Murielle Bochud
A5072307317- Sodium Intake and Health
- Nutritional Studies and Diet
- Genetic Associations and Epidemiology
- Blood Pressure and Hypertension Studies
- Birth, Development, and Health
- Nutrition, Genetics, and Disease
- Hormonal Regulation and Hypertension
- Obesity, Physical Activity, Diet
- Chronic Kidney Disease and Diabetes
- Epigenetics and DNA Methylation
- Renal function and acid-base balance
- Liver Disease Diagnosis and Treatment
- Vitamin D Research Studies
- Diet and metabolism studies
- Childhood Cancer Survivors' Quality of Life
- Adipokines, Inflammation, and Metabolic Diseases
- SARS-CoV-2 and COVID-19 Research
- Coffee research and impacts
- Heart Rate Variability and Autonomic Control
- Gout, Hyperuricemia, Uric Acid
- Electrolyte and hormonal disorders
- Ion Transport and Channel Regulation
- Health, Environment, Cognitive Aging
- Dialysis and Renal Disease Management
- Health disparities and outcomes
University of Lausanne
2016-2025
Centre universitaire de médecine générale et santé publique, Lausanne
2019-2025
Swiss School of Public Health
2021-2024
University of Bern
2013-2023
Alliance for Health Policy and Systems Research
2022
Faculty (United Kingdom)
2022
University of Edinburgh
2022
NHS Lothian
2022
Institute of Social and Preventive Medicine
2012-2021
University Hospital of Lausanne
2011-2021
Abstract Background Cardiovascular diseases and their associated risk factors remain the main cause of mortality in western societies. In order to assess prevalence cardiovascular (CVRFs) Caucasian population Lausanne, Switzerland, we conducted a population-based study (Colaus Study). A secondary aim CoLaus will be determine new genetic determinants with CVRFs. Methods Single-center, cross-sectional including random sample 6,188 extensively phenotyped subjects (3,251 women 2,937 men) aged 35...
Hypertension is a heritable and major contributor to the global burden of disease. The sum rare common genetic variants robustly identified so far explain only 1%–2% population variation in BP hypertension. This suggests existence more undiscovered variants. We conducted genome-wide association study 1,621 hypertensive cases 1,699 controls follow-up validation analyses 19,845 16,541 using an extreme case-control design. locus on chromosome 16 5′ region Uromodulin (UMOD; rs13333226, combined...
Low birth weight is associated with increased rates of obesity, insulin resistance and type 2 diabetes, but the precise mechanisms for this association remain unclear. We aimed to assess relationships between markers glucose homeostasis or obesity in adults. Cross-sectional population-based study on 1458 women 1088 men aged 35–75 years living Lausanne, Switzerland. Birth was self-reported categorized into ≤2.5, 2.6–3.5, 3.6–4.0 >4.0 kg. Body composition assessed by bioimpedance. Leptin...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific antibody responses to the spike (S) protein monomer, S native trimeric form, or nucleocapsid (N) proteins were evaluated in cohorts of individuals with infection (n = 93) and enrolled a postinfection seroprevalence population study 578) Switzerland. Commercial assays specific for S1 N protein, within newly developed Luminex assay using trimer found be equally sensitive detection acute-infection-phase samples....
Differences in health status by socioeconomic position (SEP) tend to be more evident at older ages, suggesting the involvement of a biological mechanism responsive accumulation deleterious exposures across lifespan. DNA methylation (DNAm) has been proposed as biomarker aging that conserves memory endogenous and exogenous stress during life.We examined association education level, an indicator SEP, lifestyle-related variables with four biomarkers age-dependent DNAm dysregulation: total number...
Background The relation of serum uric acid (SUA) with systemic inflammation has been little explored in humans and results have inconsistent. We analyzed the association between SUA circulating levels interleukin-6 (IL-6), interleukin-1β (IL-1β), tumor necrosis factor- α (TNF-α) C-reactive protein (CRP). Methods Findings This cross-sectional population-based study conducted Lausanne, Switzerland, included 6085 participants aged 35 to 75 years. was measured using uricase-PAP method. Plasma...
The aim of this study was to analyze the associations plasma aldosterone and renin activity with metabolic syndrome each its components. We analyzed data from a family based in Seychelles made up 356 participants (160 men 196 women) 69 families African descent. In multivariable models, associated positively (P < 0.05) blood pressure older individuals (interaction age, P waist circumference sex, negatively high-density lipoprotein cholesterol, particular elevated urinary potassium excretion...
Approximately 3% of the world population is chronically infected with hepatitis C virus (HCV), potential development cirrhosis and hepatocellular carcinoma. Despite availability new antiviral agents, treatment remains suboptimal. Genome-wide association studies (GWAS) identified rs12979860, a polymorphism nearby IL28B, as an important predictor HCV clearance. We report identification novel TT/-G in CpG region upstream which better clearance than rs12979860. By using peripheral blood...
Family studies suggest a genetic component to the etiology of chronic kidney disease (CKD) and end stage renal (ESRD). Previously, we identified 16 loci for eGFR in genome-wide association studies, but associations these single nucleotide polymorphisms (SNPs) incident CKD or ESRD are unknown. We thus investigated with 26,308 individuals European ancestry free at baseline drawn from eight population-based cohorts followed median 7.2 years (including 2,122 cases defined as <60ml/min/1.73m2...