A5002038133- Lipoproteins and Cardiovascular Health
- Genetic factors in colorectal cancer
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cancer, Lipids, and Metabolism
- MicroRNA in disease regulation
- SARS-CoV-2 detection and testing
- SARS-CoV-2 and COVID-19 Research
- Chemotherapy-induced organ toxicity mitigation
- Genomics and Rare Diseases
- Lipid metabolism and disorders
- Genetic Associations and Epidemiology
- Cardiac Health and Mental Health
- Adipokines, Inflammation, and Metabolic Diseases
- Telemedicine and Telehealth Implementation
- RNA Research and Splicing
- Health Systems, Economic Evaluations, Quality of Life
- Cholesterol and Lipid Metabolism
- Blood Pressure and Hypertension Studies
- Tryptophan and brain disorders
- CRISPR and Genetic Engineering
- Drug Transport and Resistance Mechanisms
- RNA modifications and cancer
- Agricultural Innovations and Practices
- Inflammatory mediators and NSAID effects
- Respiratory viral infections research
Beneficência Portuguesa de São Paulo
2022-2025
PharmacoGenetics (China)
2024
Universidade de São Paulo
2014-2023
Instituto Dante Pazzanese de Cardiologia
2011-2023
Universidade Federal de São Paulo
2018
Center for Rheumatology
2014-2017
Universidade Estadual de Maringá
2016
The current COVID-19 pandemic demands massive testing by Real-time RT-PCR (Reverse Transcription Polymerase Chain Reaction), which is considered the gold standard diagnostic test for detection of SARS-CoV-2 virus. However, virus continues to evolve with mutations that lead phenotypic alterations as higher transmissibility, pathogenicity or vaccine evasion. Another big issue are in annealing sites primers and probes kits leading false-negative results. Therefore, here we identify N...
There is no strong evidence on the link between inflammatory profile and pattern of drug treatment response in depressive patients that could result Coronary Artery Disease occurrence.This study aimed to compare subclinical atherosclerosis markers, profile, BDNF production Resistant Depression (RD) or Bipolar Affective Disorder (BAD) under conventional treatment.The population evaluated was comprised 34 RD, 43 BAD, 41 controls. Subclinical markers were using ultrasonography, tomography,...
The Rondon Project, an initiative by the Brazilian Federal Government in collaboration with Higher Education Institutions, promotes actions to foster development of cities and communities across Brazil. project aims support local sustainable enhance citizenship among participants through socially focused projects. Key objectives include contributing civic education university students, integrating them into national participatory actions, fostering a sense social responsibility toward...
ATP-binding cassette (ABC) proteins are membrane transporters responsible for metabolites and active substances removal from cells. Their genes' variations have been associated with protein function expression defects. Familial Hypercholesterolemia (FH) patients hosting those alterations might compromise the efficacy of high-dose statin treatment, a primary therapeutic strategy. ABCC1 is member ABC-transporter superfamily, potentially relevant to pharmacological therapy responses toxicity...
O presente estudo tem como objetivo realizar uma análise das Atribuições do Enfermeiro Gestor nos Serviços de Urgência e Emergência versos Resolução Cofen nº 421 fevereiro 2012. percurso metodológico foi utilizado nas seguintes bases dados: Medical Literature Analysis and Retrievel Sistem Online (MEDLINE, Literatura Latino-Americana Caribe em Ciências da Saúde (LILACS), Biblioteca virtual saúde enfermagem, BDENF . Foram utilizadas as palavras-chaves dos Descritores (DeCS) “Enfermagem...
Abstract Background No biomarker is available for identifying cancer patients at risk of developing nephrotoxicity when treated with cisplatin. Methods We performed microRNA (miRNA) sequencing using plasma collected 5 days after cisplatin treatment (D5) from twelve head and neck without (grade ≥ 2 increased serum creatinine). The most differentially expressed miRNAs between the two groups were selected quantification baseline D5 in a larger cohort patients. association was evaluated by...
Serological testing is a powerful tool in epidemiological studies for understanding viral circulation and assessing the effectiveness of virus control measures, as case SARS-CoV-2, pathogenic agent COVID-19. Immunoassays can quantitatively reveal concentration antiviral antibodies. The assessment antibody titers may provide information on exposure, changes IgG levels are also indicative reduction circulation. In this work, we describe serological study evaluation IgM antibodies their...
LIGHT (TNFSF14) (rs2291668 and rs344560), lymphotoxin-alpha (LTA) (rs1041981
Abstract: Statins are the most widely used cholesterol-lowering drugs for cardiovascular diseases prevention. However, some patients refractory to treatment, whereas others experience statin-related adverse events (SRAE). It has been increasingly important identify pharmacogenetic biomarkers predicting statin response and events. This case report describes a female patient with familial hypercholesterolemia (FH) who showed late rosuvastatin experienced myalgia on treatment. In first visit...
Aim: Functional analysis of PCSK9 3′UTR variants and mRNA–miRNA interactions were explored in patients with familial hypercholesterolemia (FH). Materials & methods: identified by exon-targeted gene sequencing. effects analyzed using silico vitro studies HEK293FT HepG2 cells. Results: Twelve detected 88 FH patients. c.*75C >T c.*345C disrupted miR-6875, miR-4721 miR-564. Transient transfection the decreased luciferase activity miR-564 mimics reduced expression Conclusion: has a possible role...
Recent experimental evidence shows that sevoflurane can reduce the inflammatory response during cardiac surgery with cardiopulmonary bypass. However, this observation so far has not been assessed in an adequately powered randomized controlled trial.We plan to include one hundred patients undergoing elective coronary artery bypass graft who will be receive either volatile anesthetics or total intravenous anesthesia. The primary endpoint of study is assess by measuring PMN-elastase serum...
Statins are the first-line treatment for familial hypercholesterolemia (FH), but response is highly variable due to genetic and nongenetic factors. Here, we explored association between variability in 114 Brazilian adult FH patients. Specifically, a panel of 84 genes was analyzed by exon-targeted gene sequencing (ETGS), functional impact variants pharmacokinetic (PK) assessed using an array functionality prediction methods. Low-density lipoprotein cholesterol (LDL-c) statins (reduction ≥...
Aim: To explore the association of circulating miRNAs with adiposity, metabolic status and inflammatory biomarkers in patients syndrome (MetS). Methods: Serum levels 372 were measured (n = 6) without MetS by quantitative PCR array, dysregulated validated a larger cohort (MetS, n 89; non-MetS, 144). Results: In screening study, seven MetS, miR-421 remained increased validation study. was associated high risk insulin resistance hypertension correlated glycated hemoglobin, triacylglycerols,...
Warfarin stands as the most prescribed oral anticoagulant. New anticoagulants have been approved recently; however, their use is limited and reversibility techniques of anticoagulation effect are little known. Thus, our study's purpose was to develop algorithms for therapeutic monitoring patients taking warfarin based on opinion physicians who prescribe this medicine in clinical practice. The development algorithm performed two stages, namely: (i) literature review (ii) evaluation by using a...
Objectives This study explored the association of deleterious variants in pharmacodynamics (PD) genes with statin response and adverse effects patients familial hypercholesterolemia (FH) analyzed their potential on protein structure stability. Methods Clinical laboratory data were obtained from 144 adult FH treated statins. A panel 32 PD was by exon-targeted gene sequencing. Deleterious identified using prediction algorithms structural molecular modeling studies. Results total 102 predicted...