A5084056086- Immune Cell Function and Interaction
- Hematopoietic Stem Cell Transplantation
- Ubiquitin and proteasome pathways
- Cancer, Hypoxia, and Metabolism
- Galectins and Cancer Biology
- Protein Tyrosine Phosphatases
- Lipid metabolism and disorders
- Histone Deacetylase Inhibitors Research
- Cancer-related gene regulation
- Acute Myeloid Leukemia Research
- Cancer-related Molecular Pathways
- Peptidase Inhibition and Analysis
- Immune cells in cancer
- Mesenchymal stem cell research
- Protein Degradation and Inhibitors
- Stress Responses and Cortisol
- Angiogenesis and VEGF in Cancer
- Retinoids in leukemia and cellular processes
- Cancer-related molecular mechanisms research
- Mitochondrial Function and Pathology
- T-cell and B-cell Immunology
- Neuroendocrine regulation and behavior
- Tryptophan and brain disorders
- Peroxisome Proliferator-Activated Receptors
- Sphingolipid Metabolism and Signaling
University of Missouri
2016-2025
University of Missouri Health System
2024
University of Missouri Hospital
2021-2023
The University of Texas Southwestern Medical Center
2012-2018
Shanghai Jiao Tong University
2007-2016
Institute of Developmental Physiology
2014
State Key Laboratory of Oncogene and Related Genes
2010
Shanghai Cancer Institute
2010
Shanghai Municipal Education Commission
2010
Brown Foundation
2007
SENP1 (SUMO-specific protease 1) has been shown to be essential for the stability and activity of hypoxia-inducible factor 1 (HIF-1α) under hypoxia conditions. However, it is unknown how activation signaling are coordinated in cellular response hypoxia. Here, we report role endothelial cells as a positive regulator hypoxia-driven VEGF production angiogenesis. expression increased following exposure Silencing HIF-1α blocks cell Mutation element (HRE) on Senp1 promoter abolishes its...
Cell cycle quiescence is critical for hematopoietic stem cell (HSC) maintenance. TGF-β signaling in bone marrow niche has been identified regulating HSC quiescence; however, the intrinsic regulatory mechanisms remain unclear. This study reports that Shp-1 knockout HSCs have attenuated and impaired long-term self-renewal. SHP-1–activated are surrounded by megakaryocytes, which regulate producing TGF-β1. Mechanistically, SHP-1 interacts with immunoreceptor tyrosine-based inhibition motif on...
Chemotherapy-related cognitive impairment (CRCI) significantly impacts cancer survivors. Due to unclear mechanisms, effective treatments for deficits are lacking. Here, we examined if microglia-mediated in synaptic plasticity drive CRCI. Adult male mice were treated with the chemotherapeutic drugs 5-fluorouracil and leucovorin (5-Fu/LV, intraperitoneal injection, I.P.) on Days 1, 8, 15 at a dosage of 50 mg/kg 5-Fu 90 LV 3 weeks. Cognitive function was assessed using novel object recognition...
We recently identified the human leukocyte immunoglobulin-like receptor B2 (LILRB2) and its mouse ortholog-paired Ig-like (PirB) as receptors for several angiopoietin-like proteins (Angptls). also demonstrated that PirB is important development of acute myeloid leukemia (AML), but exactly how an inhibitory such can support cancer intriguing. Here, we showed activation Ca (2+)/calmodulin-dependent protein kinases (CAMKs) coupled with signaling in AML cells. High expression CAMKs associated a...
Leukemic-stem-cell-specific targeting may improve the survival of patients with acute myeloid leukemia (AML) by avoiding ablative effects standard regimens on normal hematopoiesis. Herein, we perform an unbiased screening compounds cell surface proteins and identify clinically used DPP4 inhibitors as strong suppressors AML development in both murine models primary human cells xenograft model. We find retrovirus-induced mouse that DPP4-deficient cell-transplanted mice exhibit delay reversal...
// Baijun Dong 1, * , Yujing Gao 2, Xunlei Kang 3, Hongchang 4, Jin Zhang 1 Hua Guo 5, 7 Mingjian J You 6 Wei Xue Jinke Cheng 3 Yiran Huang Department of Urology, School Medicine, Renji Hospital, Shanghai Jiao Tong University, Shanghai, China 2 Key Laboratory Fertility Preservation and Maintenance Ministry Education, Biochemistry Molecular Biology, Ningxia Medical Yinchuan, Ningxia, Cell University 4 Pharmacy, Wenzhou College, Wenzhou, 5 Hematopathology, Texas MD Anderson Cancer Center,...
Corticotropin-releasing hormone (CRH) is a neuropeptide regulating neuroendocrine and autonomic function. CRH mRNA protein levels in the hypothalamic paraventricular nucleus (PVN) are increased primary hypertension. However, role of elevated sympathetic outflow hypertension remains unclear. CRHR1 proteins were distributed retrogradely labeled PVN presympathetic neurons with an level tissue adult spontaneously hypertensive rats (SHRs) compared age-matched male Wistar–Kyoto (WKY) rats. induced...
Patients with prostate cancer (PCa) have a variable prognosis. It is challenging to recognize the progressive disease. In this study, we focused on TSPAN1, new member of tetraspanin family. Its expression was decreased in PCa and an independent prognosis factor biochemical recurrence after radical prostatectomy. vitro, knockdown overexpression TSPAN1 cell lines showed that could inhibit proliferation migration. positive related PTEN both clinical specimen mouse models. The combination these...
BackgroundChromosomal translocation-induced expression of the chromatin modifying oncofusion protein MLL-AF9 promotes acute myelocytic leukemia (AML). Whereas WNT/β-catenin signaling has previously been shown to support MLL-AF9-driven leukemogenesis, mechanism underlying this relationship remains unclear.MethodsWe used two novel small molecules targeting WNT as well a genetically modified mouse model that allow targeted deletion chaperone Wntless (WLS) evaluate role in AML progression....