A5048058078- Adipose Tissue and Metabolism
- Liver Disease Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
- Pancreatic function and diabetes
- Mitochondrial Function and Pathology
- Diet and metabolism studies
- Adipokines, Inflammation, and Metabolic Diseases
- Diet, Metabolism, and Disease
- Neuroscience and Neuropharmacology Research
- Probiotics and Fermented Foods
- Aquaculture disease management and microbiota
- Viral gastroenteritis research and epidemiology
- Neurological Disease Mechanisms and Treatments
- Gut microbiota and health
- Effects and risks of endocrine disrupting chemicals
- Toxic Organic Pollutants Impact
- Mycobacterium research and diagnosis
- Cardiac Ischemia and Reperfusion
- Lipid metabolism and biosynthesis
- Parasitic Infections and Diagnostics
- Salmonella and Campylobacter epidemiology
- Listeria monocytogenes in Food Safety
- Neuroinflammation and Neurodegeneration Mechanisms
- Microbial infections and disease research
- Advanced Biosensing Techniques and Applications
Gachon University
2008-2025
Seoul National University
1997-2019
Kangwon National University
2004-2017
Government of the Republic of Korea
2017
Kangwon National University Hospital
2016
Park University
2016
Institute of Molecular Medicine
2016
Yale University
2009-2015
Seowon University
2015
Howard Hughes Medical Institute
2010-2014
The H19 lncRNA has been implicated in development and growth control is associated with human genetic disorders cancer. Acting as a molecular sponge, inhibits microRNA (miRNA) let-7. Here we report that significantly decreased muscle of subjects type-2 diabetes insulin resistant rodents. This decrease leads to increased bioavailability let-7, causing diminished expression let-7 targets, which recapitulated vitro where depletion results impaired signaling glucose uptake. Furthermore, acute...
Peroxisome proliferator-activated receptor-γ coactivator (PGC)-1α has been shown to play critical roles in regulating mitochondria biogenesis, respiration, and muscle oxidative phenotype. Furthermore, reductions the expression of PGC-1α have implicated pathogenesis type 2 diabetes. To determine effect increased muscle-specific on mitochondrial function glucose lipid metabolism vivo, we examined body composition, energy balance, liver insulin sensitivity by hyperinsulinemic-euglycemic clamp...
Resistin belongs to a family of cysteine-rich secreted polypeptides that are mainly produced by monocytes/macrophages in humans. Recently, high concentrations resistin were shown induce vascular endothelial dysfunction and smooth muscle cell proliferation. We examined if was from macrophages locally atheromas it affected function human.Immunohistochemical staining human vessels showed aortic aneurysms exhibited resistin-positive areas along macrophage infiltration, while normal arteries...
OBJECTIVE Inhibition of the Na+-glucose cotransporter type 2 (SGLT2) is currently being pursued as an insulin-independent treatment for diabetes; however, behavioral and metabolic consequences SGLT2 deletion are unknown. Here, we used a knockout mouse to investigate effect increased renal glucose excretion on homeostasis, insulin sensitivity, pancreatic β-cell function. RESEARCH DESIGN AND METHODS mice were fed regular chow or high-fat diet (HFD) 4 weeks, backcrossed onto db/db background....
Low-carbohydrate, high-fat ketogenic diets (KD) have been suggested to be more effective in promoting weight loss than conventional caloric restriction, whereas their effect on hepatic glucose and lipid metabolism the mechanisms by which they may promote remain controversial. The aim of this study was explore role KD liver muscle insulin sensitivity, metabolism, energy expenditure, food intake. Using hyperinsulinemic-euglycemic clamps, we studied action mice fed a or regular chow (RC). Body...
Estrogen replacement therapy reduces the incidence of type 2 diabetes in postmenopausal women; however, mechanism is unknown. Therefore, aim this study was to evaluate metabolic effects estrogen an experimental model menopause. At 8 weeks age, female mice were ovariectomized (OVX) or sham (SHAM) operated, and OVX treated with vehicle estradiol (E2) (OVX+E2). After 4 high-fat diet feeding, had increased body weight fat mass compared SHAM OVX+E2 mice. displayed reduced whole-body energy...
Mice overexpressing acylCoA:diacylglycerol (DAG) acyltransferase 2 in the liver (Liv- DGAT2 ) have been shown to normal hepatic insulin responsiveness despite severe steatosis and increased triglyceride, diacylglycerol, ceramide content, demonstrating a dissociation between resistance. This led us reevaluate role of DAG causing resistance this mouse model steatosis. Using hyperinsulinemic-euglycemic clamps, we studied action Liv- mice their wild-type (WT) littermate controls. Here, show that...
The DNA sequences of wheat Acc-1 and Acc-2 loci, encoding the plastid cytosolic forms enzyme acetyl-CoA carboxylase, were analyzed with a view to understanding evolution these genes origin three genomes in modern hexaploid wheat. loci from each wheats Triticum urartu (A genome), Aegilops tauschii (D turgidum (AB aestivum (ABD as well two Acc-2-related pseudogenes T. sequenced. 2.3-2.4 Mya divergence time calculated here for homoeologous chromosomes, on basis coding intron genes, is at low...
OBJECTIVE Thioredoxin interacting protein (Txnip), a regulator of cellular oxidative stress, is induced by hyperglycemia and inhibits glucose uptake into fat muscle, suggesting role for Txnip in type 2 diabetes pathogenesis. Here, we tested the hypothesis that Txnip-null (knockout) mice are protected from insulin resistance high-fat diet. RESEARCH DESIGN AND METHODS gene-deleted age-matched wild-type littermate control were maintained on standard chow diet or subjected to 4 weeks feeding....
Nonalcoholic fatty liver disease (NAFLD) and insulin resistance have recently been found to be associated with increased plasma concentrations of apolipoprotein CIII (APOC3) in humans carrying single nucleotide polymorphisms within the response element APOC3 gene. To examine whether expression would predispose mice NAFLD hepatic resistance, human overexpressing (ApoC3Tg) were metabolically phenotyped following either a regular chow or high-fat diet (HFD). After HFD feeding, ApoC3Tg had...
The endoplasmic reticulum (ER) is the principal organelle in cell for protein folding and trafficking, lipid synthesis, cellular calcium homeostasis. Perturbation of ER function results activation unfolded response (UPR) implicated abnormal biosynthesis development insulin resistance. In this study, we investigated whether transcription sphingosine kinase (Sphk)2 regulated by stress-mediated UPR pathways. Sphk2, a major isotype liver, was transcriptionally up-regulated tunicamycin...
The gut microbiome has been known to contribute up ~30% of the energy absorption host. Although various beneficial mechanisms probiotics have suggested for non-alcoholic fatty liver disease (NAFLD), whether and which impact host's intestinal not yet quantitatively studied. Here, we suggest a novel mechanism against NAFLD, in Lactobacillus rhamnosus GG, most common probiotic, shares acids prevents development diet-induced hepatic steatosis. By using quantitative methods (radioactive tracers...
Severe acute respiratory syndrome (SARS) is a life-threatening disease for which accurate diagnosis essential. Although many tools have been developed the of SARS, false-positive reactions in negative sera may occur because cross-reactivity with other coronaviruses. We raised polyclonal and monoclonal antibodies (Abs) using recombinant form SARS virus nucleocapsid protein. Cross-reactivity these anti-SARS Abs against human coronavirus (HCoV) 229E HCoV OC43 were determined by Western...
Invariant natural killer T cells (iNKTs) are innate-like that highly concentrated in the liver and recognize lipids presented on MHC-like molecule CD1d. Although capable of a myriad responses, few essential functions have been described for iNKTs. Among many cell types immune system implicated metabolic control disease, iNKTs seem ideally poised such role, yet little has done to elucidate possible function. We hypothesized lipid presentation by CD1d could report status engage regulate...