A5101597458- Lung Cancer Treatments and Mutations
- Inhalation and Respiratory Drug Delivery
- Obstructive Sleep Apnea Research
- Cancer Immunotherapy and Biomarkers
- Cell death mechanisms and regulation
- Lung Cancer Research Studies
- Respiratory viral infections research
- Advanced Biosensing Techniques and Applications
- Biosensors and Analytical Detection
- Pneumonia and Respiratory Infections
- Eosinophilic Esophagitis
- Renal and related cancers
- Traditional Chinese Medicine Studies
- Sleep and related disorders
- Gastric Cancer Management and Outcomes
- Genetic and Kidney Cyst Diseases
- IL-33, ST2, and ILC Pathways
- Traditional Chinese Medicine Analysis
- Neuroscience of respiration and sleep
- Protein Kinase Regulation and GTPase Signaling
- Pediatric health and respiratory diseases
- Pancreatic and Hepatic Oncology Research
- Immune responses and vaccinations
- Telomeres, Telomerase, and Senescence
- Tuberculosis Research and Epidemiology
The University of Texas Southwestern Medical Center
2007-2024
People's Hospital of Xinjiang Uygur Autonomous Region
2014-2024
Huaian First People’s Hospital
2024
Mayo Clinic in Arizona
2019-2023
Lingnan Normal University
2023
Stone Clinic
2021
Mayo Clinic
2020
Bayer (China)
2016-2018
Xinjiang Medical University
2016
Harbin Medical University
2014
Importance For patients with non–small cell lung cancer whose disease progressed while receiving EGFR tyrosine kinase inhibitor (EGFR-TKI) therapy, particularly third-generation TKIs, optimal treatment options remain limited. Objective To compare the efficacy of ivonescimab plus chemotherapy alone for relapsed advanced or metastatic epidermal growth factor receptor ( ) variant. Design, Setting, and Participants Double-blind, placebo-controlled, randomized, phase 3 trial at 55 sites in China...
Renal microangiopathies and membranoproliferative GN (MPGN) can manifest similar clinical presentations histology, suggesting the possibility of a common underlying mechanism in some cases. Here, we performed homozygosity mapping whole exome sequencing Turkish consanguineous family identified DGKE gene variants as cause membranoproliferative-like glomerular microangiopathy. Furthermore, two additional cohort 142 unrelated patients diagnosed with GN. This encodes diacylglycerol kinase DGKε,...
Acute kidney injury (AKI) is a common clinical condition of growing incidence. Patients who suffer severe AKI have higher risk developing interstitial fibrosis, chronic disease, and end-stage renal disease later in life. Cellular senescence persistent cell cycle arrest altered gene expression pattern evoked by multiple stressors. The number senescent cells increases with age even small numbers these can induce inflammation fibrosis; indeed, organs including kidneys, the accumulation such...
Obstructive sleep apnea-hypopnea syndrome (OSAHS) is a complex chronic inflammatory respiratory disease with multiple pathogenic factors and high morbidity mortality. Serum levels of nuclear factor-κB (NF-κB), hypoxia-inducible factor-1 alpha (HIF-1α), surfactant protein D (SPD) were investigated in OSAHS patients, to determine their clinical significance correlation the pathogenesis. Patients classified into mild moderate group (n = 25) severe 33). Twenty healthy patients served as control...
Article6 December 2018Open Access Transparent process Prominin-1 controls stem cell activation by orchestrating ciliary dynamics Donald Singer Peninsula Dental School, University of Plymouth, UK Search for more papers this author Kristina Thamm Tissue Engineering Laboratories, Biotechnology Center and Molecular Cellular Bioengineering, Technische Universität Dresden, Germany Heng Zhuang Department Cariology, Endodontology Operative Dentistry, Peking School Hospital Stomatology, Beijing,...
We have previously shown that protein kinase Cϵ (PKCϵ) protects breast cancer cells from tumor necrosis factor-α (TNF)-induced cell death. In the present study, we investigated if antiapoptotic function of PKCϵ is mediated via Akt and mechanism by which regulates activity. TNF caused a transient increase in phosphorylation at Ser473 MCF-7 cells. Overexpression increased TNF-induced resulting its activation. Knockdown small interfering RNA (siRNA) decreased phosphorylation/activation...
Randomized clinical trials (RCTs) of PCSK9 monoclonal antibody(mAb) specifically for Chinese patients have been limited. This multi-center RCT is to clarify the efficacy and safety a novel mAb, Ebronucimab, in patients. Patients diagnosed with primary hypercholesterolemia, including Heterozygous Familial Hypercholesterolemia, or mixed dyslipidemia, were categorized by ASCVD risk randomly assigned at ratio 2:1:2:1 receive Ebronucimab 450 mg matching placebo every 4 weeks (Q4W), 150 2 (Q2W)....
Several novel protein kinase C (PKC) isozymes have been identified as substrates for caspase-3. We previously shown that PKCepsilon is cleaved during apoptosis in MCF-7 cells lack any functional In the present study, we show vitro-translated processed by human recombinant caspase-3, -7, and -9. Tumor necrosis factor-alpha (TNF) triggered processing of to a 43-kDa carboxyl-terminal fragment, cell-permeable caspase inhibitors prevented TNF-induced cells. was primarily at SSPD downward arrow G...
Abstract Background: Studies have shown that the combination of PD-1 inhibitors with chemotherapy exhibits promising efficacy as a first-line treatment for Asian patients recurrent or metastatic nasopharyngeal carcinoma (R/M NPC). This presentation reports results global phase 3 clinical trial ethnically diverse treated penpulimab plus vs. placebo therapy R/M NPC (NCT04974398). Methods: AK105-304 was conducted across 46 sites worldwide. Participants aged 18-75 years previously...
Nephronophthisis (NPHP) is one of the most common genetic causes CKD; however, underlying abnormalities have been established in <50% patients. We performed genome-wide analysis followed by targeted resequencing a Turkish consanguineous multiplex family and identified canonic splice site mutation ANKS6 associated with an NPHP-like phenotype. Furthermore, we four additional variants cohort 56 unrelated patients diagnosed CKD due to nephronophthisis, chronic GN, interstitial nephritis, or...
Hedgehog (Hh) is an evolutionary conserved signaling pathway that has important functions in kidney morphogenesis and adult organ maintenance. Recent work shown Hh reactivated the after injury mediator of progressive fibrosis. Pericytes fibroblasts have been proposed to be principal cells respond ligands, pharmacological attenuation considered as a possible treatment for fibrosis, but effect inhibition on tubular epithelial not reported. Using genetically modified mice which tubule-derived...
Thrombotic microangiopathy (TMA) is a disorder characterized by microvascular occlusion that can lead to thrombocytopenia, hemolytic anemia, and glomerular damage. Complement activation the central event in most cases of TMA. Primary forms TMA are caused mutations genes encoding components complement or regulators cascade. Recently, we others have described genetic form gene diacylglycerol kinase-ε (DGKE) encodes lipid kinase DGKε (Lemaire M, Fremeaux-Bacchi V, Schaefer F, Choi MR, Tang WH,...
Purpose: Severe community-acquired pneumonia (SCAP) is the leading cause of death among patients with infectious diseases worldwide. This study aimed to evaluate effectiveness metagenomic next-generation sequencing (mNGS) through detecting pathogens in bronchoalveolar lavage fluid (BALF) and identifying risk factors for recovery SCAP patients. Patients Methods: prospective recruited 158 admitted respiratory intensive care unit that were randomly divided into control groups, receiving...
The treatment of pulmonary infectious diseases with pharmaceutical aerosols is an attractive option considering the accessibility lungs for topical drug delivery. Aerosols have been targeted to asthma great success. Current therapies other diseases, including Pseudomonas aeruginosa, Pneumocystis jirovecii (formerly carinii), and mycobacterial infections, remain suboptimal due efficacy/safety profile. This may be improved by aerosol Azithromycin a broad spectrum antibiotic that acts...