A5100332892- Glioma Diagnosis and Treatment
- Mesenchymal stem cell research
- Chronic Lymphocytic Leukemia Research
- GaN-based semiconductor devices and materials
- Parathyroid Disorders and Treatments
- Dialysis and Renal Disease Management
- Liver physiology and pathology
- Radical Photochemical Reactions
- Lymphoma Diagnosis and Treatment
- Tissue Engineering and Regenerative Medicine
- Eicosanoids and Hypertension Pharmacology
- Hormonal Regulation and Hypertension
- Blood Pressure and Hypertension Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Neurofibromatosis and Schwannoma Cases
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cancer Immunotherapy and Biomarkers
- Cardiovascular Function and Risk Factors
- Organ Transplantation Techniques and Outcomes
- Liver Disease Diagnosis and Treatment
- ZnO doping and properties
- Research in Cotton Cultivation
- Extracellular vesicles in disease
- Semiconductor materials and devices
- Immunodeficiency and Autoimmune Disorders
Sun Yat-sen Memorial Hospital
2016-2025
Nanchang University
2018-2025
Dana-Farber Cancer Institute
2014-2024
Boston Medical Center
2024
University Medical Center
2024
Boston University
2024
Sun Yat-sen University
2015-2024
Washington University in St. Louis
2022-2024
University of South China
2024
Memorial
2024
CXCR4(WHIM) somatic mutations are distinctive to Waldenström Macroglobulinaemia (WM), and impact disease presentation treatment outcome. The clonal architecture of remains be delineated. We developed highly sensitive allele-specific polymerase chain reaction (AS-PCR) assays for detecting the most common (CXCR4(S338X C>A C>G) ) in WM. AS-PCR detected CXCR4(S338X) WM IgM monoclonal gammopathy unknown significance (MGUS) patients not revealed by Sanger sequencing. By combined sequencing, were...
Summary CXCR 4 WHIM frameshift and nonsense mutations follow MYD 88 L265P as the most common somatic variants in W aldenström M acroglobulinaemia ( WM ), impact clinical presentation ibrutinib response. While S338X ) mutation has been investigated, little is known about FS mutations. We engineered cells to express present patients, compared their CXCL 12 SDF ‐1a) induced signalling sensitivity wild‐type (WT) cells. Following stimulation, showed impaired receptor internalization, enhanced AKT...
Abstract A visible light photosensitizing metal‐organic cage is applied as an artificial supramolecular reactor to control the reaction of aryl radicals with terminal olefins under green light/solvent conditions, which facilitates selective transformation in confined enzyme‐mimicking environment give a series geometrically defined E / Z ‐alkenes. The hydrophobic displays good host–guest inclusion aromatic substrates, promoting Meerwein arylation and protecting ‐isomeric products during...
This study was designed to determine the optimal time point for bone marrow mesenchymal stem cell (MSC) transplantation after myocardial infarction (MI).MSCs from donor rats were labeled with DAPI before transplantation. The animals underwent MI by ligation of left anterior descending coronary artery, and received intramyocardial injection MSCs at 1h, 1 week 2 weeks MI, respectively. Sham-operated control groups equal volume phosphate buffered saline. Cardiac function, histological analysis...
Vascular calcification (VC) is an important predictor of cardiovascular morbidity and mortality. Osteogenic differentiation vascular smooth muscle cells (VSMCs) a key mechanism VC. Recent studies show that IL-18 (interleukin-18) favors VC while TRPM7 (transient receptor potential melastatin 7) channel upregulation inhibits However, the relationship between unclear. We questioned whether enhances osteogenic VSMCs through activation.Coronary artery serum were measured in patients by computed...
Accumulating evidence has indicated that the stromal cell-derived factor-1 (SDF-1)/CXC chemokine receptor 4 (CXCR4) axis plays a crucial role in recruitment of bone marrow-derived mesenchymal stem cells (BMSCs) into lesion sites animal models. The aim this study was to investigate effects SDF-1/CXCR4 on migration transplanted BMSCs mobilized by erythropoietin (EPO) toward site following spinal cord injury (SCI). A model SCI established rats using modified Allen's test. In EPO group,...
Abstract Background and Aim: Lymph node metastasis is a major prognostic factor for perihilar cholangiocarcinoma (PHC). However, significance of extent dissection, lymph ratio (LNR), number location positive nodes remain unclear. We aimed to evaluate whether status, LNR, or are independent factors staging in PHC determine the minimum requirements examination. Methods: The Surveillance, Epidemiology, End Results database was used identify 1116 resected PHCs from 1998 2008. correlation between...
Abstract A convenient and efficient synthesis of sulfones from sulfinates aryl halides was developed. The reaction occurred under UV irradiation without transition metal catalyst or photocatalyst. radical pathway via single‐electron transfer (SET) electron donor‐acceptor (EDA) complex proposed based on UV‐vis spectroscopy, inhibiting trapping experiments. magnified image
An enantioselective conjugate addition of ethylene sulfonyl fluorides to 3-amido-2-oxindoles has been developed. Quinine-derived squaramides were identified as efficient catalysts. A series spirocyclic oxindole sultams prepared with excellent yields and enantioselectivities. reaction mechanism via bifunctional activation was proposed.
Abstract Distant metastasis is one of the leading causes cancer-related mortality colorectal cancer (CRC). Dysregulation E3 ubiquitin ligases has been implicated in acting vital roles multiple cancers. In this study, we found that ligase, PRPF19 was positively correlated with liver metastasis, and predicted a worse clinical outcome CRC. However, biological effects underlying molecular mechanisms CRC remain elusive thus far. We illustrated promoted migration invasion capability cells both...
The permanent magnet motor in the three-stage has significant technical advantages ultra-high-speed field with poor working environment due to its high power density and structure. However, it is difficult for adjust magnetic control output voltage, voltage regulation circuit main generator GCU needs +12V, -12V other multi-channel isolated voltages of different levels. At present, topology suitable step-down supply flyback conversion topology. switch tube ordinary cannot achieve soft...
Short chain fatty acids acetate and propionate have been demonstrated protective function in the intestinal mucosa. However, their impact on gastric mucosa has not yet elucidated. The current study aimed to investigate potential effects of against ethanol-induced mucosal lesion underlying mechanism mice. ICR mice were orally treated with propionate, respectively, 30 min prior establishment injury model by challenge absolute ethanol. samples collected for detection oxidative, inflammatory...