A5010251488- Lipoproteins and Cardiovascular Health
- Cardiac Valve Diseases and Treatments
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiac pacing and defibrillation studies
- Cancer, Lipids, and Metabolism
- Blood Pressure and Hypertension Studies
- Cardiac Structural Anomalies and Repair
- Alzheimer's disease research and treatments
- Liver Disease Diagnosis and Treatment
- Asthma and respiratory diseases
- Folate and B Vitamins Research
- Infective Endocarditis Diagnosis and Management
- Adipose Tissue and Metabolism
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Muscle metabolism and nutrition
- Cancer-related molecular mechanisms research
- Parkinson's Disease Mechanisms and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Hepatocellular Carcinoma Treatment and Prognosis
- Cardiac Arrhythmias and Treatments
- Cystic Fibrosis Research Advances
- Retinal Diseases and Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Eating Disorders and Behaviors
- RNA modifications and cancer
Centro Universitário de Patos de Minas
2024-2025
Faculdade de Medicina de São José do Rio Preto
2015-2024
University College London
2023-2024
Instituto Dante Pazzanese de Cardiologia
2023
Universidade de São Paulo
2007-2022
Universidade de Ribeirão Preto
2017
Universidade Federal de São Paulo
2013
Universidade Estadual Paulista (Unesp)
1994-2007
Universidade Estadual de Campinas (UNICAMP)
2000
Instituto de Moléstias Cardiovasculares
1987-1998
Schizophrenia is a complex psychiatric disorder that affects approximately twenty million people worldwide. Various factors have been associated with the physiopathology of this disease such as oxidative stress, which an imbalance between pro-oxidant and antioxidant molecules.This study evaluated association biomarkers stress response to pharmacological treatment among patients schizophrenia in context their clinical information, demographic data, lifestyle.A total 89 subjects were included,...
To analyze the lipid profile and its correlation with risk factors for cardiovascular diseases (CVD) among medicine students.We assessed 153 students, regardless of sex, age between 18 31 years old, submitted to analysis, including serum levels total cholesterol (TC), fraction low (LDLc), high (HDLc) very density (VLDLc) lipoproteins triglycerides (TG), besides life habits anthropometric data. Statistic analysis was employed, test Mann Whitney, chi-square test, Pearson's multivariate by...
To analyze the biochemical profile and to characterize metabolic syndrome (MS) in patients with cardiologic medical assistance using NCEP-ATPIII IDF definitions.Two hundred 140 controls were studied, considering total cholesterol (TC), HDL-cholesterol (HDLc), LDL-cholesterol (LDLc), VLDL-cholesterol (VLDLc), triglycerides (TG), fasting glycemia, abdominal waist hypertension. Significance level was defined as P<0.05.Patients showed increased glycemia levels (103+/-31.4 mg/dL) reduced HDLc...
Background : Several factors participate in the pathogenesis of Alzheimer's disease (AD), including free radicals, which when out balance with their antioxidant capacity contribute to oxidative stress process and neuronal death. The glutathione S-transferase (GST) polymorphisms are associated organism detoxification can help identification sub-groups that present susceptibility development AD. aim this study was analyze association GSTs , GSTP1 GSTT1 GSTM1 apolipoprotein E ( apoE ) AD...
O HIV, ao atacar o sistema imunológico, causa imunossupressão e predisposição a infecções oportunistas neoplasias, caracterizando AIDS. Apesar dos avanços no tratamento, carga global da doença permanece elevada, com milhões de pessoas infectadas novas sendo registradas anualmente. Diante disso, este trabalho teve como objetivo revisar literatura existente sobre epidemiologia do HIV em Minas Gerais, destacando as características demográficas, os grupos risco, estratégias tratamento prevenção....
A formação docente desempenha um papel crucial na inclusão de crianças com transtorno do espectro autista (tea) nas escolas regulares. qualidade da educação oferecida a esses alunos está diretamente ligada à capacitação dos professores, que devem ser preparados para lidar as especificidades tea. pesquisa busca analisar como impacta dessas crianças, identificando desafios enfrentados pelos professores e eficácia programas capacitação. hipótese principal é falta específica compromete...
The genetic basis for dementias is complex. A common polymorphism in the apolipoprotein E (APOE) gene considered to be major risk factor families with sporadic and late-onset Alzheimer's disease as well general population. distribution of alleles genotypes APOE (N = 68), other late-life 39), cognitively normal controls 58) was determined, also associated epsilon4 allele. Peripheral blood samples were obtained from a total 165 individuals living Brazil aged 65-82 years. Genomic DNA amplified...
Genetic and environmental factors affect the pathogenesis of Parkinson's disease (PD). variants enzyme glutathione S-transferases (GST) may be related to disease. This study aimed evaluate influence genetic GST (GSTT1/GSTM1) their association with exposure toxins in PD patients. We studied 254 patients 169 controls. The GSTM1/GSTT1 were analyzed by polymerase chain reaction. applied Fisher's exact test χ2 for statistical analysis (p<0.05). present absence GSTT1 GSTM1 similar null (0/0)...
Alzheimer's disease (AD) is a progressive neurodegenerative that takes the form of local overexpression cytokines and other inflammatory molecules. We investigated three single-nucleotide polymorphisms (SNP) interleukin 6 gene (IL
The absence of nocturnal blood pressure dipping (ND) identified by 24-h ambulatory monitoring (ABPM) correlates with a worse cardiovascular prognosis. renin-angiotensin system influences levels and the occurrence target organ damage (TOD). Thus, aim this study was to correlate angiotensin-converting enzyme gene (ACE) insertion/deletion (I/D) polymorphism profile TOD in hypertensive individuals.155 non-diabetic individuals on antihypertensive treatment underwent ABPM. Peripheral samples were...
We evaluated the influence of vascular endothelial growth factor (VEGF) -C936T polymorphism on prognosis hepatocellular carcinoma (HCC), cirrhosis, and hepatitis C virus (HCV) infection.Serum VEGF alpha-fetoprotein (AFP) levels were determined used to characterize sensitivity specificity.A total 285 subjects studied: 68 HCC, 118 43 HCV, 56 healthy controls.Prevalence serum AFP analyzed by polymerase chain reaction-restriction fragment length enzyme-linked immunosorbent assay,...
Polymorphisms in genes involved the atherosclerosis development, angiogenesis, and homocysteine (Hcy) metabolism could be risk factors for coronary artery disease (CAD).To evaluate effect of VEGF C-2578A MTHFR C677T polymorphisms on CAD, association these with severity extension atherosclerotic lesions Hcy concentrations.Two hundred forty-four subjects were evaluated by angiography included study (145 CAD 99 controls). The investigated PCR-SSCP PCR-RFLP techniques, respectively. Plasma was...
The pathogenesis of Parkinson's disease (PD) seems to involve genetic susceptibility neurodegeneration. APOE gene has been considered a risk factor for PD. This study aimed evaluate the association polymorphism with PD and its influence on lipid profile. We studied 232 patients 169 individuals without disease. was analyzed by PCR/RFLP. Fisher's exact test, chi-square, ANOVA, t-test (P < 0.05) were applied. APOE3/3 genotype prevalent in Controls = 0.713) followed APOE3/4 0.772). Both groups...