The outbreak of coronavirus disease 2019 (COVID-19) is having a dramatic effect on the mental health healthcare workers (HCWs). Upon emergence COVID-19 pandemic, Chinese government dispatched about 42 000 HCWs to Wuhan City and Hubei Province fight this pandemic. This study briefly examines front-line nurses who experienced burnout, with main objective investigating mediating roles positive negative affect in relationship between resilience burnout hospitals at peak A total 180 voluntarily...

Vaccine hesitancy, associated with medical mistrust, confidence, complacency and knowledge of vaccines, presents an obstacle to the campaign against coronavirus disease 2019 (COVID-19). The relationship between vaccine hesitancy conspiracy beliefs may be a key determinant success vaccination campaigns. This study provides conceptual framework explain impact pathways from COVID-19 regard vaccines.A non-probability was conducted 1015 respondents 17 April 28 May 2021. Conspiracy were measured...

Objective To investigate the underlying functional network brain-activity changes in patients with adult comitant exotropia strabismus (CES) and relationship clinical features using voxel-wise degree centrality (DC) method. Methods A total of 30 CES (17 men, 13 women), healthy controls (HCs; 17 women) matched age, sex, education level participated study. DC was used to evaluate spontaneous brain activity. Receiver operating characteristic (ROC) curve analysis conducted distinguish CESs from...

Diabetic retinopathy (DR) is a serious ophthalmopathy that causes blindness, especially in the proliferative stage. However, pathogenesis of its effect on endothelial cells, relationship with immune cell infiltration, remains unclear.The dataset GSE94019 was downloaded from Gene Expression Omnibus (GEO) database to obtain DEGs. Through aggregate analyses such as Ontology (GO) and Kyoto Encyclopedia Genome (KEGG) pathway enrichment analysis, protein-protein interaction (PPI) network...

// Yi Shao 1, * , Jing Bao Xin Huang 2 Fu-Qing Zhou 3 Lei Ye 1 You-Lan Min Lin Yang Zubin Sethi 4 Qing Yuan and Qiong Department of Ophthalmology, The First Affiliated Hospital Nanchang University, 330006, Jiangxi, China People's Hubei Province, Wuhan 430060, Hubei, Radiology, University Miami, Florida 33146, USA These authors contributed equally to this work Correspondence to: Zhou, email: 375135747@qq.com Keywords: monocular blindness; voxel-mirrored homotopic connectivity; resting state;...

This study investigated the changes in interhemispheric functional connectivity (FC) of whole brain open globe injury (OGI) patients, using voxel-mirrored homotopic (VMHC), and their relationships with clinical features. Totally, 16 male 2 female acute OGI patients 18 sex, age, education-matched healthy volunteers were enrolled study. All subjects scanned through magnetic resonance imaging (fMRI). Receiver operating characteristic (ROC) curves analyses had been used to identify VMHC these...

BACKGROUND Diabetic retinopathy (DR) is a major ocular complication of diabetes mellitus, leading to visual impairment. Retinal pigment epithelium (RPE) injury key component the outer blood retinal barrier, and its damage an important indicator DR. Receptor for activated C kinase 1 (RACK1) activates protein C-ε (PKC-ε) promote generation reactive oxygen species (ROS) in RPE cells, apoptosis. Therefore, we hypothesize that activation RACK1 under hypoxic/high-glucose conditions may cell...

Research on the specific pathways from maternal nurturance to early child development remains limited. Grounded in transactional theory, this study is first examine these through parent-child relationship.

Background We know little about the changes of brain activity in patients with normal-tension glaucoma (NTG). Purpose To investigate altered spontaneous NTG through resting state functional magnetic resonance imaging–fractional amplitude low-frequency fluctuation (rsfMRI-fALFF) technique, and to explore relationship optical coherence tomography (OCT) field vision. Material Methods Twenty 20 healthy controls (HCs) (matched for sex, age, level education) were enrolled. Spontaneous cerebral...

Abstract Background This study aimed to examine the direct and indirect pathways from childhood socioeconomic status (SES) prevalence of edentulism in mid-to-late age Chinese individuals using structural equation modeling (SEM). Methods analyzed data 17,032 mid- to-late 2014 2015 China Health Retirement Longitudinal Study (CHARLS). Childhood SES was determined based on parents’ education occupation, financial situation family, primary residence, food availability, medical convenience....

To investigate the prognostic value of neutrophil-to-lymphocyte ratio (NLR) in patients with diabetic macular edema (DME) treated monthly ranibizumab. We retrospectively analyzed medical records all who received intravitreal ranibizumab (IVR) treatment for DME at First Affiliated Hospital Nanchang University between December 2015 and 2017. Clinicopathological parameters, including NLR, were evaluated to identify predictors better outcomes IVR monotherapy. Ninety-one treatment-naïve eyes this...

The purpose of this project is to make sequential and indepth observation the variations retinal microvascular, microstructure, inflammatory mediators at early stage diabetic retinopathy (DR) in streptozotocin-induced diabetes mellitus (DM) rats. DM was induced by a single intraperitoneal injection 60 mg/kg body weight streptozotocin (STZ). fluorescein fundus angiography, hematoxylin eosin staining, periodic acid-Schiff fluorescence imaging techniques, quantitative real-time PCR, vascular...

The aim of the present study was to explore amplitude low‑frequency fluctuations (ALFF; a measurement spontaneous brain activity) in different regions patients with retinal vein occlusion (RVO) and its association vision changes measurements. A total 24 RVO (12 males 12 females) healthy controls (HCs, were recruited, they closely matched regarding age, gender education level (classified according nine‑year compulsory China higher education, all including primary school, junior high school...

Childhood eating behaviors and temperament may have important implication for constructing the pathways from maternal feeding practices to childhood overweight obesity (OW/OB). Examining multiple styles simultaneously OW/OB is critical through mediators of early behaviors.This cross-sectional study recruited mothers mainly responsible child care two hospitals healthcare centers in eastern China. Sociodemographic characteristics, data Infant Feeding Style Questionnaire (IFSQ), short form...

Abstract The relationship between childhood socioeconomic status (SES) and type 2 diabetes (T2D) remains inconclusive, the pathways mechanisms driving this have yet to be clarified. This study aimed examine linking SES T2D prevalence in mid-late adulthood a low- middle-income country. incidence of diagnosed Chinese was assessed using self-reports from Health Retirement Longitudinal Study (CHARLS). Childhood by education, occupation, survivorship parents financial situation family, whereas...

The targets of this study were to access the alternations spontaneous brain activity in RD patients by amplitude low-frequency fluctuation (ALFF) method and explore their relationships with clinical behavioral performance.A total 20 (6 males 14 females), healthy controls (HCs) females) recruited, matched sex age. All participants finished functional magnetic resonance imaging (fMRI) scanning. We applied ALFF detect activity. Receiver operating characteristic (ROC) curve was distinguish...

The purpose was to investigate the differences in spontaneous functional connectivity (FC) of primary visual cortex (V1) between patients with neovascular glaucoma (NVG) and healthy controls (HCs) using resting-state magnetic resonance imaging data.A total 18 NVG (nine males nine females) HCs similar age sex background were enrolled study inspected imaging. FC V1 two groups compared independent samples t-test. We used receiver operating characteristic (ROC) curve compare average values...

Neovascular glaucoma (NVG) is a secondary refractory disease with poor prognosis, and there are few advanced studies on its pathogenesis treatment. In this research, the fractional amplitude of low-frequency fluctuation (fALFF) technology was used in resting-state functional magnetic resonance imaging (rsfMRI) to investigate intrinsic neuron activity patient's brain NVG.Sixteen patients NVG (eight males eight females) 16 healthy controls (HCs) similar age sex were included. All received...

Diabetic optic neuropathy (DON) is a diverse complication of diabetes and its pathogenesis has not been fully elucidated. The purpose this study was to explore dynamic cerebral activity changes in DON patients using amplitude low-frequency fluctuation (dALFF). In total, 22 healthy controls were enrolled. dALFF approach used all participants investigate intrinsic brain differences between the two groups. Compared with HCs, exhibited significantly increased variability right middle frontal...

Background Diabetic vitreous hemorrhage (DVH) is a common complication of diabetes. While the diagnostic methods nowadays only concentrate on eye injury in DVH patients, whether leads to abnormalities other visual systems, including eye, cortex, and brain regions, remains unknown. Aim To explore potential changes activity using regional homogeneity (ReHo) their relationships with clinical features. Methods Thirty-one patients 31 matched healthy controls (HCs) were recruited. All subjects...

Abstract Objective Middle‐age patients with retinal detachment (RD) exhibit a loss of visual information, and previous studies functional magnetic resonance imaging (fMRI) have demonstrated abnormal spontaneous activity in the RD brain. Therefore, this study assessed changes local connectivity density (lFCD) long‐range (longFCD) middle‐age during resting‐state FC. Methods In total, 32 (18 men 14 women), age‐, sex‐, education‐matched normal controls (NCs) women) were recruited underwent...

The aim of the present study was to investigate effect intravitreal injection ranibizumab on retinal ganglion cells and microvessels at early stage diabetic retinopathy (DR) in rats with streptozotocin-induced diabetes mellitus (DM). DM induced by a single intraperitoneal 60 mg/kg body weight streptozotocin. A total 80 were randomly assigned four treatment groups (n=20 each group) treated an oculus dexter ranibizumab. Groups B injected two weeks after DM‑induction, respectively, while b...

In this study, the regional homogeneity (ReHo) method was used to investigate levels of cerebral in individuals with age-related macular degeneration (AMD), aim exploring whether these measures are associated clinical characteristics.Patients AMD and healthy controls attending First Affiliated Hospital Nanchang University were invited participate. Resting state functional magnetic resonance images recorded each participant synchronous neural activity evaluated using ReHo. Receiver operating...

Abstract Three-dimensional phononic crystals based on the locally resonant structure were fabricated in this work. The effects of physical properties scatterer and matrix acoustic absorption coefficient (AAC) investigated via calculational experimental methods simultaneously. consistency results was examined. Two kinds backing standing wave tube, air steel-air backing, used to validate changing discipline AAC. suggested that location, extension intensity peak had close relationship with...