A5056270439- Pancreatic function and diabetes
- Pancreatic and Hepatic Oncology Research
- Neuroendocrine Tumor Research Advances
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Prenatal Screening and Diagnostics
- Cancer Genomics and Diagnostics
- Cancer, Stress, Anesthesia, and Immune Response
- Oxidative Organic Chemistry Reactions
- Neuropeptides and Animal Physiology
- Electrocatalysts for Energy Conversion
- Bioactive Compounds and Antitumor Agents
- Ammonia Synthesis and Nitrogen Reduction
- Chemical Synthesis and Analysis
- CO2 Reduction Techniques and Catalysts
- Synthesis and Reactions of Organic Compounds
- Acute Lymphoblastic Leukemia research
- Chronic Lymphocytic Leukemia Research
- Organic Chemistry Cycloaddition Reactions
- Asymmetric Synthesis and Catalysis
- Biochemical and Molecular Research
Yale University
2019-2022
University of New Haven
2022
Hofstra University
2017-2020
Yale Cancer Center
2019-2020
Hemel Hempstead Hospital
2017
A copper catalyst is active towards water reduction with distinctive pH-dependent mechanisms. The Cu<sup>III</sup>–H<sup>−</sup> intermediate bypassed by PCET processes.
The effect of solvents on the 1,3-dipolar cyclization reaction between ethyl propiolate and 2-furfuryl nitrile oxide was studied in various organic solvents. As expected, major product ethyl-3-(2-furanyl)-5-carboxylate. relative ratio 3,5- to 3,4- disubstituted isoxazoles dichloromethane, toluene, ethanol dimethyl sulfoxide were 3.4, 2.0, 1.9 1.5 respectively. Experimental regioselectivity found be dissimilar density functional theory predictions.
SUMMARY Obesity is a major modifiable risk factor for pancreatic ductal adenocarcinoma (PDAC), yet how and when obesity contributes to PDAC progression not well understood. Leveraging an autochthonous mouse model, we demonstrate causal reversible role in early progression, showing that markedly enhances tumorigenesis, while genetic or dietary induction of weight loss intercepts cancer development. Bulk single cell molecular analyses human murine samples define microenvironmental consequences...
Abstract Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer-related death in United States. Various epidemiologic studies have shown that obesity increases risk PDAC. With rising rates worldwide, it imperative we understand mechanisms by which promotes PDAC progression. Therefore, to study effect on PDAC, combined a well-established genetic model (Lepob/ob) with faithful oncogenic Kras-driven pancreatic cancer (KC: Pdx1-Cre; KrasLSL-G12D/+) and showed obese mice had...
The 1,3-dipolar cycloaddition reaction of dimethyl 2-methyleneglutarate and (-)-menthone-derived nitrone occurred with moderate selectively to produce the desired isoxazolidine which was a direct precursor (2S,4S)-substituted glutamate derivative in an overall yield 20%.The possibility preparing unnatural amino acid, (S)-(+)-lycoperdic acid studied based on its evidence within mass spectra final product.1,3-Dipolar (1) alkene (2) is general method for 3,5-and 3,4-isoxazolidines (3 4,...
Abstract KRAS is a proto-oncogene found mutated in &gt;90% of pancreatic ductal adenocarcinomas (PDAC) and encodes for GTPase that mediates signaling transduction through the mitogen-activated protein kinase (MAPK) PI3K/AKT pathways. Mutations amino acids G12, G13, Q61 prevent its inactivation by regulatory GTPase-activating proteins (GAPs), resulting constitutive activation. Previous work indicates mutants possess unique biochemical differences could result divergent allele-specific...
Abstract Obesity is a major modifiable host risk factor for pancreatic ductal adenocarcinoma (PDAC), the third leading cause of cancer death in United States and morbidity mortality worldwide. Despite rapid rise prevalence obesity, surprisingly little known about how it drives tumor progression. Therefore, deciphering these mechanisms not only societal imperative but also represents key untapped target to develop novel strategies PDAC prevention therapy. Motivated by this gap knowledge, we...