A5056462107- Diabetes Treatment and Management
- Liver Disease Diagnosis and Treatment
- Diabetes Management and Research
- Diet and metabolism studies
- Diet, Metabolism, and Disease
- Adipose Tissue and Metabolism
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes and associated disorders
- Metabolism, Diabetes, and Cancer
- Pancreatic function and diabetes
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Gestational Diabetes Research and Management
- Pharmacology and Obesity Treatment
- Diabetic Foot Ulcer Assessment and Management
- Healthcare Systems and Practices
- Lipid metabolism and disorders
- Diabetes Management and Education
- Lipid metabolism and biosynthesis
- Adipokines, Inflammation, and Metabolic Diseases
- Pancreatitis Pathology and Treatment
- Health, Medicine and Society
- Endoplasmic Reticulum Stress and Disease
- Neurological and metabolic disorders
- Fibroblast Growth Factor Research
- Bariatric Surgery and Outcomes
Hôpital Beau-Séjour
2007-2025
Geneva College
2012-2024
University Hospital of Geneva
2013-2024
University of Geneva
2010-2024
Société Francophone du Diabète
2023
Civil Service
2022
Institution Genevoise de Maintien à Domicile
2021
University of Lausanne
2003-2019
University Hospital of Lausanne
2015-2017
Centre for Human Drug Research
2016
Reduced peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) expression and mitochondrial dysfunction in adipose tissue have been associated with obesity insulin resistance. Whether this association is causally involved the development of resistance or only a consequence condition has not clearly determined. Here we studied effects adipose-specific deficiency PGC-1α on systemic glucose homeostasis. Loss white fat resulted reduced thermogenic genes mice housed at ambient...
Low birth weight is associated with increased rates of obesity, insulin resistance and type 2 diabetes, but the precise mechanisms for this association remain unclear. We aimed to assess relationships between markers glucose homeostasis or obesity in adults. Cross-sectional population-based study on 1458 women 1088 men aged 35–75 years living Lausanne, Switzerland. Birth was self-reported categorized into ≤2.5, 2.6–3.5, 3.6–4.0 >4.0 kg. Body composition assessed by bioimpedance. Leptin...
Fibroblast growth factor 21 (FGF21) is a potent regulator of glucose and lipid metabolism currently being pursued as therapeutic agent for insulin resistance type 2 diabetes. However, the cellular mechanisms by which FGF21 modifies action in vivo are unclear. To address this question, we assessed regular chow– high-fat diet (HFD)–fed wild-type mice chronically infused with or vehicle. Here, show that administration results improvements both hepatic peripheral sensitivity HFD-fed mice. This...
OBJECTIVE Inhibition of the Na+-glucose cotransporter type 2 (SGLT2) is currently being pursued as an insulin-independent treatment for diabetes; however, behavioral and metabolic consequences SGLT2 deletion are unknown. Here, we used a knockout mouse to investigate effect increased renal glucose excretion on homeostasis, insulin sensitivity, pancreatic β-cell function. RESEARCH DESIGN AND METHODS mice were fed regular chow or high-fat diet (HFD) 4 weeks, backcrossed onto db/db background....
Low-carbohydrate, high-fat ketogenic diets (KD) have been suggested to be more effective in promoting weight loss than conventional caloric restriction, whereas their effect on hepatic glucose and lipid metabolism the mechanisms by which they may promote remain controversial. The aim of this study was explore role KD liver muscle insulin sensitivity, metabolism, energy expenditure, food intake. Using hyperinsulinemic-euglycemic clamps, we studied action mice fed a or regular chow (RC). Body...
Estrogen replacement therapy reduces the incidence of type 2 diabetes in postmenopausal women; however, mechanism is unknown. Therefore, aim this study was to evaluate metabolic effects estrogen an experimental model menopause. At 8 weeks age, female mice were ovariectomized (OVX) or sham (SHAM) operated, and OVX treated with vehicle estradiol (E2) (OVX+E2). After 4 high-fat diet feeding, had increased body weight fat mass compared SHAM OVX+E2 mice. displayed reduced whole-body energy...
Mice overexpressing acylCoA:diacylglycerol (DAG) acyltransferase 2 in the liver (Liv- DGAT2 ) have been shown to normal hepatic insulin responsiveness despite severe steatosis and increased triglyceride, diacylglycerol, ceramide content, demonstrating a dissociation between resistance. This led us reevaluate role of DAG causing resistance this mouse model steatosis. Using hyperinsulinemic-euglycemic clamps, we studied action Liv- mice their wild-type (WT) littermate controls. Here, show that...
Comparative gene identification 58 (CGI-58) is a lipid droplet-associated protein that promotes the hydrolysis of triglyceride by activating adipose lipase. Loss-of-function mutations in CGI-58 humans lead to Chanarin–Dorfman syndrome, condition which accumulates various tissues, including skin, liver, muscle, and intestines. Therefore, without adequate expression, lipids are stored rather than used for fuel, signaling intermediates, membrane biosynthesis. knockdown mice using antisense...
Nonalcoholic fatty liver disease (NAFLD) and insulin resistance have recently been found to be associated with increased plasma concentrations of apolipoprotein CIII (APOC3) in humans carrying single nucleotide polymorphisms within the response element APOC3 gene. To examine whether expression would predispose mice NAFLD hepatic resistance, human overexpressing (ApoC3Tg) were metabolically phenotyped following either a regular chow or high-fat diet (HFD). After HFD feeding, ApoC3Tg had...
Nonalcoholic fatty liver disease (NAFLD) is the most common hepatic disorder related to type 2 diabetes (T2D). The can evolve toward nonalcoholic steatohepatitis (NASH), a state of inflammation and fibrosis. There presently no drug that effectively improves and/or prevents NAFLD/NASH/fibrosis. GLP-1 receptor agonists (GLP-1Ra) are effective in treating T2D. As with endogenous gut incretins, GLP-1Ra potentiate glucose-induced insulin secretion. In addition, limit food intake weight gain,...
In patients with diabetic foot osteomyelitis (DFO) who underwent surgical debridement, we investigated whether a short (3 weeks) duration compared long (6 of systemic antibiotic treatment is associated noninferior results for clinical remission and adverse events (AEs).In this prospective, randomized, noninferiority pilot trial, randomized (allocation 1:1) DFO after debridement to either 3-week or 6-week course therapy. The minimal follow-up the end therapy was 2 months. We outcomes using...