A5067617091- Growth Hormone and Insulin-like Growth Factors
- Birth, Development, and Health
- Health and Medical Research Impacts
- Healthcare professionals’ stress and burnout
- Job Satisfaction and Organizational Behavior
- Diabetes and associated disorders
- Innovations in Medical Education
- Pancreatic function and diabetes
- Adipose Tissue and Metabolism
- COVID-19 Clinical Research Studies
- Workaholism, burnout, and well-being
- Advanced Neuroimaging Techniques and Applications
- Cancer, Hypoxia, and Metabolism
- Neuroendocrine regulation and behavior
- Metabolism, Diabetes, and Cancer
- Resilience and Mental Health
- Liver Disease Diagnosis and Treatment
- Prostate Cancer Diagnosis and Treatment
- Hypothalamic control of reproductive hormones
- Cytokine Signaling Pathways and Interactions
- Work-Family Balance Challenges
- Adipokines, Inflammation, and Metabolic Diseases
- Alzheimer's disease research and treatments
- Health disparities and outcomes
- Gout, Hyperuricemia, Uric Acid
Air Force Medical University
2024-2025
Hangzhou Center for Disease Control and Prevention
2025
Zhejiang Chinese Medical University
2022-2025
Harbin Medical University
2025
Shaanxi University of Chinese Medicine
2024
Northeast Agricultural University
2024
Clemson University
2024
Beijing University of Chemical Technology
2024
Hangzhou Hospital of Traditional Chinese Medicine
2020-2024
University of Hong Kong
2014-2023
Exercise is an effective nonpharmacological strategy to alleviate diabetic cardiomyopathy (DCM) through poorly defined mechanisms. FGF21 (fibroblast growth factor 21), a peptide hormone with pleiotropic benefits on cardiometabolic homeostasis, has been identified as exercise responsive factor. This study aims investigate whether signaling mediates the of DCM, and if so, elucidate underlying The global or hepatocyte-specific knockout mice, cardiomyocyte-selective β-klotho (the obligatory...
To detect white matter abnormalities in patients with mild Alzheimer disease (AD) by diffusion tensor imaging and to determine their topographic relationship gray atrophy.Thirteen AD 16 normal age-matched volunteers underwent three-dimensional spoiled gradient-recalled sequence scanning. Voxel-based morphometry was conducted regions of atrophy the group relative control group. Fractional anisotropy (FA) maps were processed using SPM2 make voxel-wise comparison whole brain between two groups....
Generation of widely differing and specialized cell types from a single totipotent zygote involves large-scale transcriptional changes chromatin reorganization. Pioneer transcription factors play key roles in programming the epigenome facilitating recruitment additional regulatory during successive lineage specification differentiation steps. Here we show that Isl1 acts as pioneer factor driving cardiomyocyte commitment by shaping landscape cardiac progenitor cells. Using an hypomorphic...
Regulatory T cells (Tregs) and B present in gut-associated lymphoid tissues (GALT) are both implicated the resolution of colitis. However, how functions these coordinated remains elusive. We used dextran sulfate sodium (DSS)-induced colitis model combined with gene-modified mice to monitor progression colitis, simultaneously examine number Tregs cells, production IgA antibodies. found that DSS-treated exhibited more severe absence adoptive transfer attenuated disease. Moreover, IL-10−/− also...
The outbreak of coronavirus disease 2019 (COVID-19) is having a dramatic effect on the mental health healthcare workers (HCWs). Upon emergence COVID-19 pandemic, Chinese government dispatched about 42 000 HCWs to Wuhan City and Hubei Province fight this pandemic. This study briefly examines front-line nurses who experienced burnout, with main objective investigating mediating roles positive negative affect in relationship between resilience burnout hospitals at peak A total 180 voluntarily...
ABSTRACT Background The outbreak of a new coronavirus (SARS-CoV-2) disease (Covid-19) has become pandemic. To be more effectively controlling the disease, it is critical to set up an optimal quarantine period so that about 95% cases developing symptoms will retained for isolation. At moment, WHO-established 14 days based on previous reports which had studied small sizes hospitalized (10 and ∼100, respectively), however, over 80% adult- child-cases were not necessary stay in hospitals,...
Abstract Mitochondrial metabolism is pivotal for glucose-stimulated insulin secretion (GSIS) in pancreatic β-cells. However, little known about the molecular machinery that controls homeostasis of intermediary metabolites mitochondria. Here we show activation p53 β-cells, by genetic deletion or pharmacological inhibition its negative regulator MDM2, impairs GSIS, leading to glucose intolerance mice. Mechanistically, represses expression mitochondrial enzyme pyruvate carboxylase (PC),...
ICU nurses frequently confront lengthy working hours, elevated job intensity, heavy medical responsibilities, round-the-clock shifts, and a comparatively closed environment. The high-risk, high-intensity, high-stress nature of the profession may prompt to consider resignation, culminating in significant shortage nursing staff, adversely affecting health well-being nurses. Necessitating comprehensive investigation into factors influencing their subjective interrelations among these factors,...
A fiber-tracking algorithm was used to extract fractional anisotropy of bilateral cingulum bundles in patients with probable Alzheimer's disease and normal aging controls. In addition, their hippocampal volumes were measured manually. Relative controls, showed a significant reduction volumes. Significant correlation observed between values hippocampi mini-mental state examination scores. This study suggests that lower is associated cognitive dysfunction atrophy the limbic system.
The nursing workforce shortage has long been a global concern, and with the aging of nurses, this problem become more prominent. Nursing is recognized as high-stress occupation, nurses experience high levels job burnout, which reduces their professional identity. Older are an indispensable talent force for teams extremely important stability improvement in quality. Exploring mental health influencing factors older very beneficial development nurse patients' clinical outcomes.This study aimed...
Aims Hyperuricaemia is associated with the development of Diabetic kidney disease (DKD). However, mechanism hyperuricaemia causing progression DKD remain unclear. Methods This a single-centre retrospective study. 155 biopsy-proven patients were grouped into and non-hyperuricaemia groups. Kaplan-Meier analysis landmark curves performed to explore predictors end-stage renal (ESRD), Cox regression was used screen for factors, nomogram constructed predict prognosis DKD. Results Patients in group...
ABSTRACT Atherosclerosis (AS) is the basis of cardiovascular diseases (CVDs) and remains major contributor to death worldwide. Capsiate derived from sweet pepper fruit exhibits numerous pharmacological activities. The objective this study was elucidate protective role capsiate in atherosclerosis by examining its effect underlying regulatory pathways. Here, we showed that treatment alleviates atherosclerosis-prone apolipoprotein E-deficient (ApoE −/− ) mice. We found effectively reduced...
Objective: This randomized controlled trial compared the intraoperative performance, postoperative safety profiles, and clinical outcomes between modified ultrasound-guided percutaneous dilatational tracheostomy (US-PDT) conventional fiberoptic bronchoscopy-assisted PDT (FB-PDT) in critically ill patients within Emergency Intensive Care Unit (EICU), aiming to establish an optimized protocol for high-risk populations. Methods: Between January 2023 March 2025, 72 consecutive intubated...
Introduction Psychological distress in patients with pituitary adenomas affects their quality of life and is influenced by various aspects such as sociocultural factors, personal resources, stressors. Therefore, the aim this study was to investigate chain-mediated role self-efficacy rumination relationship between social support psychological distress. Methods The based on Wilson-Cleary model health-related theory. We investigated 500 surgically treated three tertiary hospitals Shaanxi...