Ka Hung Chan
A5101817500- Air Quality and Health Impacts
- Energy and Environment Impacts
- Climate Change and Health Impacts
- Genetic Associations and Epidemiology
- Advanced Numerical Methods in Computational Mathematics
- Air Quality Monitoring and Forecasting
- Ethics in Clinical Research
- Global Cancer Incidence and Screening
- Spaceflight effects on biology
- Contact Mechanics and Variational Inequalities
- Cardiovascular Function and Risk Factors
- Computer Graphics and Visualization Techniques
- Impact of Light on Environment and Health
- Global Health Care Issues
- Vibration and Dynamic Analysis
- Advanced Mathematical Modeling in Engineering
- Genetic Syndromes and Imprinting
- Geological Modeling and Analysis
- Colorectal Cancer Screening and Detection
- Energy, Environment, and Transportation Policies
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Disease and Adiposity
- Ovarian cancer diagnosis and treatment
- Health Systems, Economic Evaluations, Quality of Life
- Health, Environment, Cognitive Aging
University of Oxford
2018-2025
Science Oxford
2024
British Heart Foundation
2021-2023
Few cohort studies explored the long-term effects of ambient fine particulate matter (PM2.5) on incidence cardiovascular diseases (CVDs), especially in countries with higher levels air pollution. We aimed to evaluate association between exposure PM2.5 and CVD China. performed a prospective study ten regions that recruited 512,689 adults during 2004–2008, follow-up until 2017. Annual concentrations were estimated using satellite-based model national coverage 1 x km spatial resolution....
Evidence is sparse and inconclusive on the association between long-term fine (≤2.5 μm) particulate matter (PM
This paper presents efficient coupling methods that accurately reduce the computational cost for modelling solids dynamically with finite elements. A multi-time step integration algorithm is developed to leverage varying time steps throughout a domain. Interfaces between subdomains are resolved explicitly continuity of acceleration and tractions. spatial method combined multiple steps, allowing meshes do not necessarily conform at their interfaces. The avoids solving additional degrees...
This paper presents efficient coupling methods that accurately reduce the computational cost for modelling solids dynamically with finite elements. A multi-time-step integration algorithm is developed to leverage varying time steps throughout a domain. Interfaces between subdomains are resolved explicitly continuity of acceleration and tractions. spatial method combined multiple steps, allowing meshes do not necessarily conform at their interfaces. The avoids solving additional degrees...
Over 3.5 billion individuals worldwide are exposed to household air pollution from solid fuel use. There is limited evidence cohort studies on associations of use with risks major eye diseases, which cause substantial disease and economic burden globally.
Abstract Background Lung cancer is the leading cause of mortality among Chinese females despite low smoking prevalence this population. This study assessed roles reproductive factors in lung development female never-smokers. Methods The prospective China Kadoorie Biobank (CKB) recruited over 0.5 million adults (0.3 females) from 10 geographical areas 2004–2008 when information on socio-demographic/lifestyle/environmental factors, physical measurements, medical history, and history collected...
BackgroundPrevious observational studies established a positive relationship between snoring and stroke. We aimed to investigate the causal effect of on stroke.MethodsBased 82,339 unrelated individuals with qualified genotyping data Asian descent from China Kadoorie Biobank (CKB), we conducted Mendelian randomization (MR) analysis Genetic variants identified in genome-wide association (GWAS) CKB UK (UKB) were selected for constructing genetic risk scores (GRS). A two-stage method was applied...
The prevalence of atrial fibrillation (AF) is positively correlated with prior cardiovascular diseases (CVD) and CVD risk factors but lower in Chinese than Europeans despite their higher burden CVD. We examined the prognosis AF other electrocardiogram (ECG) abnormalities China Kadoorie Biobank.
ABSTRACT Heterogeneous solids often exhibit complex dynamic behavior, requiring simulations to use varying time steps. However, the conventional of a single‐time step for entire domain can be inefficient. This article proposes multi‐time stepping algorithm that addresses this challenge by relaxing constraint an integer or constant ratio between subdomains and eliminating need kinematic interpolation. The ensures satisfaction Courant‐Friedrichs‐Lewy condition, deviating only allow remain in...
Higher body mass index (BMI) is associated with higher incidence of cardiovascular and some non-cardiovascular diseases (CVDs/non-CVDs). However, uncertainty remains about its associations mortality, particularly at lower BMI levels.
TPS 722: Low and middle income countries: indoor air pollutants, Exhibition Hall, Ground floor, August 28, 2019, 3:00 PM - 4:30 Background: Exposure to solid fuel smoke has been linked excess risk of cataract, a leading cause preventable vision loss impairment affecting 70 million individuals globally. However, this based on small case-control studies, with little information other common eye diseases. Methods: During 2004-2008, 510,520 Chinese adults (mean age: 52 years, 59% female) were...
Abstract Background Household air pollution (HAP) has been classified as a major risk factor for lung cancer (LC) among never-smokers, however, evidence is largely from case-control studies. Using the prospective cohort China Kadoorie Biobank (CKB), we investigated association of HAP with LC death never-smokers. Methods The CKB, large-scale study, recruited 512,715 adults aged 30–79 years ten regions in during 2004-2008. Self-reported never-smoking participants were followed up to 31/12/2016...
Background/Aim: Exhaled carbon monoxide (COex) is increasingly used as a biomarker for household air pollution (HAP) exposure, but there uncertainty about the findings that highlights need reliable evidence. We investigated association between COex and self-reported HAP exposure in 0.5 million adults. Methods: The China Kadoorie Biobank recruited adults aged 30-79 years from 10 diverse localities of 2004-2008. At baseline, participants undertook measurement reported fuel-related exposure....
The use of indoor air purifier (IAP) has received growing attention as a mitigation strategy for reducing pollution, but the evidence on their cardiovascular benefits is unclear. This study aims to evaluate whether IAP can reduce adverse effects particulate matter (PM) health among young healthy population. A randomized, double-blind, cross-over, intervention 38 college students was conducted. participants were assigned into two groups receive true and sham IAPs 36 h in random order....