A5104053530- Muscle Physiology and Disorders
- Genetic Neurodegenerative Diseases
- Viral Infections and Immunology Research
- Cardiomyopathy and Myosin Studies
- Cardiovascular Function and Risk Factors
- Viral gastroenteritis research and epidemiology
- Cardiac Fibrosis and Remodeling
- Diabetes and associated disorders
- Peptidase Inhibition and Analysis
- Mitochondrial Function and Pathology
- Diabetes Management and Research
- Lower Extremity Biomechanics and Pathologies
- Shoulder Injury and Treatment
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Regulation of Appetite and Obesity
- Sleep and Wakefulness Research
- Knee injuries and reconstruction techniques
- Animal Disease Management and Epidemiology
- Gastric Cancer Management and Outcomes
- Metabolism, Diabetes, and Cancer
- Pancreatic function and diabetes
- Retinoids in leukemia and cellular processes
- Diabetes Treatment and Management
- Pharmacological Effects of Natural Compounds
- Animal Virus Infections Studies
Zhongshan Hospital of Xiamen University
2025
First Affiliated Hospital of Fujian Medical University
2019-2025
Fujian Medical University
2013-2025
Union Hospital
2013-2024
Yantaishan Hospital
2023
Decision Sciences (United States)
2023
First Affiliated Hospital of Xiamen University
2021-2022
Shandong Agricultural University
2020-2022
Daqing Oilfield General Hospital
2018-2021
Shanghai Public Health Clinical Center
2021
In myotonic dystrophy (DM), expression of RNA containing expanded CUG or CCUG repeats leads to misregulated alternative splicing pre-mRNA. The repeat-bearing transcripts accumulate in nuclear foci, together with proteins the muscleblind family, MBNL1 and MBNL2. transgenic mice that express repeats, we show defect selectively targets a group exons share common temporal pattern developmental regulation. These undergo synchronized switch between post-natal day 2 20 wild-type mice. During this...
Genomic expansions of simple tandem repeats can give rise to toxic RNAs that contain expanded repeats. In myotonic dystrophy, the expression CUG (CUGexp) causes abnormal regulation alternative splicing and neuromuscular dysfunction. We used a transgenic mouse model show derangements dystrophy are reversed by morpholino antisense oligonucleotide, CAG25, binds CUGexp RNA blocks its interaction with muscleblind-like 1 (MBNL1), CUGexp-binding protein. CAG25 disperses nuclear foci reduces overall...
Myotonic dystrophy type 1 (DM1) is an RNA dominant disease in which mutant transcripts containing expanded CUG repeat (CUG(exp)) cause muscle dysfunction by interfering with biogenesis of other mRNAs. The toxic effects are mediated partly through sequestration splicing regulator Muscleblind-like (Mbnl1), a protein that binds to CUG(exp) RNA. A gene prominently affected encodes chloride channel (Clcn1), resulting hyperexcitability (myotonia). To identify DM1-affected genes and study...
Abstract Background Cardiac remodeling is one of the major risk factors for heart failure. In patients with type 2 diabetes, sodium–glucose cotransporter (SGLT2) inhibitors reduce first hospitalization failure, possibly through glucose-independent mechanisms in part, but underlying remain largely unknown. This study aimed to shed light on efficacy dapagliflozin reducing cardiac and potential mechanisms. Methods Sprague–Dawley (SD) rats, induced by chronic infusion Angiotensin II (Ang II) at...
The CB2 cannabinoid agonist LY2828360 lacked both toxicity and efficacy in a clinical trial for osteoarthritis. Whether suppresses neuropathic pain has not been reported, its signaling profile is unknown. In vitro, was slowly acting but efficacious G protein-biased agonist, inhibiting cAMP accumulation activating extracellular signal-regulated kinase 1/2 while failing to recruit arrestin, activate inositol phosphate signaling, or internalize receptors. wild-type (WT) mice, (3 mg/kg per day...
The disease mechanism underlying myotonic dystrophy type 1 (DM1) pathogenesis in skeletal muscle may involve sequestration of RNA binding proteins nuclear foci expanded poly(CUG) RNA. Here we report evidence for a parallel the heart. Accumulation is associated with muscleblind and abnormal regulation alternative splicing DM1 cardiac muscle. A toxic effect an repeat contribute to DM1.
Norovirus (NoV) is a positive-sense single-stranded RNA virus that causes acute gastroenteritis and responsible for 200,000 deaths per year worldwide. No effective vaccine or treatment available. Recent studies have shown the nucleoside analogs favipiravir (T-705) 2'-C-methyl-cytidine (2CM-C) inhibit NoV replication in vitro animal models, but their precise mechanism of action unknown. We evaluated molecular interactions between triphosphates RNA-dependent polymerase (NoVpol), enzyme...
Background Abnormal serum potassium is associated with an increased risk of mortality in dialysis patients. However, the impacts levels on short- and long-term association variability death peritoneal (PD) patients are uncertain. Methods We examined mortality-predictability at baseline its PD treated our center January 2006 through December 2010 follow-up 2012. The hazard ratios (HRs) were used to assess relationship between short-term (≤1 year) as well (>1 survival. Variability was defined...
Abstract Messenger RNA m 6 A modification is shown to regulate local translation in axons. However, how the codes axonal mRNAs are read and decoded by reader proteins still unknown. Here, it found that readers YTHDF1 YTHDF2 both expressed cerebellar granule cells (GCs) their Knockdown (KD) of or significantly increases GC axon growth rates vitro. By integrating anti‐YTHDF1&2 RIP‐Seq with quantitative proteomic analysis RNA‐seq after KD YTHDF2, a group transcripts which may mediate...
Allergic rhinitis is a common respiratory disease. Acupuncture used to treat it in traditional Chinese medicine, and generally, the L120, ST2 ST36 acupoints are selected clinical practice. We report new method of acupuncture at sphenopalatine acupoint (SPA) for treatment persistent allergic (PAR). The effect this was investigated using two different needling depths. efficacy associated with accurate stimulation ganglion (SPG). A total 61 patients diagnosed PAR were randomly allocated either...
ABSTRACT Objective To determine the value of lymphocyte subsets and granulocyte/monocyte surface markers in predicting risk post‐acute pancreatitis diabetes (PPDM‐A). Methods This study included 308 patients with acute (AP). The granulocytes monocytes were detected by flow cytometry, fluorescence intensity, absolute count percentage obtained. Based on occurrence after AP, divided into two groups: PPDM‐A PPNG‐A (post‐acute normal glucose). Correlations between granulocyte monocyte analyzed....
Background Early prediction of heart failure (HF) after acute myocardial infarction (AMI) is essential for personalized treatment. We aimed to use interpretable machine learning (ML) methods develop a risk model HF in AMI patients. Methods retrospectively included patients initially with who received percutaneous coronary intervention (PCI) our hospital from November 2016 February 2020. The primary endpoint was the occurrence within 3 years operation. For developing predictive patients,...
Abstract Aims Effective therapeutic drugs for calcific aortic valve disease (CAVD) are lacking, although its incidence has been increasing over the past decade, and is predicted to continue rising in future. This study aimed explore role potential mechanisms of liver X receptor α (LXRα) CAVD, which offers a promising approach treating CAVD. Methods results Osteogenic stimulation was performed following substantial downregulation LXRα observed human valves valvular interstitial cells. Further...
All members of the Caliciviridae family viruses produce a subgenomic RNA during infection. The typically encodes only major and minor capsid proteins, but in murine norovirus (MNV), also VF1 protein, which functions to suppress host innate immune responses. To date, mechanism synthesis has not been characterized. We have previously described presence an evolutionarily conserved stem-loop structure on negative-sense RNA, complementary sequence codes for viral RNA-dependent polymerase (NS7)....
Retinoid X receptor (RXR) has been demonstrated to play an important role in cardiac development and implicated cardiovascular diseases. This study aimed examine the effects of RXRα agonist bexarotene on pathological left ventricular hypertrophy (LVH) a spontaneously hypertensive rat (SHR) model underlying mechanism. WKY rats served as controls. SHRs were randomized into 3 groups at age 4 weeks treated (once daily for 12 weeks) with either (30 or 100mg/kg body weight) vehicle alone....