A5042905034- Antimicrobial Resistance in Staphylococcus
- Bacterial biofilms and quorum sensing
- Antimicrobial Peptides and Activities
- Biochemical and Structural Characterization
- Bacterial Genetics and Biotechnology
- Probiotics and Fermented Foods
- Antibiotic Resistance in Bacteria
- Protein Hydrolysis and Bioactive Peptides
- Gut microbiota and health
- Insect and Pesticide Research
- Biochemical Analysis and Sensing Techniques
Northwest A&F University
2015-2025
ABSTRACT The escalating threat of antibiotic-resistant bacteria has heightened global interest in antimicrobial peptides as promising candidates due to their potent broad-spectrum activity and low likelihood resistance development. Despite this potential, these face challenges, including modest bactericidal efficacy, insufficient safety assessment, expensive production. In study, we systematically evaluated a panel nine AMP variants PGLa, natural derived from Xenopus laevis . All retained...
The rise of antimicrobial resistance limits therapeutic options for infections by methicillin-resistant staphylococci. staphylococcal cassette chromosome mec (SCCmec) is a mobile genetic element as the only carrier methicillin-resistance determinants, mecA or mecC gene. use antibiotics increases spread antibiotic resistance, but mechanism which promote horizontal dissemination SCCmec largely unknown. In this study, we demonstrate that many antibiotics, including β-lactams, can induce...
The bla regulatory system is critical in the regulation of mecA expression particularly when staphylococci lack mec regulator. We sought to evaluate effect regulators on cryptic methicillin-resistant phenotype and resistance conversion under β-lactam exposure oxacillin-susceptible or oxacillin-resistant mecA-positive staphylococcal isolates.Methicillin-resistant isolates, NW19 DY39, their mutants, were used this study. Both DY39 carried intact mecA, a truncated mecR1 gene single copy system....
Staphylococcal cassette chromosome mec (SCCmec) typing is crucial for investigating methicillin-resistant Staphylococcus aureus (MRSA), relying primarily on the combination of ccr and gene complexes. To date, 19 genes 10 complexes have been identified, forming 15 SCCmec types. With vast release bacterial genome sequences, mining database novel SCC/SCCmec elements could enhance MRSA epidemiological studies. In this study, we identified 12 (6 ccrA, 3 ccrB, ccrC) through National Center...
Antibiotic tolerance allows bacteria to overcome antibiotic treatment transiently and potentially accelerates the emergence of resistance. However, our understanding at genetic level during adaptive evolution Staphylococcus aureus remains incomplete. We sought identify mutated genes verify role these in formation vancomycin S. aureus.Vancomycin-susceptible strain Newman was used induce vancomycin-tolerant isolates vitro by cyclic exposure under a high concentration (20× MIC). WGS Sanger...