A5055811872- Public Health in Brazil
- Chemotherapy-induced organ toxicity mitigation
- MicroRNA in disease regulation
- Catalytic C–H Functionalization Methods
- Pharmaceutical Practices and Patient Outcomes
- Catalytic Cross-Coupling Reactions
- Pharmaceutical studies and practices
- Cyclopropane Reaction Mechanisms
- Patient Safety and Medication Errors
- Acute Lymphoblastic Leukemia research
- HIV/AIDS drug development and treatment
- Antioxidant Activity and Oxidative Stress
- Extracellular vesicles in disease
- Skin Protection and Aging
- HIV/AIDS Research and Interventions
- Nitric Oxide and Endothelin Effects
- Lung Cancer Treatments and Mutations
- Medication Adherence and Compliance
- Drug-Induced Adverse Reactions
- Head and Neck Cancer Studies
- Pharmacological Effects and Toxicity Studies
- Glutathione Transferases and Polymorphisms
- Pharmacovigilance and Adverse Drug Reactions
- Asymmetric Hydrogenation and Catalysis
- Oral health in cancer treatment
Universidade Estadual de Campinas (UNICAMP)
2016-2025
Hospital de Clínicas da Unicamp
2021
Instituto de Medicina Integral Professor Fernando Figueira
2019
Instituto Nacional del Carbón
2010-2015
Universidad de Oviedo
2004-2014
ETH Zurich
2007
Umeå University
2003
Universidade de São Paulo
1997-2003
Universidade Brasil
2002
Instituto de Ciências Farmacêuticas
2000-2001
Metal-free partner: No organometallic coupling partner is required for a Pd-catalyzed cross-coupling reaction that employs N-tosylhydrazones as the nucleophilic component (see scheme; Ts=4-toluenesulfonyl).
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 200 leading journals. To access Abstract, please click on HTML or PDF.
Due to the growing number of outbreaks infection in hospital and nurseries, it becomes essential set up a sanitation program that indicates appropriate chemical agent was chosen for application most effective way. Validating effectiveness decontamination disinfection is an important often challenging task. In order study compare behavior selected microorganisms, they were submitted minimal inhibitory concentration (MIC). The MIC intervals, which reduced bacteria populations over 6 log10,...
Nicht nur als Stickstoffquelle, sondern auch In-situ-Hydroxyaktivator wirkt Sulfaminsäure bei der direkten Ir-katalysierten Synthese von Allylaminen aus Allylalkoholen (siehe Schema; cod=Cyclooctadien). Die Reaktion wird durch einen käuflichen Iridiumkomplex und zweizähnigen, auf Phosphoramiditen basierenden Phosphor-Olefin-Liganden katalysiert.
Metallfreier Partner: Auch ohne metallorganischen Kupplungspartner führt eine palladiumkatalysierte Kreuzkupplung zum Ziel. Entscheidend hierfür sind N-Tosylhydrazone als die nucleophile Komponente (siehe Schema; Ts=4-Toluolsulfonyl). Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2001/2007/z701815_s.pdf or from author. Please note: The publisher not responsible content functionality of any supporting supplied by authors. Any queries...
Background The oxidative stress associated with HIV infection may be important for the progression of disease because reactive oxygen species activate nuclear transcription factor NF‐κB, which is obligatory replication. Patients and methods activities antioxidant enzymes superoxide dismutase (SOD, EC 1.15.1.1) glutathione peroxidase (GPx, 1.11.1.9) blood plasma peripheral mononuclear cells, as well levels ascorbate, α‐tocopherol β‐carotene, were measured in 75 subjects 26 controls....
Coronavirus disease 2019 (COVID-19) is caused by a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It known that host microRNAs (miRNAs) can be modulated to favor viral infection or protect the host. Herein, we report preliminary results of study aiming at identifying differentially expressed plasmatic miRNAs in Brazilian patients with COVID-19.miRNAs were extracted from plasma eight COVID-19 (four mild and four severe/critical COVID-19) healthy controls....
The redox pathophysiology of vascular repair is incompletely understood. We assessed the role superoxide dismutase (SOD) activity in oxidative/nitrative stress and caliber loss postinjury (PI).Rabbits submitted to iliac artery balloon overdistension were followed for 14 days PI. Significant decrease SOD occurred at 7 PI (by 45% 34%, respectively, versus control, 96+/-1 U/mg, P<0.05). Separation concanavalin-A column showed that both extracellular (ecSOD) CuZn activities reduced, whereas...
The cosmetic and pharmaceutical industries have an increasing interest in replacing synthetic antimicrobials dermatological products due to increased microbial resistance conventional antimicrobial agents. Pequi (Caryocar brasiliense) is a native fruit tree of the Brazilian Cerrado, specifically used cosmetics, food industry, for medicinal purposes. Leishmanicidal antifungal activities been reported previously. This study was designed evaluate antioxidant C. brasiliense extract obtained by...
What is known and objective Polymyxins were widely used until the 1960s; however, they fell into disfavour owing to their toxicity. The subsequent growth of infections caused by multidrug-resistant Gram-negative bacteria has led renewed use this class antimicrobials in clinical practice. Acquired skin hyperpigmentation (SH) following intravenous polymyxin B treatment been previously reported, but little about its pathogenesis, course treatment. To improve understanding these issues, we...
Head and neck squamous cell carcinoma (HNSCC) is treated with cisplatin (CDDP) radiotherapy (RT), distinct results are observed among patients similar clinicopathological aspects. This prospective study aimed to investigate whether MLH1 c.-93G>A (rs1800734), MSH2 c.211+9C>G (rs2303426), MSH3 c.3133G>A (rs26279), EXO1 c.1765G>A (rs1047840), c.2270C>T (rs9350) single nucleotide polymorphisms (SNPs) of the mismatch repair (MMR) pathway change side effects response rate 90 HNSCC CDDP RT. DNA...
The protective antioxidant activity of acetylcysteine (NAC) against toxicity due to cisplatin has been reported in experimental models; however, its efficacy patients not elucidated. aim this study was investigate the possible effect NAC on cisplatin-induced and clinical response oxidative stress treated for head neck cancer. This a randomized, double-blind, placebo-controlled trial conducted receiving high-dose chemotherapy concomitant radiotherapy. Patients were randomly assigned groups...
N-Boc-N-alkenylhydrazines, an almost unknown type of compounds, have been prepared with high to moderate yields via palladium-catalyzed cross-coupling between alkenyl halides and tert-butyl carbazate. The present methodology represents the first general way access this highly functionalized unusual hydrazines.
Background: Substantial complexity has been introduced into treatment regimens for patients with human immunodeficiency virus (HIV) infection. Many drug-related problems (DRPs) are detected in these patients, such as low adherence, therapeutic inefficacy, and safety issues. We evaluated the impact of pharmacist interventions on CD4+ T-lymphocyte count, HIV viral load, DRPs Methods: In this 18-month prospective controlled study, 90 outpatients were selected by convenience sampling from...
L-asparaginase (L-ASNase) is the gold standard enzyme used to treat acute lymphoblastic leukemia. This disease primarily affects children; however, treatment increases survival from 20% 90%. As a bioproduct, it obtained via biotechnological process and its purification usually consists of several steps that account for up 80% total production costs. review discusses available strategies L-ASNase highlights with fewer steps, consequently, lower cost higher yield. emphasizes possibility using...