A5100326441- Ferroptosis and cancer prognosis
- Gastric Cancer Management and Outcomes
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Gastrointestinal Tumor Research and Treatment
- Metastasis and carcinoma case studies
- MicroRNA in disease regulation
- Helicobacter pylori-related gastroenterology studies
- Lung Cancer Diagnosis and Treatment
- RNA and protein synthesis mechanisms
- Prostate Cancer Treatment and Research
- Cerebrovascular and Carotid Artery Diseases
- Lung Cancer Treatments and Mutations
- Circular RNAs in diseases
- Cancer-related gene regulation
- RNA Research and Splicing
- Immune cells in cancer
- CRISPR and Genetic Engineering
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gallbladder and Bile Duct Disorders
- Colorectal Cancer Screening and Detection
Yuhuangding Hospital
2016-2025
Second Affiliated Hospital of Zhejiang University
2010-2024
Zhejiang Chinese Medical University
2024
Hainan Branch of People's Liberation Army General Hospital
2024
Center for High Pressure Science & Technology Advanced Research
2022-2024
Fudan University Shanghai Cancer Center
2024
Zhejiang University
2006-2024
Institute of Automation
2024
Chinese Academy of Sciences
2012-2024
Southern Medical University
2021-2024
Mutant RAS has remained recalcitrant to targeted therapy efforts. We demonstrate that combined treatment with poly(adenosine diphosphate–ribose) polymerase (PARP) inhibitors and mitogen-activated protein kinase (MAPK) (MEK) evokes unanticipated, synergistic cytotoxic effects in vitro vivo multiple mutant tumor models across lineages where mutations are prevalent. The of PARP MEK inhibitor combinations independent BRCA1/2 p53 mutation status, suggesting the activity is likely be...
Abstract The limited supply of intracellular malonyl-CoA in Escherichia coli impedes the biological synthesis polyketides, flavonoids and biofuels. Here, a clustered regularly interspaced short palindromic repeats (CRISPR) interference system was constructed for fine-tuning central metabolic pathways to efficiently channel carbon flux toward malonyl-CoA. Using synthetic sgRNA silence candidate genes, genes that could increase level by over 223% were used as target genes. efficiencies...
The capacity of targeted anticancer agents to exert immunomodulatory effects provides a strong rationale develop novel suitable for combinatorial regimens with immunotherapy improve clinical outcomes. In this study, we developed dual-targeting PI3K and HDAC inhibitor BEBT-908 that potently inhibits tumor cell growth potentiates anti-PD1 therapy in mice by inducing immunogenic ferroptosis cancer cells. Treatment promoted ferroptotic death cells hyperacetylating p53 facilitating the expression...
The management of chronic wounds in diabetes remains challenging due to the complexity impaired wound healing, delayed susceptibility infection, and elevated risk reopening, highlighting need for effective with innovative approaches such as multifunctional hydrogels. Here, we have produced HA-DA@rhCol hydrogels consisting dopamine-modified hyaluronic acid recombinant human collagen type-III (rhCol) by oxidative coupling catechol group using H
Positron emission tomography (PET) with 18- fluorodeoxyglucose (FDG) has been used to both detect and stage a variety of malignancies. The current study examined the value PET for preoperative staging gastric adenocarcinoma.Sixty-eight patients (49 males 19 females) adenocarcinoma, who were referred FDG-PET scans, enrolled in this study. underwent spiral-computed (CT) within 1 week referral. final diagnosis all was made by histologic surgical findings. For quantitative analysis, regional...
Identifying new indications for existing drugs (drug repositioning) is an efficient way of maximizing their potential. Adverse drug reaction (ADR) one the leading causes death among hospitalized patients. As both and ADRs are caused by unexpected chemical-protein interactions on off-targets, it reasonable to predict these mining interactome (CPI). Making such predictions has recently been facilitated a web server named DRAR-CPI. This representative collection molecules targetable human...
Abstract Programmed cell death 1 ligand (PD-L1) is a key driver of tumor-mediated immune suppression, and targeting it with antibodies can induce therapeutic responses. Given the costs associated toxicity PD-L1 blockade, alternative strategies are needed. Using reverse-phase protein arrays to assess drugs in use or likely enter trials, we performed candidate drug screen for inhibitors expression identified verteporfin as possible small-molecule inhibitor. Verteporfin suppressed basal...
Increased mitochondrial reactive oxygen species (mROS) and glycolysis have been established in pulmonary hypertension (PH). However, the effect of elevated mROS on glycolytic shift how increased promotes hypoxic artery smooth muscle cell (PASMC) proliferation vascular remodeling remain elusive. Here, we reported that hypoxia-induced inhibit HIF-1α hydroxylation further trigger PASMC switch through upregulated HIF-1α/PDK1&PDK2/p-PDH-E1α axis, which facilitates lactate accumulation histone...
Abstract Background Chimeric antigen receptor (CAR) -T cell therapy is an efficient therapeutic strategy for specific hematologic malignancies. However, positive outcomes of this novel in treating solid tumors are curtailed by the immunosuppressive tumor microenvironment (TME), wherein signaling checkpoint programmed death-1 (PD-1)/PD-L1 directly inhibits T-cell responses. Although checkpoint-targeted immunotherapy succeeds increasing number T cells produced to control growth, desired effect...
OBJECTIVES: The prognosis of pancreatic cancer is still very poor, and the ability to detect in high-risk groups at an early stage therefore essential for improving its long-term survival. purpose this study was explore specific biomarkers that can differentiate cancer–associated diabetes from type 2 diabetes, detection cancer. METHODS: From January 2006 July 2008, 102 peripheral blood samples were collected 25 patients diagnosed with 27 without mellitus >5 years, healthy controls....
Colorectal cancer (CRC) is one of the most commonly diagnosed cancers with an estimated 1.8 million new cases worldwide and associated high mortality rates 881 000 CRC-related deaths in 2018. Screening programs therapies have only marginally improved survival CRC patients. Immune-related genes (IRGs) attracted attention recent years as therapeutic targets. The aim this study was to identify immune-related prognostic signature for CRC. To end, we combined gene expression clinical data from...
68Ga-labeled, low-molecular-weight imaging agents that target the prostate-specific membrane antigen (PSMA) are increasingly used clinically to detect prostate and other cancers with positron emission tomography (PET). The goal of this study was compare pharmacokinetics three PSMA-targeted radiotracers: 68Ga-1, using DOTA-monoamide as chelating agent; 68Ga-2, containing macrocyclic agent p-SCN-Bn-NOTA; 68Ga-DKFZ-PSMA-11, currently in clinical trials, which uses acyclic agent, HBED-CC....
ABSTRACT Background The 2019 novel coronavirus (COVID-19) has continuous outbreaks around the world. Lung is main organ that be involved. There a lack of clinical data on respiratory sounds COVID-19 infected pneumonia, which includes invaluable information concerning physiology and pathology. medical resources are insufficient, now mainly supplied for severe patients. development convenient effective screening method mild or asymptomatic suspicious patients highly demanded. Methods This...
Abstract Postoperative venous thromboembolic events (VTEs), such as lower extremity deep vein thrombosis (DVT), are major risk factors for gastric cancer (GC) patients following radical gastrectomy. Accurately predicting and managing these risks is crucial optimal patient care. This retrospective case‒control study involved 693 GC from our hospital who underwent We collected plentiful comprehensive clinical indicators including a total of 49 baseline, preoperative, surgical pathological...
This multicenter, randomized phase III trial evaluated the efficacy and safety of perioperative camrelizumab (an anti-PD-1 antibody) plus low-dose rivoceranib (a VEGFR-2 inhibitor) S-1 oxaliplatin (SOX) (SOXRC), high-dose SOX (SOXR), alone for locally advanced gastric or gastroesophageal junction (G/GEJ) adenocarcinoma.
Introduction: Factors that influence neonatal transfusions are poorly understood because of individual variations in birth conditions and maternal complications during pregnancy. This study aimed to establish models incorporate perinatal factors associated with the early prediction timely management infants require transfusion. Methods: Data were collected from electronic medical records. Infants categorized into non-transfusion, one transfusion, two transfusions, three four more than groups...
Background Septic shock is linked with high mortality and significant long-term morbidity in survivors. However, the specific role of neutrophils septic pathophysiology remains scarce recent research. Methods Peripheral blood immune cells from healthy donors patients were analyzed using single-cell RNA sequencing batch sequencing. We measured serum CD121b both donors. isolated exposed to either a recombinant protein or blocking antibody evaluate expression inflammatory factors. Additionally,...