A5037551529- Cancer Mechanisms and Therapy
- Lung Cancer Treatments and Mutations
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Drug Transport and Resistance Mechanisms
- Cancer Immunotherapy and Biomarkers
- Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Cancer, Lipids, and Metabolism
- Brain Metastases and Treatment
- Gastric Cancer Management and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Beetle Biology and Toxicology Studies
- Esophageal Cancer Research and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Moyamoya disease diagnosis and treatment
- Pediatric health and respiratory diseases
- Histone Deacetylase Inhibitors Research
- interferon and immune responses
- Neurological Complications and Syndromes
- Epigenetics and DNA Methylation
- Respiratory and Cough-Related Research
- Cancer therapeutics and mechanisms
- Autophagy in Disease and Therapy
- Cancer survivorship and care
First Affiliated Hospital of Guangzhou University of Chinese Medicine
2016-2025
Third Affiliated Hospital of Southern Medical University
2025
Guangzhou University
2022
Guangzhou Medical University
2020
First Affiliated Hospital of Guangzhou Medical University
2020
Abstract Background Cholangiocarcinoma refers to an epithelial cell malignancy with poor prognosis. Yinchenhao decoction (YCHD) showed positive effects on cancers, and associations between YCHD cholangiocarcinoma remain unclear. This study aimed screen out the effective active components of using network pharmacology, estimate their potential targets, pathways, as well delve into mechanisms treating cholangiocarcinoma. Methods By traditional Chinese medicine system pharmacology database...
384950 Background: Tislelizumab is a humanized immunoglobulin G4 anti-programmed cell death protein 1 (PD-1) monoclonal antibody (mAb). At the interim analysis (median follow-up, 10.0 months), RATIONALE-309 met its primary endpoint, as first-line tislelizumab + chemotherapy significantly improved PFS, assessed by an independent review committee (IRC), in patients with recurrent/metastatic nasopharyngeal cancer (RM NPC) compared placebo chemotherapy. had acceptable safety profile, comparable...
Previous studies showed that the female genital tract microbiome plays a crucial role in regulating host's immune defense mechanisms. Our previous research has shown Lactobacillus gasseri LGV03 (L. LGV03) isolated from cervico-vagina of HPV-cleared women contributes to clearance HPV infection and beneficially regulate response. However, mechanisms behind regulation L. response remain unclear. To better understand interaction between function, immunomodulatory activities were investigated...
Abstract Objective: We conducted this study to evaluate the efficacy and safety of traditional Chinese medicine (TCM) in advanced non-small cell lung cancer (NSCLC) patients who underwent chemotherapy. Design: This was a prospective, open-label, randomized controlled trial. NSCLC at stage IIIA, IIIB, or IV were randomly assigned either TCM plus chemotherapy alone. The comprehensive treatment consisted Kang Ai injection, herbal decoction, Zhenqifuzheng capsules. primary endpoint quality life...
Non-small cell lung cancer (NSCLC), which accounts for 85% of cases, calls better therapy. Yi-Fei-San-Jie-pill (YFSJ), a well-applicated traditional Chinese medicine formula, was reported to be effective in the treatment NSCLC. However, its anti-tumor mechanism still needs fully elucidated. Herein, reliable preclinical orthotopic but not subcutaneous model NSCLC mice established evaluate anti-cancer properties and further validate mechanisms YFSJ. A bioinformatic analysis executed identify...
Background: NOP2 nucleolar protein plays a crucial role in early embryo development and cell proliferation. The of human gastric adenocarcinoma has not been elucidated. In the present study, we aimed to examine expression levels dissected whether was associated with aggressive clinicopathological outcomes patients adenocarcinoma. Methods: Clinicopathological analysis performed Expression tested by immunohistochemistry staining quantitative RT-PCR. prognostic assessed univariate multivariate...
Lung cancer is the leading cause of cancer-related deaths worldwide. Bone a common metastatic site lung cancer, about 50% bone patients will experience skeletal related events (SREs). SREs not only seriously impact on quality life patients, but also shorten survival time. The treatment metastasis requires multi-disciplinary team (MDT) and development individualized plan. In order to standardize diagnosis in expert group MDT Committee Chinese Medical Doctor Association has developed consensus...
Abstract Rationale: Syncope caused by head and neck cancer (HNC) is rare. However, syncope tongue (TC) even rarer. In TC, tumor-mediated compression of the carotid sinus stimulation glossopharyngeal nerve. Patient concerns: this study, we report case a 48-year-old male patient who was diagnosed with advanced TC bilateral cervical lymph node metastasis. On third day admission, experienced recurrent hypotension bradycardia. Diagnoses: The well-differentiated squamous cell carcinoma along...
Various RNA viruses could lead to tumorigenesis. Since these belong different genera, they have evolved distinct mechanisms of tumorigenesis, with unique interactions among key oncoproteins, oncogenes and hosts factors. This article reviews the tumorigenic mechanism two well-known human tumor viruses, explores potential effects SARS-CoV-2, which is also an virus.
Background: Posterior reversible encephalopathy syndrome (PRES), a neurological disorder with an unknown aetiology, is characterised by visual impairment, headache, vomiting, seizures, and transient alterations in consciousness. Case report: We present the case of 49-year-old woman advanced cervical carcinoma who received second-line therapy oral anlotinib (12 mg, days 1–14, every 21 days) injectable tislelizumab (200 day 1, days). After 7 administration, she began experiencing symptoms...
Objective: To evaluate the safety and antitumor activity of envafolimab monotherapy in Chinese patients with advanced solid tumors. Methods: This open-label, multicenter phase I trial included dose escalation expansion phases. In phase, received subcutaneous 0.1, 0.3, 1.0, 2.5, 5.0 or 10.0 mg/kg once weekly (QW) following a modified "3+ 3" design. The was performed 2.5 cohorts. Results: At November 25, 2019, total 287 treatment. During no dose-limiting toxicities (DLT) observed. all cohorts,...
Background: Lung adenocarcinoma (LUAD) is the most common type of lung cancer. DNA repair genes (DRGs) important in The relationship between immune environment and expression levels DRGs LUAD remains unclear. purpose this study to assess clinical characteristics LUAD.Methods: Data 169 cases were obtained from cbioportal. RNA-seq data came Cancer Genome Atlas (TCGA) database. We collected Reactom database (KW0037, Reactom.org). 302 expressed each sample analyzed by hierarchical clustering...
Chloride intracellular channel 1 (CLIC1) plays an important role in the process of cell epithelial transport, and is also involved tumor invasion metastasis. Due to its aberrant expression cancer, mechanism action CLIC1 cancer has been carefully studied. In this study, we tried investigate relationship between lung adenocarcinoma (LUAD).The RNA-sequencing data clinical information were collected from genome altas (TCGA) database analyzed with R software. Paired t test Mann-Whitney U used...
Abstract Background This study aimed to screen out the effective active components of Yinchenhao decoction (YCHD) using network pharmacology, estimate their potential targets, pathways, as well delve into mechanisms on treating cholangiocarcinoma. Methods By traditional Chinese medicine system pharmacology database and analysis platform (TCMSP) literature review, major corresponding targets were estimated screened out. Using software Cytoscape 3.6.0, a visual was established YCHD Based...
Abstract Background: This study aimed to screen out the effective active components of Yinchenhao decoction (YCHD) using network pharmacology, estimate their potential targets, pathways, as well delve into mechanisms on treating cholangiocarcinoma. Methods: By traditional Chinese medicine system pharmacology database and analysis platform (TCMSP) literature review, major corresponding targets were estimated screened out. Using software Cytoscape 3.6.0, a visual was established YCHD Based...
MET gene is a proto-oncogene, which encodes protein with tyrosine kinase activity. After binding to its ligand, hepatocyte growth factor, can induce dimerization and activate downstream signaling pathways, plays crucial role in tumor formation metastasis. Savolitinib, as specific inhibitor (TKI) targeting MET, selectively inhibits the phosphorylation of significant inhibitory effect on tumors abnormalities. Based efficacy shown registration studies, savolitinib was approved for marketing...
Abstract In this study, we investigated the underlying mechanism of action methyl-cantharidimide (MCA), a cantharidin (CTD) analog, as an anticancer drug, in resistant cancer cells overexpressing either ABCB1 or ABCG2 and cisplatin-resistant cells. The results indicated that: (i) MCA was efficacious ABCB1-overexpressing cell line, KB-C2, ABCG2-overexpressing NCI-H460/MX20 cisplatin lines, KCP-4 BEL-7404/CP20; (ii) induced apoptosis both BEL-7404 BEL-7404/CP20 arrested G0/G1 phase cycle;...
Abstract Purpose: DNA damage repair (DDR) mutations are known to predict response platinum-based chemotherapy in multiple solid tumors, as well immunotherapy non-small cell lung cancer (NSCLC). However, the predictive value of DDR immunization combined with platinum remains unclear. Methods: We retrospectively collected information from 495 patients advanced NSCLC whose tumors were analyzed using next-generation sequencing (NGS) and characteristics mutations. Among them, 64 who received 37...
Abstract Background: Cholangiocarcinoma refers to an epithelial cell malignancy with poor prognosis. Yinchenhao decoction (YCHD) showed positive effects on cancers, and associations between YCHD cholangiocarcinoma remain unclear. This study aimed screen out the effective active components of using network pharmacology, estimate their potential targets, pathways, as well delve into mechanisms treating cholangiocarcinoma. Methods: By traditional Chinese medicine system pharmacology database...