneas...
The mutation spectra of cis-syn, trans-syn-I, (6−4), and Dewar pyrimidone photoproducts the TT site AATTAA TATTAT in (−) strand a heteroduplex M13 vector were obtained an excision photoreversal repair deficient Escherichia coli host under SOS conditions. Oligonucleotides containing site-specific annealed to complementary uracil-containing (+) that contained one or more unique pairs nucleotide mismatches used prime synthesis with DNA polymerase dNTPs. Following synthesis, reaction mixtures...
Indoleamine 2,3-dioxygenase (IDO), which is mainly expressed in activated dendritic cells, known as a regulator of immune responses. However, the role IDO responses against fungal corneal infection has not been investigated. To evaluate regulatory mechanisms inflammation, we resorted to human epithelial cells (HCECs), first barrier cornea pathogenic microorganisms. We found that was significantly up-regulated epithelium infected with Aspergillus fumigatus (A. fumigatus) and HCECs incubated...
To evaluate the differences in functional connectivity (FC) of primary visual cortex (V1) between youth comitant exotropia (CE) patients and health subjects using resting magnetic resonance imaging (fMRI) data.Totally, 32 CEs (25 males 7 females) healthy control (HCs) were enrolled study underwent MRI scanning. Two-sample t-test was used to examine FC maps CE HCs.The showed significantly less left brodmann area (BA17) lingual gyrus/cerebellum posterior lobe, right middle occipital gyrus,...
Abstract Objective Neuroimaging studies have shown that patients with pain‐related conditions altered neuronal activity and structural functions. The purpose of this study was to investigate whether classical trigeminal neuralgia ( CTN ) exhibit changes in corresponding via analysis regional homogeneity (ReHo). Methods A total 28 presenting sore eyes (12 men 16 women) were matched healthy controls women). All participants underwent functional magnetic resonance imaging fMRI ). This ReHo...
To prepare a nanobody specific to dectin 1 and verify its specificity anti-inflammatory effects on Aspergillus fumigatus keratitis.The was selected from high-quality shark-antibody library constructed with phage-display technology. The developed in the expression systems of Escherichia coli. Indirect ELISA used determine recombinant protein. potential be recognized expressed surfaces cells corneas detected by immunofluorescence, effect A. keratitis further verified. After infection...
To identify whether Aspergillus fumigatus (A. fumigatus) hyphae antigens induced the release of interleukin-8 (IL-8) in anti-fungal innate immunity cultured human corneal epithelial cells (HCECs) and determine involvement intracellular signalling pathways.HCECs were treated with A. different concentrations time. The cytoplasmic calcium HCECs assessed by fluorescence imaging. Western blot was used to detect expression Ca(2+)-dependent protein kinase C (PKC). IL-8 levels determined specific...
Objective: Many previous studies have reported that pain symptoms can lead to significant brain function and anatomical changes, whereas the intrinsic activity changes in acute eye (EP) patients remain unknown. Using amplitude of low-frequency fluctuation (ALFF) method, this study aimed evaluate spontaneous alterations their relationships with clinical features EP patients. Participants methods: A total 20 (15 males 5 females) healthy controls (HCs; 15 closely matched age, sex, education...
The aim of this study was to evaluate altered spontaneous brain activities in patients with unilateral acute open globe injury (OGI) using amplitude low-frequency fluctuation (ALFF) method and its relationship their clinical manifestations.A total 18 OGI (16 males two females) healthy controls (HCs, 16 closely matched age, sex, education were recruited study. ALFF used the activities. relationships between mean signal values different regions features evaluated by correlation analysis. Acute...
Background Neuroimaging studies revealed that trigeminal neuralgia was related to alternations in brain anatomical function and regional function. However, the functional characteristics of network organization whole is unknown. Purpose The aim present study analyze potential brain-activity changes their relationships with clinical features patients via voxel-wise degree centrality method. Material Methods This involved a total 28 (12 men, 16 women) healthy controls matched sex, age,...
Recent studies have reported structural and functional abnormalities in multiple brain regions of classical trigeminal neuralgia (CTN) patients. Differences spontaneous neuronal activity between CTN patients healthy subjects, however, remain unknown. The aim the present study was to investigate alterations by application amplitude low frequency fluctuation (ALFF), thus analyzing correlation durations pain intensity ALFF values A total 28 (male, n=12; female, n=16) controls (HCs; male,...
To explore the effects of lectin-like ox-LDL receptor (LOX-1) on innate immunity against Aspergillus fumigatus (A. ) in mice cornea.The mRNA levels LOX-1 were tested normal and A. infected corneas C57BL/6 BALB/c mice. The expression LOX-1, pro-inflammatory cytokines TNF-α, CXCL1 IL-6, anti-inflammatory IL-10, matrix metalloproteinase 9 (MMP9) with treatment neutralizing antibody or control IgG C57BL/6. Macrophages neutrophils extracted from susceptible mice, pretreated IgG, then stimulated...
This study investigated the changes in interhemispheric functional connectivity (FC) of whole brain open globe injury (OGI) patients, using voxel-mirrored homotopic (VMHC), and their relationships with clinical features. Totally, 16 male 2 female acute OGI patients 18 sex, age, education-matched healthy volunteers were enrolled study. All subjects scanned through magnetic resonance imaging (fMRI). Receiver operating characteristic (ROC) curves analyses had been used to identify VMHC these...
Many previous studies have demonstrated that the blindness patients has functional and anatomical abnormalities in visual other vision-related cortex. However, changes brain function late monocular (MB) at rest are largely unknown. In this study, we investigated underlying regional homogeneity (ReHo) of brain-activity with MB their relationship clinical features. A total 32 (25 male seven female) healthy controls (HCs) closely matched age, sex, education underwent resting-state MRI scans....
Alkali burn is one of the main causes corneal injury. The inflammation and neovascularization caused by alkali burns aggravate damage, resulting in loss vision. aim present study was to evaluate efficacy xanthatin treatment burn‑induced neovascularization. A CCK‑8 assay used detect effects different concentrations on proliferation human umbilical vein endothelial cells (HUVECs). migration HUVECs ability lumen formation were examined using a scratch test assay, respectively. total 60...
Previous neuroimaging studies have demonstrated that pain-related diseases are associated with brain function and anatomical abnormalities, whereas altered synchronous neural activity in acute eye pain (EP) patients has not been investigated. The purpose of this study was to explore whether or changes were measured the regional homogeneity (ReHo) method EP patients.A total 20 (15 males 5 females) healthy controls (HCs) consisting 15 age-, sex-, education-matched females, respectively,...