A5079051095- Lipoproteins and Cardiovascular Health
- Genetic factors in colorectal cancer
- Cancer, Lipids, and Metabolism
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Pharmacogenetics and Drug Metabolism
- RNA Research and Splicing
- Lipid metabolism and disorders
- Genetic Associations and Epidemiology
- RNA modifications and cancer
- Extracellular vesicles in disease
- Genomics and Rare Diseases
- Computational Drug Discovery Methods
- PI3K/AKT/mTOR signaling in cancer
- Biotechnology and Related Fields
- Veterinary Oncology Research
- Infectious Diseases and Mycology
- Blood Pressure and Hypertension Studies
- Vitamin C and Antioxidants Research
- Statistical Methods in Clinical Trials
- Eicosanoids and Hypertension Pharmacology
- Cancer Genomics and Diagnostics
- HIV/AIDS drug development and treatment
- Biochemical and Molecular Research
- Drug Transport and Resistance Mechanisms
- COVID-19 Clinical Research Studies
Universidade de São Paulo
2016-2025
Universidade Estadual de Campinas (UNICAMP)
2024-2025
PharmacoGenetics (China)
2024
Karolinska Institutet
2020-2022
Instituto de Ciências Farmacêuticas
2022
Ibero American University
2017
Universidade Estadual Paulista (Unesp)
2016
Abstract Background Inter-individual differences in dihydropyrimidine dehydrogenase ( DPYD encoding DPD) and thiopurine S-methyltransferase (TPMT) activity are important predictors for fluoropyrimidine toxicity. While several variants these genes known to decrease enzyme activities, many additional genetic variations with unclear functional consequences have been identified, complicating informed clinical decision-making the respective carriers. Methods We used a novel pharmacogenetically...
Statins, acknowledged for their ability to reduce cardiovascular risk, demonstrate a variety of pleiotropic effects, including anti-inflammatory, antithrombotic, endothelial stabilizing activity and prevention acute kidney injury (AKI) post cardiac surgery. Patients in the intensive care unit (ICU) face heightened risks disease, infections, thrombotic complications, but effect statin therapy on ICU mortality remains controversial. The Medical Information Mart Intensive Care IV (MIMIC-IV)...
Background/Objectives: Lung cancer has a high mortality rate worldwide, with non-small cell lung (NSCLC) being the most prevalent. Carboplatin and paclitaxel are key treatments for NSCLC; however, adverse drug reactions (ADRs) pose significant challenges. This study examined impact of genetic variations in ABCB1 ABCC2 genes on incidence ADRs survival NSCLC patients treated carboplatin paclitaxel. Methods: Variants were identified using RT-PCR, classified according to Common Toxicity Criteria...
To evaluate which indirect method for assessing adherence best reflects highly active antiretroviral therapy (HAART) effectiveness and the factors related to adherence.This descriptive, cross-sectional study was performed in 2012 at a reference center of state São Paulo. Self-report (simplified medication questionnaire [SMAQ]) drug refill parameters were compared viral load (clinical parameter pharmacotherapy [EP]) EP. The "Cuestionario para la Evaluación de Adhesión al Tratamiento...
Oral mucosal melanoma (OMM) is the most common oral cancer in dogs and very aggressive this species; its risk factors etiology are yet to be determined. This study aimed unravel for development of OMM investigate possible presence papillomaviruses as an etiological factor. A case-control was conducted 15 with paired controls whose owners answered epidemiological questionnaire. swabs from same were subjected 16S rRNA sequencing microbiome analyses. In addition, DNA fragments had their...
Abstract: Statins are the most widely used cholesterol-lowering drugs for cardiovascular diseases prevention. However, some patients refractory to treatment, whereas others experience statin-related adverse events (SRAE). It has been increasingly important identify pharmacogenetic biomarkers predicting statin response and events. This case report describes a female patient with familial hypercholesterolemia (FH) who showed late rosuvastatin experienced myalgia on treatment. In first visit...
Aim: Functional analysis of PCSK9 3′UTR variants and mRNA–miRNA interactions were explored in patients with familial hypercholesterolemia (FH). Materials & methods: identified by exon-targeted gene sequencing. effects analyzed using silico vitro studies HEK293FT HepG2 cells. Results: Twelve detected 88 FH patients. c.*75C >T c.*345C disrupted miR-6875, miR-4721 miR-564. Transient transfection the decreased luciferase activity miR-564 mimics reduced expression Conclusion: has a possible role...
Abstract Coronavirus disease 2019 (COVID-19) is caused by Severe Acute Respiratory Syndrome 2 (SARS-CoV-2). Recent research has demonstrated how epigenetic mechanisms regulate the host–virus interactions in COVID-19. It also shown that microRNAs (miRNAs) are one of three fundamental regulation gene expression and play an important role viral infections. A pilot study published our group identified, through next-generation sequencing (NGS), miR-4433b-5p, miR-320b, miR-16–2-3p differentially...
Gefitinib is a selective inhibitor of the epidermal growth factor receptor that used to treat advanced and metastatic non-small cell lung cancer (NSCLC). Dermatological adverse reactions are most commonly associated with gefitinib treatment. The cause in individuals multifactorial. Pharmacogenetics an effective tool detect such reactions. This case report describes female patient NSCLC who was administered at dose 250 mg/day. However, due severe dermatological reactions, treatment...
Statins are the first-line treatment for familial hypercholesterolemia (FH), but response is highly variable due to genetic and nongenetic factors. Here, we explored association between variability in 114 Brazilian adult FH patients. Specifically, a panel of 84 genes was analyzed by exon-targeted gene sequencing (ETGS), functional impact variants pharmacokinetic (PK) assessed using an array functionality prediction methods. Low-density lipoprotein cholesterol (LDL-c) statins (reduction ≥...
Objectives This study explored the association of deleterious variants in pharmacodynamics (PD) genes with statin response and adverse effects patients familial hypercholesterolemia (FH) analyzed their potential on protein structure stability. Methods Clinical laboratory data were obtained from 144 adult FH treated statins. A panel 32 PD was by exon-targeted gene sequencing. Deleterious identified using prediction algorithms structural molecular modeling studies. Results total 102 predicted...
Oral mucosal melanomas (OMMs) are aggressive neoplasms commonly found in dogs but rare humans. Utilizing whole exome sequencing (WES), which focuses on protein-coding regions to reveal mutation profiles, we conducted a comparative analysis of canine OMM and human melanomas. This study involved DNA extraction, enrichment, from three cell lines (CMGD-2, CMGD-5, TLM-1), five frozen samples, line (MEMO), commercial skin melanoma (SK-MEL-28). The subsequent FASTQ files yielded final variant...