A5050924929- Antimicrobial Resistance in Staphylococcus
- Antimicrobial Peptides and Activities
- Antibiotic Resistance in Bacteria
- Bacterial biofilms and quorum sensing
- Soft Robotics and Applications
- Microbial Natural Products and Biosynthesis
- Pregnancy and preeclampsia studies
- Tuberculosis Research and Epidemiology
- Reproductive System and Pregnancy
- Biochemical and Molecular Research
- Bacteriophages and microbial interactions
- Immune Response and Inflammation
- Protein Hydrolysis and Bioactive Peptides
- Gastrointestinal Bleeding Diagnosis and Treatment
- Gestational Diabetes Research and Management
- Plant tissue culture and regeneration
- Spinal Fractures and Fixation Techniques
- Bacterial Identification and Susceptibility Testing
- Microbial Metabolic Engineering and Bioproduction
- Bacterial Genetics and Biotechnology
- Photosynthetic Processes and Mechanisms
- Pneumocystis jirovecii pneumonia detection and treatment
- IoT Networks and Protocols
- Plant biochemistry and biosynthesis
- Plant Virus Research Studies
University of Hong Kong
2016-2025
Tongji Hospital
2020-2025
Huazhong University of Science and Technology
2020-2025
Chinese University of Hong Kong
2016-2024
Technische Universität Berlin
2024
Gansu University of Traditional Chinese Medicine
2024
Northeast Agricultural University
2024
Ministry of Agriculture and Rural Affairs
2024
Hebei University of Engineering
2016-2019
ENN (China)
2019
Drug-resistant superbugs pose a huge threat to human health. Infections by Enterobacteriaceae producing metallo-β-lactamases (MBLs), e.g., New Delhi metallo-β-lactamase 1 (NDM-1) are very difficult treat. Development of effective MBL inhibitors revive the efficacy existing antibiotics is highly desirable. However, such not clinically available till now. Here we show that an anti-Helicobacter pylori drug, colloidal bismuth subcitrate (CBS), and related Bi(III) compounds irreversibly inhibit...
Abstract The rapid emergence of drug resistant Staphylococcus aureus ( S. ) poses a serious threat to public health globally. Silver (Ag)-based antimicrobials are promising combat antibiotic , yet their molecular targets largely elusive. Herein, we separate and identify 38 authentic Ag + -binding proteins in at the whole-cell scale. We then capture snapshot on dynamic action against further validate that could inhibit key target 6-phosphogluconate dehydrogenase through binding catalytic...
We describe an ultra-selective and ultra-sensitive HOCI fluorescent probe <bold>HKOCl-3</bold> for live-cell <italic>in vivo</italic> imaging quantitative applications.
Rheumatoid arthritis (RA) and postmenopausal osteoporosis (PMOP) are common bone-immune diseases. The imbalance between helper (Th17) regulatory T cells (Tregs) produced during differentiation of CD4 + plays a key role in bone remodelling disorders RA PMOP. However, the specific mechanism this PMOP has not been clarified. Identifying underlying Th17/Treg represents factor research development new drugs for immune In review, potential roles Th17, Treg, regulating have summarised, mechanisms...
Significance The dissemination of antibiotic resistance in pathogenic bacteria is remarkable, and antivirulence agents with novel mechanisms action could lead to innovative therapeutic concepts. simultaneous suppression multiple virulence factors or pathways using small-molecule compounds an attractive approach reducing the Staphylococcus aureus may offer promising potential combating multidrug-resistant such as methicillin-resistant S. . Here we describe a conceptual breakthrough applying...
Peroxiredoxin I (Prx I) plays an important role in cancer development and inflammation. It is a dual-functional protein which acts as both antioxidant enzyme molecular chaperone. While there have been intensive studies on its peroxidase activity, Prx I's chaperone activity remains elusive, likely due to the lack of inhibitors. Here we report that natural product triptolide selectively inhibits I, but not activity. Through direct interaction with corresponding cysteines, triggers dissociation...
This study reveals the synergy of hinokitiol and bismuth drugs against antibiotic-resistant bacteria. Their combination enhances antimicrobial efficacy, showing broad-spectrum activity promising potential to combat resistance.
Gestational diabetes mellitus (GDM) refers to hyperglycemia first recognized during pregnancy, characterized by decreased insulin sensitivity and impaired glucose metabolism. Dynamic fusion fission processes within mitochondria play critical roles in maintaining metabolism homeostasis. Given the fundamental role of mitochondrial factor (MFF) fission, intention this study was investigate dynamics placentae GDM patients explore MFF etiopathogenesis progression through modulation resistance. 40...
Staphylococcus aureus, especially methicillin-resistant S. aureus (MRSA), is a life-threatening pathogen in hospital- and community-acquired infections. The golden-colored carotenoid pigment of staphyloxanthin, contributes to the resistance reactive oxygen species (ROS) host neutrophil-based killing. Here, we describe novel inhibitor (NP16) production that reduces survival under oxidative stress conditions. Carotenoid components analysis, enzyme inhibition, crtN mutational studies indicated...
Deep convolutional neural networks have achieved great success on various image recognition tasks. However, it is nontrivial to transfer the existing video due fact that most of them are developed for static image. Frame-byframe processing suboptimal because temporal information vital understanding totally abandoned. Furthermore, frame-by-frame slow and inefficient, which can hinder practical usage. In this paper, we propose LWDN (Locally-Weighted Deformable Neighbors) object detection...
Increased usage of daptomycin to treat infections caused by Gram-positive bacterial pathogens has resulted in emergence resistant mutants. In a search for more effective analogues through medicinal chemistry studies, we found that methylation at the nonproteinogenic amino acid kynurenine could result significant enhancement antibacterial activity. Termed "kynomycin," this new antibiotic exhibits higher activity than and is able eradicate methicillin-resistant Staphylococcus aureus (MRSA)...
To assess whether vancomycin minimum inhibitory concentration (MIC) creeps among clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA) in a regional hospital China. Furthermore, to analyze the causes MIC and relationship between MICs outcome patients with MRSA infection.All from 2006-2010 were retrieved tested by broth microdilution procedure determine their MIC. Meanwhile, related patient records analyzed.While all susceptive vancomycin, percentage = 1 mg/L increased...
Infected macrophages release signaling lipids ( e.g. , linoleic acid) and activate subsequent metabolic pathways to stimulate ROS generation that facilities intracellular bacteria killing, which may represent a novel mechanism of bacterial elimination.
Antibiotics are widely used for the treatment of bacterial infections. However, injudicious use antibiotics based on an empirical method may lead to emergence resistant strains. Despite appropriate administration antibiotics, their concentrations remain subinhibitory in body, due individual variations tissue distribution and metabolism rates. This promote virulence complicate strategies. To investigate whether certain classes will induce worsen infection under vivo conditions. Different were...
Abstract Background Traditional endoscopy may cause tissue trauma and discomfort to patients because of the use relatively long semi‐rigid scopes. Methods A wireless robotic endoscope has been designed based on minimally invasive locomotion techniques for energy, monitoring, telecontrol. Results The can move forward or backward effectively in a smooth synthetic glass tube. increase tube dip angle reduces relative speed. robot moves with lower efficiency viscoelasticity intestinal vitro pig...