A5100450471- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA modifications and cancer
- Genomics and Chromatin Dynamics
- RNA Research and Splicing
- Osteoarthritis Treatment and Mechanisms
- Autophagy in Disease and Therapy
- RNA and protein synthesis mechanisms
- Bone Metabolism and Diseases
- Epigenetics and DNA Methylation
- Eosinophilic Disorders and Syndromes
- Ferroptosis and cancer prognosis
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- RNA Interference and Gene Delivery
- Glycosylation and Glycoproteins Research
- Sirtuins and Resveratrol in Medicine
- Acute Myeloid Leukemia Research
- Cancer, Lipids, and Metabolism
- Photosynthetic Processes and Mechanisms
- Angiogenesis and VEGF in Cancer
- Microbial Metabolic Engineering and Bioproduction
- Cancer Mechanisms and Therapy
- Atherosclerosis and Cardiovascular Diseases
- Bioinformatics and Genomic Networks
- Genomics and Phylogenetic Studies
South China University of Technology
2021-2025
Hebei Medical University
2025
Hubei Normal University
2025
Second Hospital of Hebei Medical University
2025
Shanghai Sixth People's Hospital
2018-2025
Lanzhou University Second Hospital
2012-2024
Hangzhou Medical College
2023-2024
Beijing Tongren Hospital
2021-2024
Lanzhou University
2012-2024
State Key Laboratory of Oral Diseases
2018-2024
BackgroundCooking practice has transitioned from use of solid fuels to clean fuels, with addition better ventilation facilities. However, the change in mortality risk associated such a transition remains unclear.MethodsThe China Kadoorie Biobank (CKB) Study enrolled participants (aged 30–79 years) ten areas across China; we chose study five urban where for cooking was prevalent. Participants who reported regular (weekly or more frequently) at baseline were categorised as persistent fuel...
High-grade serous ovarian cancer (HGSOC) is one of the most common epithelial malignancies. tRNA-derived fragments (tRFs) have been identified as novel potential biomarkers and targets for therapy. Nevertheless, influence tRFs on HGSOC remains unknown. This study aimed to identify HGSOC-associated investigate function mechanism key in SK-OV-3 cells.The tRF profiles patients controls were investigated using small RNA sequencing. Differentially expressed verified by real-time PCR, a was...
Excessive formation of neutrophil extracellular traps (NETs) may lead to myositis-related interstitial lung disease (ILD). There is evidence that NETs can directly injure vascular endothelial cells and play a pathogenic role in the inflammatory exudation ILD. However, specific mechanism unclear. This study aimed investigate underlying NET-induced injury human pulmonary microvascular (HPMECs). HPMECs were stimulated with (200 ng/ml) vitro. Cell death was detected by propidium iodide staining....
The conserved Musashi (Msi) family of RNA binding proteins are expressed in stem/progenitor and cancer cells, but generally absent from differentiated consistent with a role cell state regulation. We found that Msi genes rarely mutated frequently overexpressed human cancers associated an epithelial-luminal state. Using ribosome profiling RNA-seq analysis, we regulate translation implicated epithelial biology epithelial-to-mesenchymal transition (EMT), promote splicing pattern. Overexpression...
Hepatocellular carcinoma (HCC), the most common form of primary liver cancer, is third leading cause cancer-related death in human. Alcohol a known risk factor for HCC. However it still unclear whether and how alcohol enhances progression metastasis existing We first retrospectively investigated 52 HCC patients (24 alcohol-drinkers 28 non-drinkers), found positive correlation between consumption advanced Tumor-Node-Metastasis (TNM) stages, higher vessel invasion poorer prognosis. In vitro...
Abstract Long noncoding RNA KCNQ1OT1 participates in the regulation of imprinted genes within kcnq1 domain. But its roles carcinogenesis and metastasis remain largely elusive. Herein, we evaluated potential non‐small‐cell lung cancer (NSCLC) progression. We demonstrated that level was upregulated NSCLC tissues cell lines. High correlated with poor overall progression‐free survival patients. facilitated proliferation, migration, invasion H460 cells. Furthermore, knockdown reduced expression...
Abstract Medicinal applications of gold complexes have recently attracted attention due to their innovative antitumor mechanisms. In this work, two hypercoordinated carbon-centered clusters PAA4 and PAA5 are quantitatively synthesized by an intramolecular 6- exo - dig cyclization polymetalated precursors. The on-bench in vitro experimental studies demonstrate that the characteristic hypercarbon-tetragold(I) multi-center bonding not only guarantees stability under common physiological...
Summary Plenty of rainfall but unevenly seasonal distribution happens regularly in southern China. Seasonal drought from summer to early autumn leads citrus fruit acidification, how regulates citrate accumulation remains unknown. Herein, we employed a set physiological, biochemical, and molecular approaches reveal that CsABF3 responds stress modulates fruits by directly regulating CsAN1 CsPH8 . Here, demonstrated irreversible acidification is caused lasting for > 30 d during the...
We have recently shown that a 150-bp Col10a1 distal promoter (-4296 to -4147 bp) is sufficient direct hypertrophic chondrocyte-specific reporter (LacZ) expression in vivo. More recently, through detailed sequence analysis we identified two putative tandem-repeat Runx2 binding sites within the 3'-end of this region (TGTGGG-TGTGGC, -4187 -4176 bp). Candidate electrophoretic mobility shift assay (EMSA), chromatin immunoprecipitation, and transfection studies demonstrate these bind mediate...
Abstract Runx2 is a known master transcription factor for osteoblast differentiation, as well an essential regulator chondrocyte maturation. Recently, more and data has shown that regulates hypertrophic chondrocyte‐specific type X collagen gene ( Col10a1 ) expression in different species. However, how regulation of impacts maturation, step endochondral bone formation, remains unknown. We have recently generated transgenic mice which Flag‐tagged was driven by cell‐specific control element....
Abstract Heterologous production of naringenin, a valuable flavonoid with various biotechnological applications, was well studied in the model organisms such as Escherichia coli or Saccharomyces cerevisiae . In this study, synergistic co‐culture system developed for naringenin from xylose by engineering microorganism. A long metabolic pathway reconstructed engineering. addition, critical gene 4‐coumaroyl‐CoA ligase ( 4CL ) simultaneously integrated into yeast genome multi‐copy free plasmid...
RNA interference (RNAi) technology has shown great promise for the treatment of cancer and other genetic disorders. Despite efforts to increase target tissue distribution, safe effective delivery siRNA diseased cells with sufficient cytosolic transport is another critical factor successful RNAi clinical application. Here, constructed lipid-based liquid crystalline nanoparticles, called nano-Transformers, can transform thestructure in intracellular acidic environment perform high-efficient...
To analyze the role of six human epididymis protein 4 (HE4)-related mitochondrial ribosomal proteins (MRPs) in ovarian cancer and selected MRPL15, which is most closely related to tumorigenesis prognosis cancer, for further analyses.Using STRING database MCODE plugin Cytoscape, MRPs were identified among genes that are upregulated response HE4 overexpression epithelial cells. The Cancer Genome Atlas (TCGA) GTEX, Oncomine, TISIDB used expression MRPs. prognostic impact genetic variation these...
A poly (lactide‐ co ‐glycolide) (PLGA) scaffold filled with fibrin gel, mesenchymal stem cells (MSCs) and poly(ethylene oxide)‐ b ‐poly ( L ‐lysine) (PEO‐ ‐PLL)/pDNA‐TGF‐β1 complexes was fabricated applied in vivo for synchronized regeneration of cartilage subchondral bone. The PEO‐ ‐PLL/pDNA‐TGF‐β1 could transfect MSCs vitro to produce TGF‐β1 situ up regulate the expression chondrogenesis‐related genes construct. heterogeneous declined along prolongation implantation time, lasted 3 6 weeks...
Abstract Background Little is known about the effects of maintaining healthy sleep patterns on frailty transitions. Methods Based 23,847 Chinese adults aged 30–79 in a prospective cohort study, we examined associations between and Healthy included duration at 7 or 8 h/d, without insomnia disorder, no snoring. Participants who persisted with pattern both surveys were defined as scored one point. We used 27 phenotypes to construct index three statuses: robust, prefrail, frail. Frailty...
Statins, acknowledged for their ability to reduce cardiovascular risk, demonstrate a variety of pleiotropic effects, including anti-inflammatory, antithrombotic, endothelial stabilizing activity and prevention acute kidney injury (AKI) post cardiac surgery. Patients in the intensive care unit (ICU) face heightened risks disease, infections, thrombotic complications, but effect statin therapy on ICU mortality remains controversial. The Medical Information Mart Intensive Care IV (MIMIC-IV)...