A5100778870- Monoclonal and Polyclonal Antibodies Research
- Cancer-related molecular mechanisms research
- Gastric Cancer Management and Outcomes
- Metal complexes synthesis and properties
- Liver Disease Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- Autophagy in Disease and Therapy
- Sphingolipid Metabolism and Signaling
- Cancer therapeutics and mechanisms
- Trace Elements in Health
- Colorectal Cancer Surgical Treatments
- Epigenetics and DNA Methylation
- Gastrointestinal Tumor Research and Treatment
- Drug Transport and Resistance Mechanisms
- RNA modifications and cancer
- Advanced Biosensing Techniques and Applications
- Cancer Mechanisms and Therapy
- Lung Cancer Treatments and Mutations
- Molecular Biology Techniques and Applications
- Immune Cell Function and Interaction
- Cancer-related gene regulation
- Bacteriophages and microbial interactions
- Cancer, Lipids, and Metabolism
- Metastasis and carcinoma case studies
Xinxiang Medical University
2015-2025
Shandong First Medical University
2014-2025
Shandong Tumor Hospital
2014-2025
Hubei University
2025
China General Nuclear Power Corporation (China)
2024
Sun Yat-sen University
2018-2024
Zhengzhou University
2023-2024
The First Affiliated Hospital, Sun Yat-sen University
2023
Sun Yat-sen Memorial Hospital
2021-2022
Southern Medical University
2010-2019
It is well known that DNA damage can cause apoptosis. However, whether apoptosis and its metabolites contribute to repair largely unknown. In this study, we found apoptosis-deficient Fas
Chronic liver disease mediated by activation of hepatic stellate cells (HSCs) and Kupffer (KCs) leads to fibrosis. Here, we aimed investigate the molecular mechanism define cell type involved in mediating sphingosine kinase (SphK)1-dependent effect on The levels expression activity SphK1 were significantly increased fibrotic livers compared with normal human. was coexpressed a range HSC/KC markers including desmin, α-smooth muscle actin (α-SMA) F4/80 liver. Deficiency (SphK1-/- ) resulted...
In metastasis of cancer cells, the epithelial-mesenchymal transition (EMT) is prerequired. Ferroptosis an iron-mediated cellular death process, but whether it involves EMT regulation remains elusive. addition, how stress responders (Nrf2) respond to redox alteration and cross-talking between them needs be determined. Our data revealed that DpdtbA (2,2 <a:math xmlns:a="http://www.w3.org/1998/Math/MathML" id="M2"> <a:msup> <a:mrow/> <a:mrow> <a:mo>′</a:mo> </a:mrow> </a:msup> </a:math>...
Oxymatrine (OXY) has antioxidative and antiinflammatory activities. In the present work, we investigate effects of OXY on gastric ulcer models elucidate underlying mechanisms action. Ethanol, indometacin, restraint water immersion stress‐induced ulcerated were used. The area was measured, samples tissue taken for pathological, histochemical, biochemical analyses. effectively reduced ulcers improved pathological changes tissue. enhanced expression Bcl‐2, Bax protein expression, inhibited...
A novel strategy for the synthesis of 2-arylated oxazole derivatives <italic>via</italic> palladium/copper-catalyzed decarbonylative heteroarylation amides C–N bond activation by ground-state destabilization is reported.
Xylitol is a sugar–alcohol compound with broad applications in fields such as the food, dental, and pharmaceutical sectors. Although xylitol biosynthesis has gained attention, current strategy for industrial production majorly relies on chemical hydrogenation of xylose, which energy-intensive environmentally harmful. In this study, toxicity toward Escherichia coli was first examined, result demonstrated that robust against at 150 g/L. Genes encoding xylose reductases from different...
Background Gastric varices (GV) are life-threatening for patients with portal hypertension. Endoscopic injection butyl cyanoacrylate (BC), the mainstay of therapy GV, has been reported to be effective hemostasis bleeding varices, but its efficacy in obliteration GV and impact on survival still needs clarification. Here we summarized our experience 10 years' practice evaluate safety endoscopic using BC patients. Methods From January 1997 April 2006, cases treated were collected. The "sandwich...
The primary aim of this research was to investigate the association between uridine diphosphate glucuronosyltransferase (UGT)1A1 gene polymorphisms and toxicities irinotecan-based regimens in Chinese patients with metastatic colorectal cancer.The study analyzed distribution UGT1A1*28/*6 by polymerase chain reaction amplification pyrosequencing. adverse reactions tumor response were evaluated according National Cancer Institute Common Toxicity Criteria for Adverse Events, Version 3.0,...
Matrix attachment regions (MARs) are cis-acting DNA elements that can increase transgene expression levels in a CHO cell system. To investigate the effects of MAR combinations on and underlying regulatory mechanisms, we generated constructs which enhanced green fluorescent protein (eGFP) gene flanked by different human β-interferon β-globin (iMAR gMAR, respectively), was driven cytomegalovirus (CMV) or simian virus (SV) 40 promoter. These were transfected into CHO-K1 cells, screened with...
Epithelial-mesenchymal transition (EMT) involves metastasis and drug resistance; thus, a new EMT reversing agent is required. It has shown that wild-type p53 can reverse back to epithelial characteristics, iron chelator acting as inducer been demonstrated. Moreover, recent study revealed etoposide could also inhibit EMT. Therefore, combination of with might achieve better inhibition To this end, we prepared di-2-pyridineketone hydrazone dithiocarbamate S-propionate podophyllotoxin ester...
Abnormal activation of protein kinases and phosphatases is implicated in various tumorigenesis, including hepatocellular carcinoma (HCC). Advanced HCC patients are treated with systemic therapy, tyrosine kinase inhibitors, which extend overall survival. Investigation the underlying mechanism signaling will help to improve efficacy therapy. Combining single-cell RNA sequencing data TCGA RNA-seq data, we profiled kinases, phosphatases, other phosphorylation-related genes (PRGs) this study. We...
Abnormalities of brain energy metabolism are involved in Alzheimer disease (AD). Sirtuin 1 (SIRT1) is a class III histone deacetylase and activates peroxisome proliferator-activated receptor-γ co-activator-1α (PGC-1α), which enhances mitochondrial biogenesis homeostasis. Electroacupuncture (EA) has been reported to improve AD. However, the effect EA on SIRT1 PGC-1α AD remains unclear.ATP levels were measured using assay kits hippocampus frontal cortex senescence-accelerated mouse prone 8...
The bone marrow niche plays a critical role in controlling the fate of hematopoietic stem cells (HSCs) by integrating intrinsic and extrinsic signals. However, molecular events HSC remain to be investigated. Here, we report that intercellular adhesion molecule-1 (ICAM-1) maintains quiescence repopulation capacity niche. ICAM-1-deficient mice (ICAM-1−/−) displayed significant expansion phenotypic long-term HSCs with impaired quiescence, as well favoring myeloid cell expansion. presented...
Hepatocellular carcinoma (HCC) has a poor prognosis due to the rapid disease progression and early metastasis. The metabolism program determines proliferation metastasis of HCC; however, metabolic approach treat HCC remains uncovered. Here, by analyzing liver cell single-cell sequencing data from patients healthy individuals, we found that 6-phosphogluconolactonase (PGLS), cytosolic enzyme in oxidative phase pentose phosphate pathway (PPP), expressing cells are associated with...