To observe the antiobesity activity of trans-10,cis-12-conjugated linoleic acid (CLA)-producing lactobacillus in mice.Lactobacillus plantarum PL62, which can grow presence acid, was selected and studied. The culture supernatant Lact. PL62 contained (6.4 microg ml(-1)), crude enzyme prepared from washed cells produced trans-10,cis-12 CLA (1395 mg(-1) protein). reduced weights epididymal, inguinal, mesenteric, perirenal white adipose tissues significantly blood levels total glucose body mice...

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTConstrictive and intrinsic binding in a hemicarcerand containing four portalsDonald J. Cram, Michael T. Blanda, Kyungsoo Paek, Carolyn B. KnoblerCite this: Am. Chem. Soc. 1992, 114, 20, 7765–7773Publication Date (Print):September 1, 1992Publication History Published online1 May 2002Published inissue 1 September 1992https://pubs.acs.org/doi/10.1021/ja00046a023https://doi.org/10.1021/ja00046a023research-articleACS PublicationsRequest reuse...

The syntheses are reported of ten new carceplexes, hemicarceplexes, or their free hosts by coupling different similar pairs cavitands at rims with four O(CH2)nO m-(OCH2)2C6H4 bridging groups. Different combinations seven and five groups were involved in the shell closures, whose yields ranged from 50 to 1.8%. Seven have like northern southern hemispheres, whereas three possess differently shaped hemispheres. yield patterns interpreted terms complexing guest preorganizing reaction partners...

Bisvelcrand 3 based on resorcin[4]arene was obtained by a stepwise route, and the formation of oligobisvelcraplex 3n solvophobic π−π stacking interaction observed. 1H NMR spectroscopic studies revealed that ΔG⧧pseudorotation is 16.7 kcal mol-1 in C6D5NO2 solution. The pulsed field gradient spin−echo (PGSE) experiment VPO showed number aggregation (n) ranges from 7 to 10 CHCl3 solution at 298 K. In high concentration, bisvelcrand tends form gels or fiber.

An unusually stable molecular capsule was formed by heating phenyleneurea-spanned resorcinarene cavitand with 4-methyl-N-p-tolylbenzamide. The behaved as a discrete entity showing cylindrical D(4d) structure and showed no guest exchange in toluene-d(8) even at 100 degrees C. [structure: see text]

The resorcin[4]arene-based benzoylhydrazide cavitands formed stable molecular capsules in nonpolar solvents by the eight intermolecular N-H...O=C hydrogen bondings, two from each four paired hydrazides, and intramolecular O-H2C-O...H-N bondings on cavitand. stability of these depends encapsulated guest following order: CH3SO3(-) > CH3CO2(-) CH3CH2NH2 x HCl approximately = CH3NH2 (CH3)4N(+) toluene C2D2Cl4.

Visible surface-assisted desorption/ionization mass spectrometry (SALDI-MS) has been investigated for several small macromolecules deposited on the graphite plate using laser radiation at 532 nm where most of are transparent. The surface functioned well as a photon absorbing material and an energy transfer mediator visible light. results show that SALDI is much softer ionization technique than UV-MALDI FAB-MS in our with synthetic macromolecules, PPG, PPGMBE cavitand molecules. For...

Resorcin[4]arene-based tetrakis(N-hydantoinylamido)cavitand 1 forms a stable molecular capsule in the presence of suitable anionic guests such as CH3OSO3– or BF4– C2D2Cl4. Molecular G2@12 is stabilized by eight intermolecular imide N-H···O═C hydrogen bondings, two from each four paired hydantoinyl units, and intramolecular amide N-H···O–CH2-O on cavitands. The formations capsules were confirmed 1H, 2D NOESY, 2D-DOSY NMR.

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHost-guest complexation. 51. Cyanospherands, a new type of salt binderKyungsoo Paek, Carolyn B. Knobler, Emily F. Maverick, and Donald J. CramCite this: Am. Chem. Soc. 1989, 111, 23, 8662–8671Publication Date (Print):November 1, 1989Publication History Published online1 May 2002Published inissue 1 November 1989https://pubs.acs.org/doi/10.1021/ja00205a016https://doi.org/10.1021/ja00205a016research-articleACS PublicationsRequest reuse...

The conformations and properties of cavitand 5 with four benzimidazole flaps are studied by (1)H NMR. can form very stable vase structures an enforced concave cavity intermolecular hydrogen bonding hydroxyl-containing molecules, X-OH, such as methanol (X = Me), acetic acid CH(3)CO), trifluoroacetic CF(3)CO). stronger bond donor strengths X-OH are, the bonds formed between NH N atoms neighboring fragments more 5.4HOX stable. annular tautomerism in CDCl(3)/CD(3)OD (9:1, v/v) due to proton...

Double take: Paired carceroisomers of a resorcin[4]arene-based C4v carceplex with an included DMF molecule are formed when non-interacting second guest (CH3CN) exists in excess. The two most stable the each and CH3CH (see picture) were observed 2:1 ratio at 25 °C CDCl3 by 1H NMR spectroscopy, their spatial arrangements studied 1H-1H ROESY experiments. Supporting information for this article is available on WWW under http://www.wiley-vch.de/contents/jc_2002/2006/z503441_s.pdf or from author....

[structure: see text] Three new C(2v) cavitands based on resorcin[4]arene bind water specifically at low temperature in CD(2)Cl(2) or CDCl(3) due to their complementarity as well the solvophobic interaction. The averaged DeltaH(o) and DeltaS(o) values are -2.3 kcal mol(-1) -128 cal K(-1), which gave -DeltaG(o) of 1.9 -50 degrees C saturated CD(2)Cl(2).

The facile synthesis of a resorcin[4]arene-based imino-cavitand with benzamido moieties and its self-assembly into molecular capsules are reported. Benzamido-iminocavitand 2 efficiently self-assembled thermally inert in the presence suitable guests via eight intermolecular N–H⋯OC hydrogen bonds.

Figure S1. Schematic description on the reversible formation of various piperazine derivatives in aqueous solution.S1 The double arrows involve CO2 addition or removal, and single do proton transfers. S2. Crystallization setups for PZ carbamate. N2 respectively filled a balloon was introduced to reaction media contained sealed vial. When with N2, larger crystals could be obtained. S3. FT-IR spectra (a) (b) PZ-dicarbamate salt. S4. PXRD patterns S5. TGA curves measured under nitrogen salt an...

New C(4v) tetraoxatetrathiahemicarcerands and their six hemicarceplexes containing DMF, DMA, DMSO, or NMP were synthesized characterized. Their conformations, kinetic properties, carceroisomerism, twistomerism studied by VT, 2D COSY, NOESY, ROESY (1)H NMR experiments. The decomplexation rates of DMF DMA very slow with high activation energy barriers (73 104 kJ mol(-1), respectively) the complexed guests feel more constriction than free liquid state. largest isomerization barrier...

A new deep imidazoquinoxaline cavitand formed static helical alkane inclusion complexes by CH/pi stabilization of alkanes with the enlarged aromatic pi surfaces cavity inside.

A new chromogenic, self-assembled molecular capsule G@2₂is developed by introducing four (<italic>N</italic>,<italic>N</italic>-dimethyl-4-aminophenyl) azobenzyl moieties on the upper rim of a resorcin[4]arene-based amidoimino-cavitand. The tuning conjugation between amido and (<italic>N</italic>,<italic>N</italic>-dimethyl-4-aminophenyl)azobenzyl groups acid–base titration allows naked-eye observation formation.

Nine new salt binders built on resorcin[4]arene or calix[4]arene and having four aromatic sp2 nitrogens as binding ligands were designed characterized. Structurally rigid cavitands based showed much higher affinities toward metal cations compared to those flexible calix[4]arene. In particular, imidazolylcavitand 7 high affinity for alkali (−ΔG° = 7.0–10.9 kcal mol−1) pyrazolylcavitand 8 unusually selectivity silver cations, which are presumably due their different modes, nesting vs....

Host molecules effectively prefer to recognize F− ion rather than H2O through the upper rim, utilizing strong C–H (N–H)⋯F− interactions. The electropositive field space ("electropositive space") at lower rim of host can also act as a good binding site for small anions such F−. electron withdrawing substituent para-position (X) makes C(N)–Ha⋯F− and C(N)–Ha⋯O interactions much enhanced. calculated vibrational frequencies NMR chemical shifts are consistent with experimental trends.