A5101933151- MicroRNA in disease regulation
- Thyroid Cancer Diagnosis and Treatment
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Psoriasis: Treatment and Pathogenesis
- Cytokine Signaling Pathways and Interactions
- Immune Cell Function and Interaction
- Gut microbiota and health
- Ferroptosis and cancer prognosis
- Immune Response and Inflammation
- Plant Gene Expression Analysis
- Gastrointestinal motility and disorders
- Epigenetics and DNA Methylation
- Acute Myeloid Leukemia Research
- Angiogenesis and VEGF in Cancer
- Immune cells in cancer
- Pancreatic function and diabetes
- Radiomics and Machine Learning in Medical Imaging
- Invertebrate Immune Response Mechanisms
- Pancreatic and Hepatic Oncology Research
- Circular RNAs in diseases
- Cancer Genomics and Diagnostics
- Helicobacter pylori-related gastroenterology studies
- T-cell and B-cell Immunology
- Liver Disease Diagnosis and Treatment
Heilongjiang University of Chinese Medicine
2023-2025
Zhejiang University
2018-2025
Tarim University
2025
National Clinical Research Center for Digestive Diseases
2025
Air Force Medical University
2025
Xijing Hospital
2025
Huazhong University of Science and Technology
2025
Tongji Hospital
2025
Sichuan University
2024
Yale University
2010-2024
Secondary bacterial pneumonia leads to increased morbidity and mortality from influenza virus infections. What causes this susceptibility, however, is not well defined. Host defense infection relies only on immune resistance mechanisms but also the ability tolerate a given level of pathogen burden. Failure either or tolerance can contribute disease severity, making it hard distinguish their relative contribution. We employ coinfection mouse model Legionella pneumophila in which we separate...
CXC chemokine receptor 3 (CXCR3) is the for IFN-γ–inducible C-X-C chemokines MIG/CXCL9, IP-10/CXCL10, and I-TAC/CXCL11. CXCR3 expressed on activated immune cells proliferating endothelial cells. The role of in fibroproliferation has not been investigated. We examined pulmonary injury repair vivo. CXCR3-deficient mice demonstrated increased mortality with progressive interstitial fibrosis relative to WT mice. Increased occurred without inflammatory cell recruitment. deficiency resulted both a...
There are no known effective and reliable biomarkers to distinguish benign thyroid nodules from papillary carcinomas (PTC). Previous studies have indicated that serum microRNA (miRNA) profiles may be diagnostic and/or prognostic markers for numerous other cancers.We studied circulating miRNA in patients with PTC or healthy controls identify useful as PTC.Genome-wide expression were determined using Solexa sequencing followed by extensive quantitative RT-PCR validation 245 subjects (106 PTC,...
Pulmonary fibrosis is a progressive, dysregulated response to injury culminating in compromised lung function due excess extracellular matrix production. The heparan sulfate proteoglycan syndecan-4 important mediating fibroblast-matrix interactions, but its role pulmonary has not been explored. To investigate this issue, we used intratracheal instillation of bleomycin as model acute and fibrosis. We found that treatment increased expression. Moreover, observed marked decrease neutrophil...
As a newly identified type of programmed cell death, cuproptosis may have an impact on cancer development, including clear renal carcinoma (ccRCC). Herein, we first noticed that the expression levels regulators exhibited tight correlation with clinicopathological characteristics ccRCC. The cuproptosis-sensitive sub-type (CSS), classified via consensus clustering analysis, harbored higher overall survival rate compared to cuproptosis-resistant (CRS), which resulted from differential...
Abstract Background The faithful maintenance of DNA methylation homeostasis indispensably requires methyltransferase 1 (DNMT1) in cancer progression. We previously identified DNMT1 as a potential candidate target for oral squamous cell carcinoma (OSCC). However, how the DNMT1- associated global is exploited to regulate OSCC remains unclear. Methods shRNA-specific knockdown was employed on cells vitro, use inhibitors. A xenografted mouse model established determine effect tumor suppression....
Degradative fragments of cartilage oligomeric matrix protein (COMP) have been observed in arthritic patients. The physiological enzyme(s) that degrade COMP, however, remain unknown. We performed a yeast two-hybrid screen (Y2H) to search for proteins associate with COMP identify an interaction partner might it. One using the epidermal growth factor (EGF) domain as bait led discovery ADAMTS-7. Rat ADAMTS-7 is composed 1595 amino acids, and this exhibits higher expression musculoskeletal...
Abstract CD44 is a transmembrane adhesion molecule and hemopoietic has an essential role in hyaluronan clearance resolution of noninfectious lung injury. In this study, we examined the acute pulmonary inflammation regulation LPS-TLR signaling. Following intratracheally LPS treatment, CD44−/− mice demonstrated exaggerated inflammatory response characterized by increased cell recruitment, elevated chemokine expression bronchoalveolar lavage fluid, marked increase NF-κB DNA-binding activity...
Abstract Fragaria nilgerrensis is a wild diploid strawberry species endemic to east and southeast region in Asia provides rich source of genetic variations for improvement. Here, we present chromosome‐scale assembly F. using single‐molecule real‐time (SMRT) Pacific Biosciences sequencing chromosome conformation capture (Hi‐C) genome scaffolding. The size was 270.3 Mb, with contig N50 ∼8.5 Mb. A total 28 780 genes 117.2 Mb transposable elements were annotated this genome. Next, detailed...
MicroRNAs (miRNAs) are endogenous, small, non-coding RNAs that play important roles in multiple biological processes. MiR-20b has been reported to be dysregulated papillary thyroid carcinoma (PTC). However, the functional still largely unknown. This study aimed investigate functions and underlying molecular mechanisms of miR-20b PTC.The expression was assessed by quantitative reverse transcription polymerase chain reaction 47 pairs PTC adjacent normal tissues. The association between...
Secondary hemophagocytic lymphohistiocytosis (sHLH) is a highly mortal complication associated with sepsis. In adults, it often seen in the setting of infections, especially viral but mechanisms that underlie pathogenesis are unknown. sHLH characterized by hyperinflammatory state and presence hemophagocytosis. We found sequential challenging mice nonlethal dose toll-like receptor (TLR) agonist followed TLR4 agonist, not other permutations, produced lethal recapitulates many aspects human...
Diabetic retinopathy (DR) is a serious microvascular complication of diabetes. This study demonstrates the antiangiogenic effects scutellarin (SCU) on high glucose- and hypoxia-stimulated human retinal endothelial cells (HRECs) diabetic rat model by oral administration. The mechanisms SCU in vitro vivo were investigated. HRECs cultured (30 mM D-glucose) hypoxia (cobalt chloride-treated)-stimulated condition to evaluate CCK-8 test, cell migration experiment (wound healing transwell), tube...
Loss of articular cartilage because extracellular matrix breakdown is the hallmark arthritis. Degradative fragments oligomeric protein (COMP), a prominent noncollagenous component in cartilage, have been observed synovial fluid, and serum arthritis patients. The molecular mechanism COMP degradation enzyme(s) responsible for it, however, remain largely unknown. ADAMTS-12 (a disintegrin metalloprotease with thrombospondin motifs) was shown to associate both <i>in vitro</i> vivo</i>....