Although Fc receptors (FcRs) for switched immunoglobulin (Ig) isotypes have been extensively characterized, FcR IgM (FcμR) has defied identification. By retroviral expression and functional cloning, we identified a complementary DNA (cDNA) encoding bona fide FcμR in human B-lineage cDNA libraries. is defined as transmembrane sialoglycoprotein of ∼60 kD, which contains an extracellular Ig-like domain homologous to two other IgM-binding (polymeric Ig receptor Fcα/μR) but exhibits exclusive...

The gut microbiome has been known to contribute up ~30% of the energy absorption host. Although various beneficial mechanisms probiotics have suggested for non-alcoholic fatty liver disease (NAFLD), whether and which impact host's intestinal not yet quantitatively studied. Here, we suggest a novel mechanism against NAFLD, in Lactobacillus rhamnosus GG, most common probiotic, shares acids prevents development diet-induced hepatic steatosis. By using quantitative methods (radioactive tracers...

In this study, we propose a method for automatically predicting atrial fibrillation (AF) based on convolutional neural network (CNN) using short-term normal electrocardiogram (ECG) signal.We designed CNN model and optimized it by dropout normalization. One-dimensional convolution, max-pooling, fully-connected multiple perceptron were used to analyze the ECG. The ECG signal was preprocessed segmented train evaluate proposed model. training test sets consisted of two AF one dataset from...

The potential of the paired Ig-like receptors activating (PIR-A) and inhibitory (PIR-B) types for modifying an IgE antibody–mediated allergic response was evaluated in mouse bone marrow–derived mast cells. Although cells produced both PIR-A PIR-B, PIR-B found to be preferentially expressed on cell surface, where it constitutively tyrosine phosphorylated associated with intracellular SHP-1 protein phosphatase. coligation receptor (FcεRI) inhibited IgE-mediated activation release serotonin....

The Fc receptor for IgA and IgM (Fcalpha/muR) is of particular interest because it can bind antibodies both isotypes thus may play a pivotal role in systemic mucosal immunity. Using ligands newly generated Fcalpha/muR specific monoclonal we have defined biochemical features cellular distribution the human Fcalpha/muR. Both recombinant native forms are expressed on cell surface as remarkably stable homodimeric transmembrane glycoproteins that specifically polymeric or IgA. only B cells to...

SUMMARY The humoral and genital secretory immune response to chronic SIV infection was compared between female Rhesus macaques inoculated by i.v. or intravaginal routes. Total IgG levels in serum were 10-fold higher SIV-infected animals when with uninfected controls. Vaginal washes from normal contained predominantly IgA IgG, while those high of IgG. had titres SIV-specific serum, lower but detectable IgM responses. similar intravenously intravaginally animals. anti-SIV the vaginal consisted...

In this study, the accuracy of inputs required for finite element analysis, which is mainly used biomechanical analysis bones, was improved. To ensure a muscle force and joint contact similar to actual values, musculoskelet

Peripheral arterial disease (PAD) is an age-related medical condition affecting mostly muscular arteries of the limb. It 3rd leading cause atherosclerotic morbidity. The mechanical environment endothelial cells (ECs) in PAD characterized by disturbed blood flow (d-flow) and stiff extracellular matrices. In PAD, stiffness due to decreased elastin function increased collagen content. These parameters are largely missing from current models PAD. has been previously proven that ECs exposed...

A microfluidic valvular chip and a numerical model were created to study lymph transport characteristics.

최근 모바일 환경의 발전으로 시간적, 공간적 제약이 없어짐으로서, SNS에서 실시간으로 서로간의 의사소통과 정보의 공유가 가능하게 되었다. 이로 인해 SNS는 빠르게 대중화가 이루어졌고 오늘날엔 SNS의 영역이 사회 전반으로 확대되면서 경제적, 사회적 가치를 지니게 기업들은 SNS를 통해 마케팅 전략을 세우거나 소셜커머스로 사용자들과 전자상거래를 하게 되었고, 개인들은 다른 사용자와 특정 이슈에 대해 견해를 교류하거나 정보를 공유하여 오프라인의 영역에도 영향을 미치게 빠른 대중화와 더불어 통한 이득을 보기 위해 사용자들은 개인정보를 SNS와 기업에게 제공하고 있다. 하지만 이러한 개인정보가 무분별하게 제공됨에 따라 사용자의 의지와 상관 없이 불법적으로 사용되는 사례가 빈번하게 발생하고 있고, 정보 프라이버시의 침해 우려는 사용자들이 지속적으로 사용하는 데에 있어서 큰 방해 요인 중 하나가 실제로 이를 시스템적으로 최대한 보호해주는 폐쇄형 SNS가 등장함에 많은 SNS에 몰리고...

The purpose of this study was to investigate the effects different saddle heights on lower-limb joint angle and muscle activity. Six elite cyclists(age: <TEX>$32.2{\pm}5.2years$</TEX>, height: <TEX>$171.0{\pm}3.5cm$</TEX>, weight: <TEX>$79.7{\pm}5.6kg$</TEX>, cycle career: <TEX>$13{\pm}6.2years$</TEX>) participated in three min. submaximal(90 rpm) pedaling tests with same load cadence based where subject's height determined by his knee flexion when pedal crank at 6 o'clock position. Joint...

A panel of six different murine hybridoma clones secreting IgG monoclonal antibodies (MAbs) specific for the human IgM Fc receptor (FcμR) was generated. All MAbs specifically precipitated a major protein ∼60 kDa from membrane lysates FcμR-bearing, but not FcμR-negative, cells as did IgM-ligands. Pre-incubation lysate FcμR-bearing with these completely removed IgM-reactive protein. By using recombinant human/mouse chimeric FcμR proteins, epitope recognized by HM7 and HM10 mapped to Ig-like...

The purpose of this study was to investigate the changes in walking pattern elderly during inclined walkway with uneven surfaces and level walking. 10 young(26.3±1.3 years, 174.3±5.3 cm, 69.5±9.5 kg) 13 elderly(72.4±5.2 164.5±5.4 66.1±9.6 male subjects were participated experiment. Experiment consisted 2 conditions: horizontal surfaces. 3D motion capturing system used acquire analyze data sampling frequency 120 Hz. To compare differences between conditions, kinematic variables(walking speed,...

This study was designed to evaluate the efficacy of a fat clearing technique for accurate nodal staging rectal cancer patients after preoperative chemoradiotherapy (CRT).A total 19 with within 10 cm from anal verge were divided into two groups: non-CRT group (n = 10) and CRT 9). For pathologic assessment, lymph node (LN) harvest performed using conventional manual dissection followed by technique.A median 3.0 additional LNs in 3.8 identified technique. When subanalysis fewer than 12...

[Purpose] This study aimed to determine appropriate measures for assessing balance ability according difficulty level during standing tasks. [Subjects and Methods] The subjects were 56 old (>65 years) 30 young (20–30 adults. By using the Berg scale, divided into three groups: 29 healthy older (Berg score≥52), 27 impaired score≥40), score≥55). One inertial measurement unit sensor was attached at waist, performed tasks (1 min/task) with six levels: eyes open closed on firm ground, one foam,...

[Purpose] The purpose of this study was to compare the differences in muscle strength and postural balance between fallers non-fallers. We also compared difference normal impaired groups using same subjects variables. [Subjects Methods] Seventy-one healthy elderly females (age: 75.1 ± 75 years; weight: 57.3 57 kg; height: 150.1 15 cm) who had high levels physical activity participated [25 (FG) vs. 46 non-fallers (NG); 52 group (HBG) 19 (IBG) subjects]. To groups, strengths 9 20 variables...

The purpose of this study was to develop an electric riding machine for cycle fitting control posture easily, measure frame size quantitatively, and overcome disadvantages the traditional systems. consisted actuator, load controller, display & unit. actuator unit by BLDC(BrushLess Direct Current) motor drives saddle height up down, crank forward backward, handlebar backward. controller controls loads Eddy current with electromagnet aluminum circular plate. panel which shows top tube...

Portable low-cost Kinect sensor was used to analyze standing balance ability of the elderly. Eighty subjects who can walk alone and have a normal cognitive level participated in this experiment. Based on Berg Balance scale (BBS) test with 52 points, were divided into Healthy older (HO: 46 persons, BBS: 53.80 ± 1.19) Impaired (IO: 34 49.06 2.03) group. Each subject performed 30 seconds four different tests (EO: Eyes Open, EC: Close, EOf: Open foam, ECf: Close foam). Five variables (Mean...

A method for detecting shockable rhythm was proposed. single feature extracted using the discrete wavelet transform from a single-channel electrocardiogram. The applied to support vector machine determine whether signal or non-shockable rhythm. To evaluate performance, five-fold cross validation performed with different window lengths (WLs). As result, sensitivity of 97.8% and specificity 98.0% 3 s WL were obtained. results represent proposed shows high detection performance even short...