A5030974394- Pancreatic function and diabetes
- Metabolism, Diabetes, and Cancer
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Adipose Tissue and Metabolism
- Neuroendocrine Tumor Research Advances
- Cancer, Hypoxia, and Metabolism
- Cancer Mechanisms and Therapy
- RNA modifications and cancer
- Diabetes Treatment and Management
- Mitochondrial Function and Pathology
- Erythrocyte Function and Pathophysiology
- Circular RNAs in diseases
- Diabetes and associated disorders
- Neonatal Respiratory Health Research
- Gestational Diabetes Research and Management
- Pregnancy and preeclampsia studies
- Pancreatic and Hepatic Oncology Research
- Lung Cancer Treatments and Mutations
- Pluripotent Stem Cells Research
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Lung Cancer Diagnosis and Treatment
- Cardiac Fibrosis and Remodeling
- 3D Printing in Biomedical Research
- Cystic Fibrosis Research Advances
Shandong Provincial QianFoShan Hospital
2025
Shandong First Medical University
2025
Jining Medical University
2025
Yichang Central People's Hospital
2025
First Hospital of Shijiazhuang
2015-2023
Yale University
2002-2020
University of Minnesota
2016
Peking University
2013
Second Hospital of Tianjin Medical University
2008
Tianjin Medical University
2008
Background: Long noncoding RNAs (lncRNAs) are a new class of cancer regulators. Here, we aimed to investigate the diagnostic and therapeutic values an lncRNA, differentiation antagonizing RNA (DANCR), in lung cancer. Methods: Real-time polymerase chain reaction was used compare DANCR levels normal cancerous tissues as well cells. Lentiviral transduction induce overexpression or silencing vitro, followed by monitoring cell proliferation, colony formation, changes microRNA-216a (miR-216a)...
Non–small cell lung cancer accounts for 85% of all types and is the leading cause worldwide cancer-associated mortalities. MiR-124 epigenetically silenced in various plays important roles tumor development progression. was also significantly downregulated non–small patients. Glycolysis has been considered as a feature cells; hypoxia-inducible factor 1-alpha/beta Akt are key enzymes regulation glycolysis energy metabolism cells. However, role miR-124 proliferation, glycolysis, remains...
Abstract CD44 is a transmembrane adhesion molecule and hemopoietic has an essential role in hyaluronan clearance resolution of noninfectious lung injury. In this study, we examined the acute pulmonary inflammation regulation LPS-TLR signaling. Following intratracheally LPS treatment, CD44−/− mice demonstrated exaggerated inflammatory response characterized by increased cell recruitment, elevated chemokine expression bronchoalveolar lavage fluid, marked increase NF-κB DNA-binding activity...
Highlights•Enhanced mitochondrial GTP (mtGTP) production amplifies insulin secretion•mtGTP regulates PEPCK-M and cytosolic Ca2+, not OxPhos, to trigger secretion•Exuberant secretion enhanced biosynthesis can coexist without toxicity•mtGTP turnover enhances content, granule docking, massSummaryMechanisms coordinating pancreatic β cell metabolism with are essential for glucose homeostasis. One key mechanism of nutrient sensing uses the cycle. In this cycle, mtGTP synthesized by succinyl-CoA...
Lung cancer, especially non-small cell lung cancer (NSCLC), is the major cause of death worldwide. Mutations in epidermal growth factor receptor <i>(EGFR)</i> and hepatocyte <i>(c-Met)</i>, both which are tyrosine kinases, have been identified a considerable percentage NSCLC patients. EGFR c-Met share same downstream pathways cooperate not only promoting metastasis but also conferring resistance to kinase inhibitor (TKI) therapies NSCLC. MicroRNAs (miRNAs) family...
Significance The CDC projects that by the year 2050 one in three adults will be affected diabetes United States alone. A key feature of type 2 is insulin resistance, which associated with ectopic lipid deposition tissues such as liver. We have discovered a novel regulatory mechanism liver linking protein catabolism and ureagenesis to increased oxidation. By increasing urea production, flux through enzyme argininosuccinate synthetase enhanced, leading activation AMP-activated kinase hepatic...
Aims/Background Gestational diabetes mellitus (GDM) is a common complication during pregnancy. This retrospective study investigates the correlation between umbilical blood flow index and maternal-fetal outcomes in pregnant women with GDM, aiming to contribute evidence-based risk assessment management strategy this high-risk obstetric population. Methods recruited 119 GDM who were admitted Yichang Central People’s Hospital, January 2022 2024. Based on index, participants divided into normal...
Oesophageal cancer (OC) is one of the most fatal malignancies in world, and chemoresistance restricts therapeutic outcome OC. Long noncoding RNA (lncRNA) was reported to play roles multiple types. Yet, function lncRNA OC has not been reported. A gene, PCAT‐1, showed higher expression tissues, especially secondary compared with normal mucosa tissues. Overexpression PCAT‐1 increased proliferation rate growth cells. Inhibition decreased cells, cisplatin chemosensitivity. In a mouse xenograft...
Lung cancer is one of the most malignant cancers with a high metastatic potential. The purpose this study was to role and underlying mechanism miR-214 in lung progression. expression normal tissue analyzed by quantitative real-time PCR analysis. Furthermore, H1299 cells were infected lentivirus, effect infection on cell viability migration analyzed. Carboxypeptidase-D (CPD), as potential target miR-214, characterized either or tissues. interaction CPD tumor suppressing characterized. We...
Maturity Onset Diabetes of the Young-type 3 (MODY-3) has been linked to mutations in transcription factor hepatic nuclear (HNF)-1alpha, resulting deficiency glucose-stimulated insulin secretion. In INS-1 cells overexpressing doxycycline-inducible HNF-1alpha dominant-negative (DN-) gene mutations, and islets from Hnf-1alpha knock-out mice, secretion was impaired response glucose (15 mm) other nutrient secretagogues. Decreased rates glutamine plus leucine methyl pyruvate, but not potassium...
Mitochondrial GTP (mtGTP)-insensitive mutations in glutamate dehydrogenase (GDH(H454Y)) result fasting and amino acid-induced hypoglycemia hyperinsulinemia hyperammonemia (HI/HA). Surprisingly, may occur this disorder despite appropriately suppressed insulin. To better understand the islet-specific contribution, transgenic mice expressing human activating mutation β-cells (H454Y mice) were characterized vivo. As humans with HI/HA, H454Y had hypoglycemia, but plasma insulin concentrations...
Diabetes mellitus is highly prevalent worldwide. High-fat-diet (HFD) consumption can lead to liver fat accumulation, impair hepatic glycometabolism, and cause insulin resistance the development of diabetes. Resveratrol has been shown improve blood glucose concentration diabetic mice, but its effect on abnormal glycometabolism induced by HFD-feeding mechanism involved are unknown. In this study, we determined effects resveratrol high-fat-diet-fed mice a hepatocyte model measuring serum...