A5079216284- Metal complexes synthesis and properties
- Ferrocene Chemistry and Applications
- Synthesis and Characterization of Heterocyclic Compounds
- Nanocluster Synthesis and Applications
- Gold and Silver Nanoparticles Synthesis and Applications
- Autophagy in Disease and Therapy
- Synthesis of Tetrazole Derivatives
- Quinazolinone synthesis and applications
- Advanced Nanomaterials in Catalysis
- Click Chemistry and Applications
- Nanoparticle-Based Drug Delivery
- Synthesis and biological activity
- Natural product bioactivities and synthesis
- Mesenchymal stem cell research
- Fungal Plant Pathogen Control
- Genetic factors in colorectal cancer
- Machine Learning in Bioinformatics
- Spinal Cord Injury Research
- Hematopoietic Stem Cell Transplantation
- Biological and pharmacological studies of plants
- Hepatitis B Virus Studies
- Advanced Synthetic Organic Chemistry
- Aortic aneurysm repair treatments
- Nanoplatforms for cancer theranostics
- Inflammatory Biomarkers in Disease Prognosis
South China University of Technology
2020-2023
Beijing Anzhen Hospital
2023
Capital Medical University
2023
Jiangsu University of Science and Technology
2019-2022
Hubei University of Medicine
2015-2021
University Hospital Münster
2019
Guangdong Pharmaceutical University
2016-2018
A precise understanding of nano-bio interactions in the sub-nanometer regime is necessary for advancements nanomedicine. However, this currently hindered by control nanoparticle size regime. Herein, we report a facile situ Mn2+ -guided centrifugation strategy synthesis large-scale ultrasmall gold nanoparticles (AuNPs) with precisely controlled gradient at With discovery that [Mn(OH)]+ , especially metallic manganese (Mn0 @[Mn(OH)]+ ) nanoparticles, could selectively interact larger AuNPs...
Accumulating evidence has indicated that the stromal cell-derived factor-1 (SDF-1)/CXC chemokine receptor 4 (CXCR4) axis plays a crucial role in recruitment of bone marrow-derived mesenchymal stem cells (BMSCs) into lesion sites animal models. The aim this study was to investigate effects SDF-1/CXCR4 on migration transplanted BMSCs mobilized by erythropoietin (EPO) toward site following spinal cord injury (SCI). A model SCI established rats using modified Allen's test. In EPO group,...
The nanoprobes for identification of cancer metastases in the mononuclear phagocyte system (MPS) organs are significant importance but limited due to long-standing challenge low tumor-targeting specificity with inadequate targeting efficiency and high nonspecific accumulation. Here, we report a surface regulation strategy that integrates tumor-acidity-activated charge-reversal behavior precise control both hydrodynamic diameter (HD) charge on ultrasmall luminescent gold nanoparticles (AuNPs)...
This study explored the prognostic role of GPR27 and its predictive value to platinum-based therapy in ovarian cancer. A survival analysis GPR27, therapeutic response platinum cancer was investigated using data from genome atlas (TCGA) Gene Expression Omnibus (GEO) databases. expression assessed reverse transcription-polymerase chain reaction (RT-PCR) immunohistochemistry. Database RT-PCR revealed over-expression mRNA tissues compared normal tissues. Ovarian patients with up-regulated...
The construction of luminescent gold nanoparticles (AuNPs) with highly redshifted emission in the second near-infrared window (NIR-II) and good biocompatibility is still challenging. Herein, using an amphiphilic block copolymer (ABC) template controllable hydrophobic interactions diverse forms unimers micelles, we report a facile strategy for redshifting enhancing biological AuNPs. While uniform clusters NIR-II AuNPs are formed situ inside cores ABC micelles strong interparticle enhanced at...
Cancer Biotherapy and Radiopharmaceuticals officially retracts the paper entitled, "miR-155 Affects Osteosarcoma MG-63 Cell Autophagy Induced by Adriamycin Through Regulating PTEN-I3K/AKT/mTOR Signaling Pathway" Lin Wang, Bing Tang, Heng Han, Dan Mao, Jie Chen, Yun Zeng, Min Xiong (Cancer Biother Radiopharm 2018;33(1):32–38; doi: 10.1089/cbr.2017.2306) due to discovery that was submitted from a mill, which is violation of journal's standard protocols. The Editor Publisher are committed...
Three new Ru(<sc>ii</sc>) complexes [Ru(N–N)<sub>2</sub>(PTCP)]<sup>2+</sup> were synthesized and characterized. The DNA-binding, <italic>in vitro</italic> cytotoxicity, apoptosis, autophagy western blot analysis investigated.
A new iridium(<sc>iii</sc>) complex, Ir(ppy)<sub>2</sub>(FBPIP)]PF<sub>6</sub> (<bold>Ir-1</bold>), was synthesized and characterized. The anticancer activity of the complex investigated by cytotoxicity <italic>in vitro</italic>, apoptosis, cell invasion, autophagy, cycle arrest western blot.
Four new ruthenium(<sc>ii</sc>) polypyridyl complexes were synthesized and characterized. The anticancer activity was investigated by cytotoxicity <italic>in vitro</italic>, apoptosis, comet assay, ROS, autophagy, cell invasion western blot analysis.
In this work, a total of 19 novel naphthalene hybrids with chimonanthine scaffolds were efficiently synthesised from indole-3-acetonitrile in good yields. The prepared compounds evaluated for biological activity against Cryptococcus neoformans, Escherichia coli, Shigella spp, Candida albicans, Salmonella and Staphylococcus aureus. preliminary bioassays showed that most the exhibited significant antibacterial or antifungal activity. Notably, compound 8 potent neofonmans, albicans than...
BACKGROUND Spinal cord injury (SCI) causes a rapid loss of motor neurons, leading to weakness and paralysis. Transplantation neural stem cells is known restore the neuronal activity but inefficient due limited regenerative capability low rate survival. There has been an emphasis on use growth factors along with (NSCs) enhance recovery. recombinant NSCs vascular endothelial factor (VEGF) might promote repair. This effect be attributed reduced transient receptor potential vanilloid 1 (TRPV1)...
Starting from indole-3-acetonitrile, a total of 66 new calycanthaceous alkaloid analogues were synthesised in excellent yields. The prepared compounds evaluated for their biological activities against broad range plant pathogen fungi. results bioassays indicated that the majority tested displayed comparable or better vitro bioactivities than positive control. Notably, Compound a1 significant B. cereus, Escherichia sp and R. solanacearum, even control streptomycin Penicillin, with same MIC...