Alfred Pozarickij
A5044296926- Genetic Associations and Epidemiology
- Ophthalmology and Visual Impairment Studies
- Corneal surgery and disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Birth, Development, and Health
- Cardiovascular Disease and Adiposity
- Lipoproteins and Cardiovascular Health
- RNA Research and Splicing
- Advanced Proteomics Techniques and Applications
- Folate and B Vitamins Research
- Bioinformatics and Genomic Networks
- Genetic and phenotypic traits in livestock
- Epigenetics and DNA Methylation
- Liver Disease Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Nutritional Studies and Diet
- Adipose Tissue and Metabolism
- Glaucoma and retinal disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Genetic Mapping and Diversity in Plants and Animals
- Paraoxonase enzyme and polymorphisms
- Cardiovascular Health and Risk Factors
- Health disparities and outcomes
- Hypothalamic control of reproductive hormones
- Intracerebral and Subarachnoid Hemorrhage Research
University of Oxford
2022-2025
Cardiff University
2018-2022
Tobacco smoking is estimated to account for more than 1 million annual deaths in China, and the epidemic continues increase men. Large nationwide prospective studies linked different health records can help periodically assess disease burden attributed smoking. We aimed examine associations of with incidence mortality from an extensive range diseases China.We analysed data China Kadoorie Biobank, which recruited 512 726 adults aged 30-79 years, whom 210 201 were men 302 525 women....
Abstract Alcohol consumption accounts for ~3 million annual deaths worldwide, but uncertainty persists about its relationships with many diseases. We investigated the associations of alcohol 207 diseases in 12-year China Kadoorie Biobank >512,000 adults (41% men), including 168,050 genotyped ALDH2 - rs671 and ADH1B rs1229984 , >1.1 ICD-10 coded hospitalized events. At baseline, 33% men drank regularly. Among men, intake was positively associated 61 diseases, 33 not defined by World...
Abstract Proteomics offers unique insights into human biology and drug development, but few studies have directly compared the utility of different proteomics platforms. We measured plasma levels 2168 proteins in 3976 Chinese adults using both Olink Explore SomaScan The correlation protein between platforms was modest (median rho = 0.29), with abundance data quality parameters being key factors influencing correlation. For 1694 one-to-one matched reagents, 765 513 had cis -pQTLs, including...
Integrated analyses of plasma proteomic and genetic markers in prospective studies can clarify the causal relevance proteins discover novel targets for ischemic heart disease (IHD) other diseases.
Integrated analyses of plasma proteomics and genetic data in prospective studies can help assess the causal relevance proteins, improve risk prediction, discover novel protein drug targets for type 2 diabetes (T2D).
Abstract Background Previous studies of primarily Western populations have reported contrasting associations dairy consumption with certain cancers, including a positive association prostate cancer and inverse colorectal premenopausal breast cancers. However, there are limited data from China where rates levels differ importantly those in populations. Methods The prospective Kadoorie Biobank study recruited ~0.5 million adults ten diverse (five urban, five rural) areas across during...
Evidence is sparse and inconclusive on the association between long-term fine (≤2.5 μm) particulate matter (PM
Abstract Background The relevance of folic acid for stroke prevention in low-folate populations such as China is uncertain. Genetic studies the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism, which increases plasma homocysteine (tHcy) levels, could clarify causal elevated tHcy levels stroke, ischaemic heart disease (IHD) and other diseases without fortification. Methods In prospective Kadoorie Biobank, 156 253 participants were genotyped MTHFR 12 240 developed a during...
Abstract Background Little is known about the effects of maintaining healthy sleep patterns on frailty transitions. Methods Based 23,847 Chinese adults aged 30–79 in a prospective cohort study, we examined associations between and Healthy included duration at 7 or 8 h/d, without insomnia disorder, no snoring. Participants who persisted with pattern both surveys were defined as scored one point. We used 27 phenotypes to construct index three statuses: robust, prefrail, frail. Frailty...
Abstract A genetic contribution to refractive error has been confirmed by the discovery of more than 150 associated variants in genome-wide association studies (GWAS). Environmental factors such as education and time outdoors also demonstrate strong associations. Currently however, extent gene-environment or gene-gene interactions myopia is unknown. We tested hypothesis that error-associated exhibit effect size heterogeneity, a hallmark feature interactions. Of 146 tested, evidence...
Abstract Adiposity is associated with multiple diseases and traits, but little known about the causal relevance mechanisms underlying these associations. Large-scale proteomic profiling, especially when integrated genetic data, can clarify linking adiposity disease outcomes. We examined associations of plasma levels 1463 proteins in 3977 Chinese adults, using measured genetically-instrumented BMI. further used two-sample bi-directional MR analyses to assess if certain influenced adiposity,...
Lowering low-density lipoprotein cholesterol (LDL-C) through PCSK9 inhibition represents a new therapeutic approach to preventing and treating cardiovascular disease (CVD). Phenome-wide analyses of genetic variants in large biobanks can help identify unexpected effects inhibition. In the prospective China Kadoorie Biobank, we constructed score using three at locus associated with directly measured LDL-C [PCSK9 (PCSK9-GS)]. Logistic regression gave estimated odds ratios (ORs) for PCSK9-GS...
Myopia most often develops during school age, with the highest incidence in countries intensive education systems. Interactions between genetic variants and educational exposure are hypothesized to confer susceptibility myopia, but few such interactions have been identified. Here, we aimed identify that interact level myopia. Two groups of unrelated participants European ancestry from UK Biobank were studied. A ‘Stage-I’ sample 88,334 whose refractive error ( avMSE ) was measured by...
BackgroundPrevious observational studies established a positive relationship between snoring and stroke. We aimed to investigate the causal effect of on stroke.MethodsBased 82,339 unrelated individuals with qualified genotyping data Asian descent from China Kadoorie Biobank (CKB), we conducted Mendelian randomization (MR) analysis Genetic variants identified in genome-wide association (GWAS) CKB UK (UKB) were selected for constructing genetic risk scores (GRS). A two-stage method was applied...
The relationships between long-term blood pressure (BP) measures and intracerebral haemorrhage (ICH), as well their predictive ability on ICH, are unclear. In this study, we aim to investigate the independent associations of multiple BP with subsequent 5-year ICH risk, incremental value these over a single-point measurement in risk prediction.
Abstract Plasma proteomics could enhance risk prediction for multiple diseases beyond conventional factors or polygenic scores (PS). To assess utility of ischemic heart disease (IHD) compared with and PS in Chinese European populations. A nested case-cohort study measured plasma levels 2923 proteins using Olink Explore panel ~ 4000 adults (1976 incident IHD cases 2001 sub-cohort controls). We used machine learning (Boruta) methods to develop proteomics-based models IHD, discrimination...
Abstract Proteomics offers unique insights into human biology and drug development, but few studies have directly compared the utility of different proteomics platforms. We measured 2,168 plasma proteins in 3,976 Chinese adults using both OLINK SomaScan platforms their genetic determinants associations with traits disease risk. For 1,694 one-to-one matched reagents, there was a modest between platform correlation (median rho=0.20). OLINK-proteins had fewer trans- pQTLs (766 vs 812 proteins)...
Purpose: To test the hypothesis that emmetropization buffers against genetic and environmental risk factors for myopia by investigating whether factor effect sizes vary depending on children's position in refractive error distribution. Methods: Refractive was assessed participants from two birth cohorts: Avon Longitudinal Study of Parents Children (ALSPAC) (noncycloplegic autorefraction) Generation R (cycloplegic autorefraction). A score calculated genotypes at 146 loci. Time spent reading,...
Abstract Genome-wide association studies (GWAS) have revealed that the genetic contribution to certain complex diseases is well-described by Fisher’s infinitesimal model in which a vast number of polymorphisms each confer small effect. Under model, variants additive effects both across loci and within loci. However, latter assumption at odds with common observation dominant or recessive rare alleles responsible for monogenic disorders. Here, we searched evidence non-additive (dominant...
A comprehensive depiction of long-term health impacts marital status is lacking.
Abstract The proteome is fundamental to human biology and health but little known about ancestral diversity of its genetic determinants. In GWAS plasma levels 2,923 proteins in 3,974 Chinese adults, we identified pQTLs for 1,784 proteins, including 1,312 cis -pQTLs 1,264 proteins. Fine-mapping 3,475 credible sets independent pQTLs, 36% which were distinct from those European adults as assessed by three different methods. phenome-wide MR analyses, 59 disease associations strong LD (r 2...
The prevalence of atrial fibrillation (AF) is positively correlated with prior cardiovascular diseases (CVD) and CVD risk factors but lower in Chinese than Europeans despite their higher burden CVD. We examined the prognosis AF other electrocardiogram (ECG) abnormalities China Kadoorie Biobank.