A5050418779- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Acute Myeloid Leukemia Research
- Peripheral Neuropathies and Disorders
- Blood groups and transfusion
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Multiple Myeloma Research and Treatments
- Immunodeficiency and Autoimmune Disorders
- Platelet Disorders and Treatments
- Autoimmune Bullous Skin Diseases
- Venous Thromboembolism Diagnosis and Management
- Chronic Myeloid Leukemia Treatments
- Hemoglobinopathies and Related Disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Erythrocyte Function and Pathophysiology
- Myasthenia Gravis and Thymoma
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Protein Degradation and Inhibitors
- Respiratory Support and Mechanisms
- Asthma and respiratory diseases
- Acute Lymphoblastic Leukemia research
- Pancreatitis Pathology and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Medical Imaging and Pathology Studies
- Blood Coagulation and Thrombosis Mechanisms
China-Japan Friendship Hospital
2012-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2014-2025
Northwest A&F University
2025
Tianjin Medical University
2024-2025
University of British Columbia
2025
National Clinical Research Center for Digestive Diseases
2015-2025
University of South Florida
2020-2024
Second Hospital of Tianjin Medical University
2024
Academy of Medical Sciences
2024
National Clinical Research
2024
Abstract Alcohol consumption accounts for ~3 million annual deaths worldwide, but uncertainty persists about its relationships with many diseases. We investigated the associations of alcohol 207 diseases in 12-year China Kadoorie Biobank >512,000 adults (41% men), including 168,050 genotyped ALDH2 - rs671 and ADH1B rs1229984 , >1.1 ICD-10 coded hospitalized events. At baseline, 33% men drank regularly. Among men, intake was positively associated 61 diseases, 33 not defined by World...
Polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome is a rare plasma dyscrasia without standard treatment. This phase II prospective trial evaluates the safety response of 12 cycles low dose lenalidomide (10 mg) plus dexamethasone (Rdex) in patients with newly diagnosed POEMS syndrome. Forty-one (28 men) were enrolled median age at diagnosis was 49 years (range, 21-70 years). Twenty-one (46%) achieved complete hematologic neurologic rate...
Cancer is one of the deadliest diseases to humanity. There significant progress in treating this disease, but developing some drugs that can fight disease remains a challenge field medical research. Thirteen new 1,2,3-triazole linked tetrahydrocurcumin derivatives were synthesized by click reaction, including 1,3-dipolar cycloaddition reaction baring mono-alkyne with azides good yields, and their vitro anticancer activity against four cancer cell lines, human cervical carcinoma (HeLa), lung...
ABSTRACT The escalating threat of antibiotic-resistant bacteria has heightened global interest in antimicrobial peptides as promising candidates due to their potent broad-spectrum activity and low likelihood resistance development. Despite this potential, these face challenges, including modest bactericidal efficacy, insufficient safety assessment, expensive production. In study, we systematically evaluated a panel nine AMP variants PGLa, natural derived from Xenopus laevis . All retained...
Abstract Background Inflammatory bowel disease (IBD), encompassing Crohn’s (CD) and ulcerative colitis (UC), is marked by chronic inflammation along the gastrointestinal tract (GIT). IBD cases are rising globally, with Canada having one of highest prevalance rates. Thus, there a critical need for more effective treatments. Current therapy includes orally administered small molecule anti-inflammatory drugs, such as corticosteroids JAK inhibitors. However, their use limited high doses required...
BACKGROUND Severe acute pancreatitis is a severe abdominal disease. Signs and symptoms classically vary from pain to fever, vomiting, distension. complications, such as infected pancreatic necrosis multiple organ dysfunction syndrome, can occur. The various treatment strategies in necrotizing include percutaneous drainage, laparoscopic necrosectomy, endoscopic minimally invasive or more hazardous open surgery. In the presently described case, effect of puncture drainage was not significant,...
Introduction: Intra-abdominal hemorrhage is a rare yet life-threatening complication of acute pancreatitis (AP), with higher prevalence in cases severe (SAP). This condition primarily caused by vessel wall erosion and rupture pseudoaneurysms (PSAs). However, SAP involving multiple sequential arterial hemorrhages are extremely rare. brought on the process degeneration development PSAs. Nonetheless, necessitating episodes bleeding very uncommon. Case Presentation: Here case history 31-year-old...
Abstract Background: Glucocorticoids are widely used for managing acute exacerbations of chronic obstructive pulmonary disease (AECOPD); however, limited studies have described the comparative effectiveness inhaled corticosteroids (ICS), systemic administered orally or intravenously (oral/intra), and a combination ICS oral/intra AECOPD treatment in China. Thus, we aimed to explore effects different glucocorticoid administration routes during hospitalization on both short- long-term patient...
To evaluate the safety of adalimumab in pediatric patients who participated clinical trials juvenile idiopathic arthritis (polyarticular and enthesitis-related arthritis), psoriasis, Crohn's disease.This analysis included data from 7 global, randomized, open-label AbbVie-sponsored their extensions conducted between September 2002 December 31, 2015 (cutoff date for ongoing studies). Patients received ≥1 dose subcutaneously were included. Adverse events that occurred after first up to 70 days...
Abstract Recombinant hemopoietic colony‐stimulating factors (CSFs), including GM‐CSF, G‐CSF and IL‐3, have been shown to be effective stimulators of both self‐renewal terminal differentiation blast stem cells in acute myeloblastic leukemia (AML). We examined the activity a fourth growth factor, recombinant CSF‐1 (or M‐CSF), on leukemic blasts culture. was found active some, but not all, populations. In sensitive cells, often stimulated production adherent incapable division. This observation...
Abstract Although autologous stem cell transplantation or melphalan‐based chemotherapy has significantly improved the prognosis of POEMS syndrome, a few patients will relapse be refractory to primary therapy, and there is lack studies regarding these patients. In this study, we used low‐dose lenalidomide (10 mg daily) dexamethasone (40 mg, once weekly) treat twelve with relapsed ( n = 8) 4) syndrome. After median follow‐up time 20 months, overall hematologic response rate was 77% 44% having...
Polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes (POEMS) syndrome is a multisystem disorder arising from underlying plasma cell dyscrasia. Renal impairment related pathological have been reported, but data on its prevalence, response to therapy impact survival are still lacking. We retrospectively reviewed 299 patients diagnosed with POEMS in tertiary-care university hospital 2000 until 2014. The estimated glomerular filtration rate (eGFR) was used define...
In order to enhance the detection rate of multiple myeloma and execute an early more precise disease management, artificial intelligence assistant diagnosis system is developed.4,187 routine blood biochemical examination records were collected from Shengjing Hospital affiliated China Medical University January 2010 2020, which include 1,741 (MM) 2,446 non-myeloma (infectious diseases, rheumatic immune hepatic diseases renal diseases). The data set was split into training test subsets with...