Abstract Background It is known that measuring the triglyceride glucose (TyG) index and TyG-related parameters [triglyceride glucose-body mass (TyG-BMI), glucose-waist circumference (TyG-WC), to height ratio (TyG-WHtR)] can predict diabetes; this study aimed compare predictive value of baseline TyG for onset diabetes at different future periods. Methods We conducted a longitudinal cohort involving 15,464 Japanese people who had undergone health physical examinations. The subject’s were...

Objective The Estimated Glucose Disposal Rate (eGDR) serves as a surrogate marker for insulin resistance, with numerous studies highlighting its significant prognostic value. This paper aims to analyze the impact of eGDR on cardiovascular and all-cause mortality across different glycemic metabolic statuses, including normal fasting glucose (NFG), prediabetes, diabetes. Methods study included 46,016 American adults who underwent health examinations part National Health Nutrition Examination...

Objective The metabolic score for insulin resistance (MetS-IR) is an emerging surrogate marker (IR). This study aimed to investigate the association and sex differences between MetS-IR prediabetes risk in a Chinese population. Methods cohort included 100,309 adults with normoglycemia at baseline had followed longitudinally 5 years, prediabetes, defined according 2018 American Diabetes Association (ADA) recommended diagnostic criteria, as outcome of interest. Multivariate Cox proportional...

The relationship between remnant-like particle cholesterol (RLP-C) and cardiovascular disease risk prognosis has been established, but its effect on the of ischemic heart failure (IHF) patients undergoing percutaneous coronary intervention (PCI) remains uncertain. In this study, 2036 with IHF who underwent PCI were included. Patients categorized into tertiles based their RLP-C levels. primary outcome was major adverse events (MACE). Kaplan-Meier survival analysis used to assess incidence...

Objective Prediabetes is a chronic condition characterized by elevated blood glucose levels that are not yet high enough to be classified as diabetes. It particularly prevalent among middle-aged and elderly populations. This study aims investigate the association between novel marker of insulin resistance-the estimated disposal rate (eGDR)-and reversion prediabetes normoglycaemia or progression diabetes in Chinese population. Methods prospective cohort utilized baseline data from 2011 China...

The blood urea nitrogen-to-albumin ratio (BAR) is considered a potential indicator for assessing the poor prognosis of heart failure (HF). However, its prognostic value Chinese patients with acute decompensated HF (ADHF) remains unclear. This study included ADHF who met criteria and were admitted to Jiangxi Provincial People's Hospital from 2019 2022. We first employed univariate multivariate Cox regression models determine role BAR in evaluating short-term patients. Subsequently, we used...

To compare the difference in white matter volume (WMV) and gray (GMV) between comitant strabismus (CS) patients health controls by voxel-based morphometry (VBM) relationship with behavioral performance. A total of 20 (10 males 10 females), healthy subjects females) matched age, sex status underwent magnetic resonance examination. The authors analyzed original 3D T1 brain images using VBM module. groups were compared control for GMW WMV entire brain. Correlation analysis was performed to...

To use the amplitude of low-frequency fluctuation (ALFF) technique to investigate local features spontaneous brain activity in optic neuritis (ON) and their relationship with behavioral performance.Twelve patients ON (four male, eight female) twelve age-, sex-, education status-matched healthy controls (HCs) underwent resting-state functional magnetic resonance imaging (rs-fMRI) scans. The ALFF was used assess activity. Correlation analysis explore between observed mean values different...

To investigate the underlying regional homogeneity (ReHo) of brain-activity abnormalities in patients with comitant strabismus (CS) and their relationship behavioral performance.Twenty CS (ten men ten women) 20 age-, sex-, education-matched healthy controls (HCs) underwent resting-state functional magnetic resonance imaging scans. The ReHo method was used to assess local features spontaneous brain activities. Patients were distinguished from HCs by receiver operating characteristic curve....

To evaluate the differences in functional connectivity (FC) of primary visual cortex (V1) between youth comitant exotropia (CE) patients and health subjects using resting magnetic resonance imaging (fMRI) data.Totally, 32 CEs (25 males 7 females) healthy control (HCs) were enrolled study underwent MRI scanning. Two-sample t-test was used to examine FC maps CE HCs.The showed significantly less left brodmann area (BA17) lingual gyrus/cerebellum posterior lobe, right middle occipital gyrus,...

Actinin alpha 4 (ACTN4) is expressed in the kidney podocytes. ACTN4 gene methylation patients with diabetic nephropathy (DN) remains high. Underlying mechanism of epigallocatechin-3-gallate (EGCG) inducing demethylation, and its inhibitory effect on DN renal fibrosis unclear.Human podocyte cell line, HPC, was treated high glucose to establish model DN. The levels cytokines, vascular endothelial growth factor (VEGF) interleukin (IL)-8, markers, smooth muscle actin (α-SMA) fibronectin (FN),...

The aim of this study was to investigate the fractional anisotropy (FA) and mean diffusivity (MD) using a diffusion tensor imaging technique whole-brain voxel-based analysis in patients with comitant strabismus.A total 19 (nine males ten females) strabismus age-, sex-, education-matched healthy controls (HCs) underwent magnetic resonance examination. Imaging data were analyzed two-sample t-tests identify group differences FA MD values. Patients distinguishable from HCs by receiver operating...

To investigate the underlying regional homogeneity (ReHo) brain activity changes in patients with unilateral acute open-globe injury (OGI) and their relationship clinical features.In total, 18 OGI (16 males two females) healthy controls (HCs; 16 closely matched age, sex, education status participated study. Each subject underwent a resting-state functional magnetic resonance imaging scan. The ReHo method was used to assess local features of spontaneous activity. Receiver-operating...

Thyroid-associated ophthalmopathy (TAO) is a vision threatening autoimmune and inflammatory orbital disease, has been reported to be associated with wide range of structural functional abnormalities bilateral hemispheres. However, whether the interhemisphere connectivity (FC) TAO patients altered still remain unclear. A new technique called voxel-mirrored homotopic (VMHC) combined support vector machine (SVM) method was used in present study explore interhemispheric alterations TAO.A total...

Objectives Previous studies demonstrated that thyroid-associated ophthalmopathy (TAO) patients were accompanied by cognitive decline. However, The exact neural mechanisms of decline in TAO remain unclear. Our study aimed to investigate the spontaneous brain activity alterations using amplitude low-frequency fluctuation (ALFF) method and their relationships with clinical features patients. Materials methods In total, twenty-one (14 men 7 women) 21 healthy control (HC) subjects enrolled this...

Background: Previous imaging studies have demonstrated that diabetic retinopathy (DR) is linked to structural and functional abnormalities in the brain. However, extent which DR patients exhibit abnormal neurovascular coupling remains largely unknown. Methods: Thirty-one with 31 sex- age-matched healthy controls underwent resting-state magnetic resonance (rs-fMRI) calculate connectivity strength (FCS) arterial spin-labeling (ASL) cerebral blood flow (CBF). The study compared CBF-FCS across...

Linkage disequilibrium (LD) is a key metric that characterizes populations in flux. To reach genomic scale LD illustration, which has substantial computational cost of O(nm2), we introduce framework with two novel algorithms for estimation: X-LD, time complexity O(n2m) suitable small sample sizes (n < 104); X-LDR, stochastic algorithm O(nmB) biobank-scale data (B iterations); n the size, and m number SNPs. These methods can refine entire genome into high-resolution grids, such as more...

Every distinct liver enzyme biomarker exhibits a strong correlation with non-alcoholic fatty disease (NAFLD). This study aims to comprehensively analyze and compare the associations of alanine aminotransferase (ALT), aspartate (AST), gamma-glutamyl transferase (GGT) NAFLD from gender perspective. was conducted on 6,840 females 7,411 males NAGALA cohort. Multivariable logistic regression analysis used between markers in both genders, recording corresponding adjusted odds ratios (ORs) 95%...

Background However, whether the whole-brain functional network hub changes occur in diabetic retinopathy patients remains unknown. Purpose The purpose of study was to investigate function centrality and connectivity using voxel-wise degree method. Materials methods Thirty-four (18 male 16 female) 38 healthy controls 20 closely matched age, sex, education were enrolled study. Graph theory-based analysis performed between two groups. Results Compared with controls, had significantly higher...

<title>Abstract</title> Background During public health emergencies such as SARS, Ebola, and COVID-19, healthcare workers (HCWs) are often required to confront these crises, potentially leading adverse mental outcomes. Consequently, they at a heightened risk of experiencing symptoms depression anxiety. It is widely recognized that psychological disorders can lead severe consequences. Despite this, there remains scarcity research focused on developing predictive models forecast the anxiety...

Objectives To determine the typical corneal changes in pure microphthalmia using a topography system and identify characteristics that may assist early diagnosis. Methods Patients with healthy control subjects underwent analysis (Orbscan IIZ® Corneal Topography System; Bausch Lomb, Bridgewater, NJ, USA) to degree of astigmatism (mean A), simulation (sim mean keratometry K), simulated irregularities 3 - 5-mm zone, thickness nine distinct regions. Results ( n = 12) had significantly higher K,...

Comitant exotropia (CE) is a common eye disease with abnormal movement, whereas altered synchronous neural activity in CE patients poorly understood. The purpose of our study was to investigate local remote functional connectivity blood oxygen level-dependent (BOLD) signals changes patients.Thirty-four and thirty-four healthy controls (HCs) underwent resting-state MRI scans. ReHo FC method applied the patients.Compared HC group, showed significant increased values left cerebellar_crus2...