A5075339326- RNA modifications and cancer
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Ferroptosis and cancer prognosis
- Lung Cancer Treatments and Mutations
- Colorectal Cancer Treatments and Studies
- Pancreatic and Hepatic Oncology Research
- RNA and protein synthesis mechanisms
- Genomics, phytochemicals, and oxidative stress
- Advanced Numerical Analysis Techniques
- Gastric Cancer Management and Outcomes
- Cancer Mechanisms and Therapy
- Gear and Bearing Dynamics Analysis
- Genetic factors in colorectal cancer
- Metallurgical Processes and Thermodynamics
- Autophagy in Disease and Therapy
- Epigenetics and DNA Methylation
- Cell death mechanisms and regulation
- Metal Alloys Wear and Properties
- Hepatocellular Carcinoma Treatment and Prognosis
- FOXO transcription factor regulation
- Infrastructure Maintenance and Monitoring
- Gastrointestinal Tumor Research and Treatment
- Railway Engineering and Dynamics
Qingdao University
2015-2025
Affiliated Hospital of Qingdao University
2015-2025
Chongqing Medical University
2021-2023
Shaoguan University
2022
Baogang Group (China)
2021
Central South University
2014-2018
Guangzhou Railway Polytechnic
2018
Guangzhou Automobile Group (China)
2018
Northeast Ohio Medical University
1994
Ohio University
1994
Ferroptosis is a regulated cell death nexus linking metabolism, redox biology and diseases including cancer. The aim of the present study was to identify ferroptosis-related gene prognostic signature for stomach adenocarcinoma (STAD) by systematic analysis transcriptional profiles from Cancer Genome Atlas (TCGA), GEO clinical cohort our centre. We developed predictive model based on three genes (CHAC1, NOX4 HIF1A), expression data corresponding outcomes were obtained TCGA database,...
The mixed lineage kinase domain-like protein has recently been identified as a key downstream component of tumor necrosis factor-induced necroptosis, which is an important pathway cancer cell death. goal the current study to explore expression in colon tissues and evaluate prognostic value patients with cancer.We collected normal from 135 diagnosed after radical operation during July 2007 April 2009 at Affiliated Hospital Qingdao University. Immunohistochemistry analysis was scored using...
Background The process of human aging is accompanied by an increased susceptibility to various cancers, including gastric cancer. This heightened linked the shared molecular characteristics between and tumorigenesis. Autophagy considered a critical mediator connecting cancer, exerting dynamic regulatory effect in conjunction with cellular senescence during tumor progression. In this study, combined analysis autophagy- senescence-related genes was employed comprehensively capture...
Previous studies have demonstrated the preclinical pharmacological and toxicological consistency, clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference (Avastin). This randomized controlled trial aimed to compare efficacy safety Avastin in first-line treatment Chinese patients advanced or recurrent non-squamous non-small cell lung cancer (NSCLC).Stage IIIB-IV NSCLC evaluable lesions, good physical status, adequate organ functions from 67 centers across China...
Ferroptosis is a form of programmed cell death that participates in diverse physiological processes. Increasing evidence suggests long noncoding RNAs (lncRNAs) regulate ferroptosis tumors, including stomach adenocarcinoma (STAD). In the present study, RNA‑sequencing data from The Cancer Genome Atlas database and ferroptosis‑related markers FerrDb resource were analyzed to select differentially expressed lncRNAs. Univariate multivariate Cox regression analyses performed on these lncRNAs...
Background NPM, TFF3 and TACC1 are molecular markers that play important roles in cell differentiation. Herein, we investigated their prognostic impact patients with primary gastric cancer (GC) determined whether they could be used as of more aggressive carcinomas by detecting the extent expression human carcinoma samples. Methodology/Principal Findings Tumor tissue specimens from 142 GC were retrospectively retrieved immunohistochemically evaluated. Correlations between over-expression...
Background/Aims: Previous studies have shown that FOXO3, a member of the forkhead box O (FOXO) family, regulates autophagy in various cells. To date, whether induction gastric cancer (GC) cells is triggered by an acidic microenvironment unclear. Little known about relationship between FOXO3 and microenvironments GC. The aims our study were to investigate roles determine how regulate GC cell growth through autophagy. Methods: We cultured human adenocarcinoma (AGS) media with different pH...
Background: Forkhead box K1 (FOXK1) is a transcription factor belonging to the (FOX) family and closely related development of various cancers, but functional mechanism through which FOXK1 regulates autophagy epithelial-mesenchymal transition (EMT) in acidic microenvironment gastric cancer (GC) remains unclear.Results: Our results indicated that inhibition induced thus exerted antimetastatic effects an microenvironment.The dual mammalian target rapamycin (mTOR) enhanced reversed EMT GC...
Abstract Background Studies on various thrombopoietic agents for cancer treatment–induced thrombocytopenia (CTIT) in China are lacking. This study aimed to provide detailed clinical profiles understand the outcomes and safety of different CTIT treatment regimens. Methods In this retrospective, cross‐sectional study, 1664 questionnaires were collected from 33 hospitals between March 1 July 1, 2021. Patients aged >18 years enrolled who diagnosed with treated recombinant interleukin 11...
Abstract Most TRIM family members characterized by the E3-ubiquitin ligases, participate in ubiquitination and tumorigenesis. While there is a dearth of comprehensive investigation for entire gastric cancer (GC). By combining TCGA GEO databases, common (TRIMs) were obtained to investigate gene expression, mutations, clinical prognosis. On basis TRIMs, consensus clustering analysis was conducted, risk assessment system prognostic model developed. Particularly, TRIM31 with diagnostic value...
2514 Background: To explore the safety and synergistic anti-tumor effect of fruquintinib (a VEGFR inhibitor) in combination with sintilimab (an anti-PD-1 Ab) patients (pts) advanced colorectal cancer (CRC) other solid tumors. Methods: This is an ongoing phase Ib/II, multicenter, two-stage study. Pts variety types, including CRC, were enrolled continuously enrolling For this interim analysis, all pts analyzed for whereas only CRC efficacy. MMR status pts. Stage 1 was classical “3+3” dose...
Background and Aims: Base editing has shown great potential for treating human diseases with mutated genes. However, its HCC not yet been explored. Approach Results: We employed adenine base editors (ABEs) to correct a telomerase reverse transcriptase ( TERT ) promoter mutation, which frequently occurs in various cancers, including HCC. The −124 C>T is corrected C by single guide (sg) RNA-guided deactivated Campylobacter jejuni Cas9 (CjCas9)-fused editor (CjABE). This edit impairs the...
The design and integration of suspension parameters directly affects the riding quality a rail vehicle. This study is intended to develop an approach optimization vehicles based on virtual prototype Kriging model. To construct model, model vehicle its system was established vertical for dynamics using software. A also proposed, in which training sample obtained as different combinations simulations experiments method. On this basis, established, objective function index. optimized...
Gastric cancer has become a serious disease in the past decade. It second highest mortality rate among four most common types, leading to ~700,000 mortalities annually. Previous studies have attempted elucidate underlying biological mechanisms of gastric cancer. The present study aimed obtain useful biomarkers and improve understanding at genetic level. used bioinformatics analysis identify 1,829 differentially expressed genes (DEGs) which were obtained from GSE54129 dataset. Using...
Gastric cancer is one of the most common malignancies worldwide. Although diagnosis and treatment this disease have substantially improved in recent years, five-year survival rate gastric still low due to local recurrence distant metastasis. An in-depth study molecular pathogenesis related prognostic markers will help improve quality life prognosis patients with disease. The purpose was identify verify key SNPs genes value for cancer.SNP-related data from were obtained Cancer Genome Atlas...
Abstract Effective drugs for the treatment of gastric cancer (GC) are still lacking. Nortriptyline Hydrochloride (NTP), a commonly used antidepressant medication, has been demonstrated by numerous studies to have antitumor effects. This study first validated ability NTP inhibit GC and preliminarily explored its underlying mechanism. To begin with, inhibits activity AGS HGC27 cells (Human-derived cells) in dose-dependent manner, as well proliferation, cell cycle, migration. Moreover, induces...