A5027135538- Microbial metabolism and enzyme function
- Cancer-related molecular mechanisms research
- Gastric Cancer Management and Outcomes
- Macrophage Migration Inhibitory Factor
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- Advanced Sensor and Energy Harvesting Materials
- Radiomics and Machine Learning in Medical Imaging
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Surgical Treatments
- Cancer, Hypoxia, and Metabolism
- Medical Image Segmentation Techniques
- Colorectal Cancer Screening and Detection
- Epigenetics and DNA Methylation
- Analytical Chemistry and Sensors
- Gastrointestinal Tumor Research and Treatment
- Cancer, Lipids, and Metabolism
- Gas Sensing Nanomaterials and Sensors
- Neutropenia and Cancer Infections
- Oral health in cancer treatment
- Neuroscience and Neural Engineering
- Microbial Metabolic Engineering and Bioproduction
- Circular RNAs in diseases
- Optical Imaging and Spectroscopy Techniques
- Cholangiocarcinoma and Gallbladder Cancer Studies
Peking University Shenzhen Hospital
2011-2025
The University of Texas Southwestern Medical Center
2023
University of Hong Kong - Shenzhen Hospital
2022-2023
Hong Kong University of Science and Technology
2022-2023
Hospital Nossa Senhora da Conceição
2023
Beijing Institute of Technology
2020-2022
Affiliated Hospital of Jining Medical University
2018
Affiliated Hospital of Zunyi Medical College
2017
Shantou University
2014-2016
Shantou University Medical College
2014-2016
As nitric oxide (NO) plays significant roles in a variety of physiological processes, the capability for real-time and accurate detection NO live organisms is great demand. Traditional assessments rely on indirect colorimetric techniques or electrochemical sensors that often comprise rigid constituent materials can hardly satisfy sensitivity spatial resolution simultaneously. Here, we report flexible highly sensitive biosensor based organic transistors (OECTs) capable continuous wireless...
Despite the effectiveness of chemotherapy and targeted therapy for colorectal cancer, drug resistance drives failure tumor relapse. Increasing evidence has suggested that cancer cells can enter a reversible drug-tolerant persister state to survive or agents. However, traits treatable vulnerabilities anti-colorectal is not yet known.In this study, we established 5-fluorouracil AZ628-tolerant cell models in two lines, namely HCT116 SW620, revealed characteristics by viability assay flow...
Thermometric detectors are crucial in evaluating the condition of target objects spanning from environments to human body. Optical-based thermal sensing tools have received extensive attention, which photon upconversion process with low autofluorescence and high tissue penetration depth is considered as a competent method for temperature monitoring, particularly biomedical fields. Here, we present an optoelectronic thermometer via infrared-to-visible upconversion, accomplished by integrated...
Shock waves are widely used to treat various diseases and have numerous medical applications. In particular, extracorporeal shock (ESV) can substantially inhibit tumour growth. However, the therapeutic efficacy of ESV in colorectal cancer its underlying mechanisms not well understood. To address this gap our knowledge, cell lines HT29 SW620 were generate xenograft mouse models examined effects a stepwise increase energy on vivo, 60 mJ significantly delayed growth compared with 120 240 ESV,...
Lysyl oxidase-like 2 (LOXL2) participates in every stage of cancer progression and promotes invasion metastasis. In this study, we identified a novel alternative splicing isoform LOXL2, namely LOXL2 Δe13, which lacked exon 13. Deletion 13 caused an open reading frame shift produced truncated protein. Δe13 was expressed ubiquitously cell lines tissues mainly localized to the cytoplasm. Although it showed impaired deamination enzymatic activity compared with full-length promoted mobility...
This paper proposes an adaptive window-setting scheme for noninvasive detection and segmentation of bladder tumor surface in T(1)-weighted magnetic resonance (MR) images. The inner border the wall is first covered by a group ball-shaped detecting windows with different radii. By extracting candidate excluding false positive (FP) candidates, entire detected segmented remaining windows. Different from previous methods that are mostly focusing on existence tumor, this emphasizes segmenting...
Medulloblastoma is the most common malignant brain tumor in children. Despite remarkable advances over previous decades, long‑term survival of patients with medulloblastoma remains poor due to frequent metastatic nature this malignancy. The aim present study was examine role tripartite motif containing 59 (TRIM59) cell metastasis medulloblastoma. It initially demonstrated that TRIM59 expression significantly increased clinical tissues compared adjacent non‑cancerous and differentially...
This paper proposes a framework for detecting the suspected abnormal region of bladder wall via magnetic resonance (MR) cystography. Volume-based features are used. First, is divided into several layers, based on which path from each voxel inner border to outer found. By using length measure thickness and bent rate (BR) term geometry property voxels border, seed representing abnormalities determined. Then, by tracing seed, weighted BR constructed determine voxels, inside wall. All grouped...
Colorectal cancer (CRC) is a significant global health issue, and lymph node metastasis (LNM) crucial prognostic factor. Accurate prediction of LNM essential for developing individualized treatment strategies patients with CRC. However, the challenging depends on various factors such as tumor histology, clinicopathological features, molecular characteristics. The most reliable method to detect histopathological examination surgically resected specimens; however, this invasive,...
Lysyl oxidase-like 2 (LOXL2), a member of the lysyl oxidase (LOX) family, is copper-dependent enzyme that catalyzes oxidative deamination lysine residues on protein substrates. LOXL2 was found to be overexpressed in esophageal squamous cell carcinoma (ESCC) our previous research. We later identified splicing variant LOXL2-delta72 and we its wild type counterpart ESCC cells following microarray analyses. First, differentially expressed genes (DEGs) compared empty plasmid were applied generate...
The present study aimed to investigate the mechanisms underlying microRNA (miRNA)‑mediated regulation of chondrogenic differentiation. Mouse embryo‑derived stem cells C3H10T1/2 were cultured and differentiation was induced using transforming growth factor‑β3 (TGF‑β3). In addition, miRNA expression profiles detected via array analysis, quantitative polymerase chain reaction performed verify differentially expressed miRNAs. Furthermore, bioinformatics software used predict putative targets...
LOXL2 (lysyl oxidase-like 2), an enzyme that catalyzes oxidative deamination of lysine residue, is upregulated in esophageal squamous cell carcinoma (ESCC). A splice variant LOXL2-e13 and its wild type were overexpressed ESCC cells followed by microarray analyses. In this study, we explored the potential role molecular mechanism based on known protein-protein interactions (PPIs), following analysis KYSE150 overexpressing a variant, denoted LOXL2-e13, or wild-type counterpart. The...
The aim of this study was to evaluate the efficacy and safety trastuzumab, combined with FLOT regimen, in perioperative treatment resectable HER-2-positive advanced gastric cancer.Overall, 45 patients were divided into two groups; 29 experimental group treated trastuzumab 16 control alone. primary endpoint objective response rate (ORR), secondary endpoints disease (DCR), tumor regression grade (TRG), surgical margin, side effects, overall survival.In groups, ORR 72.4% 43.8% (p=0.226), DCR...
Background Colorectal cancer poses a severe risk to public health and has substantial financial impact. Tumor markers such as CEA, CA125, CA19-9, others, well the fecal occult blood test (FOBT), are frequently utilized for colorectal screening initial diagnosis. However, false-positive results of FOBT, CA19-9 can lead misdiagnosis wrong colorectaloscopy, while their false-negative missed diagnosis delayed treatment. Finding practical, affordable, non-invasive diagnostic techniques is crucial...
<title>Abstract</title> Shock waves are widely used to treat various diseases and garnering further attention for medical applications. Growing evidence suggests that the application of extracorporeal shock (ESV) could substantially inhibit tumor growth. However, therapeutic efficacy ESV in colorectal cancer underlying mechanisms remain elusive. Using cell lines HT29 SW620, we generated xenograft mouse models, examined effect a stepwise increase energy on <italic>In vivo</italic>, 60 mJ...
Robot-assisted minimally invasive surgery becomes more and popular, but the lack of force sensing for surgical robots restricts development this technology. The traditional way to obtain tool-tissue interaction is integrate sensors at end instruments, which not well adopted in practical due high-cost sterilization problems. It necessary explore a sensorless obtaining method. A model-based estimation method proposed paper. We studied structure characteristics cable-driven instrument, built an...
Background: Chemotherapy induced diarrhea (CID) is one of the most serious side -effects during cancer treatment, which can cause severe dehydration and malnutrition, or even death.Most CID patients could recover in a few weeks under sufficient supportive treatment. Case presentation:We presented complicated long -lasting by Tegafur Gimeracil Oteracil Potassium Capsule(S -1), widely used Japan China as an oral fluorouracil medicine.We analyzed process mechanism order to offer experiences for...
Abstract The hypoxic tumor microenvironment promotes both cancer progression and drug resistance.Prolyl hydroxylases are sensor proteins that frequently mutated or heterozygously deleted in breast cancers; however, how prolyl hydroxylation regulates resistance remains poorly understood. Here, we found hypoxia to chemotherapy drugs, specifically through hydroxylation-dependent activation of MAPK signaling. We characterized a pVHL-independent mechanism wherein the hydroxylase EglN1 catalyzed...