Previous studies have demonstrated that strabismus or amblyopia can result in markedly brain function and anatomical alterations. However, the differences spontaneous activities of with (SA) patients still remain unclear. This current study intended to use amplitude low-frequency fluctuation (ALFF) technique investigate intrinsic activity changes SA subjects.A total 16 (6 males 10 females) healthy controls (HCs; 6 similarly matched age, gender, education status were recruited examined...

Abstract Objective Neuroimaging studies have shown that patients with pain‐related conditions altered neuronal activity and structural functions. The purpose of this study was to investigate whether classical trigeminal neuralgia ( CTN ) exhibit changes in corresponding via analysis regional homogeneity (ReHo). Methods A total 28 presenting sore eyes (12 men 16 women) were matched healthy controls women). All participants underwent functional magnetic resonance imaging fMRI ). This ReHo...

Objective: Breast cancer is the most common primary lesion resulting in intraocular metastasis (IOM). In this study, we investigated differences between breast patients with and without IOM, clarified risk factors for IOM cancer. Methods: A total of 2,381 were included study from January 2005 to December 2017. The chi-square test Student's t-test applied evaluate non-IOM (NIOM) groups. Risk calculated using binary logistic regression analysis. Receiver operating curve (ROC) analysis was used...

Background Neuroimaging studies revealed that trigeminal neuralgia was related to alternations in brain anatomical function and regional function. However, the functional characteristics of network organization whole is unknown. Purpose The aim present study analyze potential brain-activity changes their relationships with clinical features patients via voxel-wise degree centrality method. Material Methods This involved a total 28 (12 men, 16 women) healthy controls matched sex, age,...

Recent studies have reported structural and functional abnormalities in multiple brain regions of classical trigeminal neuralgia (CTN) patients. Differences spontaneous neuronal activity between CTN patients healthy subjects, however, remain unknown. The aim the present study was to investigate alterations by application amplitude low frequency fluctuation (ALFF), thus analyzing correlation durations pain intensity ALFF values A total 28 (male, n=12; female, n=16) controls (HCs; male,...

// Yi Shao 1, * , Jing Bao Xin Huang 2 Fu-Qing Zhou 3 Lei Ye 1 You-Lan Min Lin Yang Zubin Sethi 4 Qing Yuan and Qiong Department of Ophthalmology, The First Affiliated Hospital Nanchang University, 330006, Jiangxi, China People's Hubei Province, Wuhan 430060, Hubei, Radiology, University Miami, Florida 33146, USA These authors contributed equally to this work Correspondence to: Zhou, email: 375135747@qq.com Keywords: monocular blindness; voxel-mirrored homotopic connectivity; resting state;...

To investigate the potential regional homogeneity (ReHo) brain activity changes in patients with corneal ulcer (CU) and their possible relationship clinical symptoms.Forty CU (26 men 14 women), 40 healthy controls (HCs) women) closely matched age, sex, weight underwent resting-state functional MRI scans, respectively. The ReHo method was applied to evaluate synchronous neural changes. Receiver operating characteristic curve (ROC curve) used show high test-retest stability degree of...

The aim of the present study was to explore amplitude low‑frequency fluctuations (ALFF; a measurement spontaneous brain activity) in different regions patients with retinal vein occlusion (RVO) and its association vision changes measurements. A total 24 RVO (12 males 12 females) healthy controls (HCs, were recruited, they closely matched regarding age, gender education level (classified according nine‑year compulsory China higher education, all including primary school, junior high school...

Background . Exophthalmos occurs in patients with primary hyperthyroidism. There were few studies about the changes of brain functional networks exophthalmos hyperthyroidism (EOPH). However, differences spontaneous activity EOPH remain unclear. Objective This study explored alterations using a voxel-wise degree centrality (DC) method. Methods A total 20 (8 men and 12 women) enrolled. In addition, without exophthalmos, matched age, sex, education status, enrolled as control group. The...

The aim of the present study was to investigate altered spontaneous brain activity in patients with corneal ulcer (CU) through amplitude low-frequency fluctuation (ALFF) technique and association their visual performance. A total 40 CU healthy controls (HCs) matched for sex, age educational level were enrolled. Resting-state functional magnetic resonance imaging (rs-fMRI) performed examine probands. Spontaneous cerebral variations investigated using ALFF technique. average values HCs...

To evaluate functional connection density (FCD) in patients with diabetic optic neuropathy (DON) using the resting connectivity (FC) method, and to determine abnormal areas of brain activity.Patients DON (n=22; 10 male, 12 female) healthy controls (HCs; n=22; were included study. The basic characteristics groups matched. Functional magnetic resonance imaging (fMRI) was conducted participants at rest, long- short-range FCD (long IFCD, respectively) measured. Receiver operating characteristic...

The targets of this study were to access the alternations spontaneous brain activity in RD patients by amplitude low-frequency fluctuation (ALFF) method and explore their relationships with clinical behavioral performance.A total 20 (6 males 14 females), healthy controls (HCs) females) recruited, matched sex age. All participants finished functional magnetic resonance imaging (fMRI) scanning. We applied ALFF detect activity. Receiver operating characteristic (ROC) curve was distinguish...

Background: The results of previous studies have indicated that pain-associated diseases can result in marked functional and anatomical alterations the brain. However, differences spontaneous brain activity occurring toothache (TA) patients remain unclear. Objective: This study investigated intrinsic changes TA subjects using amplitude low-frequency fluctuation (ALFF) technique. Methods: A total 18 with (eight males, 10 females) healthy controls (HCs) who were matched for gender, age,...

To study the changes of resting state functional connectivity (rsFC) between acute eye pain (EP) subjects and healthy controls (HCs) in two hemispheres by using voxel-mirrored homotopic (VMHC) method.Totally 20 patients with EP HCs were enrolled, sex, age, education matched, all examined magnetic resonance imaging (fMRI) scans at resting-state. The rsFC evaluated VMHC method according to Gaussian random field (GRF) theory. In order identify VMHC, as biomarkers for distinguishing from HC,...

To investigate alternations in spontaneous brain activities reflected by functional connectivity density (FCD) patients with corneal ulcer (CU) using resting-state (rsFC).We recruited 24 CU (12 males, 12 females), and healthy controls (HCs; females) matched for age, gender education status. Functional magnetic resonance imaging examinations were performed on all subjects a resting state the following parameters determined: rsFC, long-range FCD (longFCD) short-range (IFCD). Receiver operating...

Abstract Objective To study the changes in gray matter volume (GMV) patients with advanced monocular blindness (MB) using voxel‐based morphometry (VBM). Methods Thirty‐one MB (25 males and six females) 31 normal controls were enrolled. The t test was applied to determine differences GMV, white (WMV), of cerebrospinal fluid different regions brain. local characteristics spontaneous concentrations brain tissue evaluated by VBM method. effects duration on GMV correlation regression analyses....

BackgroundCorneal ulcer (CU) is the second ocular disease leading to blindness. Millions of people around world suffer from CU. However, relationship between CU and altered functional connectivity in brain still unknown. PurposeThe aim present study was investigate alterations interhemispheric (FC) patients with using voxel-mirrored homotopic (VMHC) method their clinical manifestations. Material MethodsThe involved 24 (12 men, 12 women) healthy controls (HCs) age, sex, weight closely...

To investigate the differences of spontaneous functional connectivity (FC) primary visual cortex (V1) between patients with retinal vein occlusion (RVO) and healthy controls (HCs) using resting-state magnetic resonance imaging (rs-fMRI) data.Twenty-one RVO in total (11 males, 10 females) 21 HCs similarly analogue age sex background were enrolled inspected rs-fMRI. The difference FC V1 two groups compared two-sample t-test. We used receiver operating characteristic (ROC) curve to distinguish...

The purpose was to investigate the differences in spontaneous functional connectivity (FC) of primary visual cortex (V1) between patients with neovascular glaucoma (NVG) and healthy controls (HCs) using resting-state magnetic resonance imaging data.A total 18 NVG (nine males nine females) HCs similar age sex background were enrolled study inspected imaging. FC V1 two groups compared independent samples t-test. We used receiver operating characteristic (ROC) curve compare average values...