A5060507935- Radiomics and Machine Learning in Medical Imaging
- Hepatocellular Carcinoma Treatment and Prognosis
- MRI in cancer diagnosis
- Gastric Cancer Management and Outcomes
- Cancer, Hypoxia, and Metabolism
- Pancreatic and Hepatic Oncology Research
- Renal cell carcinoma treatment
- Glaucoma and retinal disorders
- Cancer, Lipids, and Metabolism
- Retinal Diseases and Treatments
- Ovarian cancer diagnosis and treatment
- Esophageal and GI Pathology
- Ocular Diseases and Behçet’s Syndrome
- Vascular Procedures and Complications
- Genetic factors in colorectal cancer
- Esophageal Cancer Research and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Central Venous Catheters and Hemodialysis
- Aortic aneurysm repair treatments
- Radiopharmaceutical Chemistry and Applications
- Cancer Mechanisms and Therapy
- Cancer Research and Treatments
- Abdominal vascular conditions and treatments
- Ophthalmology and Visual Impairment Studies
- Immune cells in cancer
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Affiliated Hospital of North Sichuan Medical College
2013-2024
First Affiliated Hospital of Jiangxi Medical College
2024
Nanchang University
2024
North Sichuan Medical University
2009-2024
Sichuan University
2023-2024
West China Hospital of Sichuan University
2024
Henan Normal University
2024
First Affiliated Hospital of Nanchang University
2024
Huazhong University of Science and Technology
2024
Abstract Purpose: This phase I trial was undertaken to determine the maximum tolerated dose (MTD), dose-limiting toxicities (DLT), safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary antitumor activity of novel smoothened inhibitor sonidegib (LDE225), a potent hedgehog signaling, in patients with advanced solid tumors. Experimental Design: Oral administered 103 tumors, including medulloblastoma basal cell carcinoma (BCC), at doses ranging from 100 3,000 mg daily 250 750...
Abstract The purpose of this study was to explore the effectiveness radiomics based on multisequence MRI in predicting expression PD-1/PD-L1 hepatocellular carcinoma (HCC). One hundred and eight patients with HCC who underwent contrast-enhanced 2 weeks before surgical resection were enrolled retrospective study. Corresponding paraffin sections collected for immunohistochemistry detect PD-1 PD-L1. All randomly divided into a training cohort validation at ratio 7:3. Univariate multivariate...
Hepatocellular carcinoma (HCC) is the sixth most common malignant tumour and third leading cause of cancer death in world. The emerging field radiomics involves extracting many clinical image features that cannot be recognized by human eye to provide information for precise treatment decision making. Radiomics has shown its importance HCC identification, histological grading, microvascular invasion (MVI) status, response, prognosis, but there no report on preoperative prediction programmed...
Phosphodiesterase 4 (PDE4) inhibitors are effective therapeutic agents for various inflammatory diseases. Roflumilast, apremilast, and crisaborole have been developed approved the treatment of chronic obstructive pulmonary disease psoriatic arthritis, atopic dermatitis. Inflammation underlies many vascular diseases, yet role PDE4 in these diseases remains inadequately explored. This review elucidates clinical applications anti-inflammatory mechanisms inhibitors, as well their potential...
Results of the global, randomized, phase 3 KEYNOTE-859 study (N = 1579) showed that first-line pembrolizumab plus chemotherapy produced a statistically significant and clinically meaningful improvement in overall survival (OS) with manageable toxicity versus placebo patients locally advanced or metastatic human epidermal growth factor receptor 2 (HER2)–negative gastric gastroesophageal junction cancer. This subgroup analysis was conducted to investigate outcomes enrolled mainland China....
9030 Background: Uveal melanoma is characterized by frequent mutations in GNAQ or GNA11 that encode for G-protein α-subunits (Gα) which mediate signaling from coupled receptors to downstream pathways, including PKC. AEB071 (sotrastaurin) a potent, selective oral inhibitor of the classical (α, β), and novel (δ, ε, η, θ) isoforms Preclinical data shows sensitivity Gα mutant uveal cell lines AEB071. Methods: An open-label, multicenter, single-arm, Phase I study was performed pts (WHO...
Differences between the features of primary cancer and matched metastatic have recently drawn attention in research. This study investigated concordance microsatellite instability (MSI) mismatch repair (MMR) status corresponding colorectal (CRC).Consecutive patients with CRC who had both tumors diagnosed at our institution January 2008 through December 2016 were identified. Immunohistochemistry was used to test MMR tumors, PCR analysis performed MSI deficient (dMMR) status.A total 369...
Abstract The present study aimed to explore the value of intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) in differentiating hepatocellular carcinoma (HCC) from intrahepatic cholangiocarcinoma (ICC). This included 65 patients with malignant hepatic nodules (55 HCC, 10 ICC), and 17 control normal livers. All underwent IVIM-DWI scans on a 3.0 T magnetic resonance (MRI) scanner. standard apparent diffusion coefficient (ADC), pure (D slow ), pseudo-diffusion fast perfusion...
Abstract Objective The purpose of this study was to investigate the ability radiomic characteristics magnetic resonance images predict vascular endothelial growth factor (VEGF) expression in hepatocellular carcinoma (HCC) patients. Methods One hundred and twenty-four patients with HCC who underwent fat-suppressed T2-weighted imaging (FS-T2WI) dynamic contrast-enhanced (DCE-MRI) one week before surgical resection were enrolled retrospective study. Immunohistochemical analysis used evaluate...
Background Computed tomographic (CT) perfusion imaging has been applied in many clinical areas, but few studies have addressed the values of CT evaluating therapeutic response chemoembolization for hepatocellular carcinoma (HCC). Objective To assess changes HCC after transarterial chemoembolization, and to investigate procedure. Methods Multidetector computed was performed 24 patients with 1 week before 4 weeks chemoembolization. The parameters, including hepatic arterial (HAP), portal...
The purpose of this study was to investigate the efficacy magnetic resonance imaging (MRI) radiomics in differentiating hepatocellular carcinoma (HCC) from intrahepatic cholangiocarcinoma (ICC). clinical and MRI data 129 pathologically confirmed HCC patients 48 ICC treated at Affiliated Hospital North Sichuan Medical College between April 2016 December 2021 were retrospectively analyzed. randomly divided a ratio 7:3 into training group 124 (90 with 34 ICC) validation 53 (39 14 ICC). Radiomic...
Abstract The present study aimed to investigate the value of intravoxel incoherent motion diffusion weighted imaging (IVIM-DWI) in preoperative prediction histologic differentiation hepatocellular carcinoma (HCC). Seventy HCC patients were scanned with a 3.0 T magnetic resonance scanner. values apparent coefficient (ADC), slow (D), fast (D*), and fraction (f) measured. Analysis variance was used compare differences parameters between groups different degrees differentiation. p < 0.05...
BACKGROUND Diabetic retinopathy (DR) is a major ocular complication of diabetes mellitus, leading to visual impairment. Retinal pigment epithelium (RPE) injury key component the outer blood retinal barrier, and its damage an important indicator DR. Receptor for activated C kinase 1 (RACK1) activates protein C-ε (PKC-ε) promote generation reactive oxygen species (ROS) in RPE cells, apoptosis. Therefore, we hypothesize that activation RACK1 under hypoxic/high-glucose conditions may cell...
Abstract Previous research has produced inconsistent findings concerning the connection between metabolic syndrome and prostate cancer. It is challenging for observational studies to establish a conclusive causal relationship two. However, Mendelian randomization can provide stronger evidence of causality in this context. To examine link composite its components with cancer, we performed two-sample (MR) study utilizing aggregated data from genome-wide association studies, followed by...
Hepatocellular carcinoma (HCC) is the fourth most common cause of cancer-related death worldwide. Angiogenic factors may be valuable indices tumor recurrence and treatment potentially useful markers for predicting response to antiangiogenesis therapy. Vascular endothelial growth factor (VEGF) matrix metalloproteinases (MMPs) are major drivers angiogenesis. Preoperatively expression VEGF MMPs crucial treating HCC. Intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) has been...
Abstract Background Hepatocellular carcinoma (HCC) is the sixth most common cancer, and third leading cause of cancer death worldwide. Studies have shown that increased angiopoietin-2 (Ang-2) expression relative to Ang-1 in tumors associated with a poor prognosis.The purpose this study was investigate efficacy predicting Ang-2 HCC by preoperative dynamic contrast‐enhanced magnetic resonance imaging (DCE-MRI)-based radiomics. Methods The data 52 patients who underwent surgical resection our...