A5025070645- Lung Cancer Treatments and Mutations
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Peptidase Inhibition and Analysis
- Circular RNAs in diseases
- Advanced Radiotherapy Techniques
- Lung Cancer Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Cancer Immunotherapy and Biomarkers
- Pancreatic and Hepatic Oncology Research
- Cancer-related Molecular Pathways
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer-related gene regulation
- Gastric Cancer Management and Outcomes
- Angiogenesis and VEGF in Cancer
- Cancer, Hypoxia, and Metabolism
- Ferroptosis and cancer prognosis
- Cancer Genomics and Diagnostics
- MicroRNA in disease regulation
- Nuclear Structure and Function
- Lung Cancer Research Studies
- Glutathione Transferases and Polymorphisms
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Colorectal Cancer Treatments and Studies
- Genetic factors in colorectal cancer
Qingdao University
2014-2024
Qingdao Municipal Hospital
2016-2024
Chengdu Institute of Biology
2021
Dalian Medical University
2020
Affiliated Hospital of Qingdao University
2012-2015
Yangon University of Economics
2010
Tohoku Medical and Pharmaceutical University
2000
Purpose: Pancreatic cancer is a highly aggressive malignant tumour with poor prognosis. The median survival only 6 months. This study investigated the prognostic value of nuclear export protein chromosomal region maintenance/exportin 1/Xpo1 (CRM1) expression in pancreas cancer. Methods: CRM1 was detected, by Western blot, pancreatic tissue from 69 patients and 10 normal subjects. Results: showed increased (P = 0.007). high associated serum levels CEA 0.002) CA19-9 0.005). There an...
Abstract Micro RNA s (mi s) have been identified as important post‐transcriptional regulators involved in various biological and pathological processes of cells. In the present study, we investigated roles mechanisms miR‐200b human breast cancer ( BC ). MiR‐200b expression was carried out by qRT ‐ PCR cell lines clinical samples prognostic potential further evaluated. vitro , effects on proliferation, apoptosis cycle distribution were tested CCK ‐8 kit, flow cytometric analysis respectively....
In present study, we are to clear demonstrate the genetic evidence of IDO signaling's impact on invasion and metastasis in lung cancer. Here examined IDO1 expression levels non-small cell cancer (NSCLC) patients (64) tumor/normal pairs underwent RT-PCR comprehensive histological, immunohistochemica clinical analysis. The NSCLC cells stably expressing was analyzed for migration assays regulatory mechanism vitro vivo. As results, reported that increased by more than 3.2-fold compared with...
Lipusu is the first commercialized liposomal formulation of paclitaxel and has demonstrated promising efficacy against locally advanced lung squamous cell carcinoma (LSCC) in a small-scale study. Here, we conducted multicenter, randomized, phase 3 study to compare safety cisplatin plus (LP) versus gemcitabine (GP) as first-line treatment or metastatic LSCC.Patients enrolled were aged between 18 75 years, had (clinical stage IIIB, ineligible for concurrent chemoradiation surgery) (Stage IV)...
Although immune checkpoint inhibitors (ICIs) have greatly improved cancer treatment, the accuracy of predictive biomarkers for ICI outcomes, such as PD-L1, TMB (tumor mutation burden) or MMR (mismatch repair) deficiency, not been satisfactory. ARID family members are essential maintaining basic process genomic stability and may serve novel therapy. A total 1660 patients who received therapy were included in this pan-cancer analysis. The information values each patient collected. Survival...
Hepatocellular carcinoma (HCC) is a hypervascular cancer without effective treatment. Here we report that polypeptide of NC1 domain type VIII collagen (Vastatin) an endogenous expressed in normal liver tissue but lost the most HCC patients (73.1%). Its expression level negatively associated with tumor size (P = 0.035) and metastasis 0.016) patients. To evaluate its potential use as therapeutic, constructed recombinant adeno-associated virus carrying Vastatin (rAAV-Vastatin) to treat...
MicroRNA (miR)‑101 copy loss is an early event in the development of human lung cancer, and it occurs 29% all cancer incidences. In addition, miR‑101 expression non‑small cell (NSCLC) known to be downregulated. The aim present study was explore roles mechanisms long non‑coding (lnc)‑RNA pro‑transition associated RNA (PTAR) on NSCLC proliferation, migration invasion association with miR‑101. Reverse transcription‑quantitative PCR analysis performed detect lncRNA PTAR 30 paired tissues...
Abstract Background At present, the expression of MOR1 and its function in gastric cancer remains unclear with evidence suggesting that it is to be involved tumor progression metastasis. The study was assess clinicopathologic relevance prognostic value cancer. Methods Real‐time quantitative RT‐PCR immunohistochemical staining were used detect primary cancerous surgical specimens adjacent nontumorous tissues. Results High detected compared their In addition, chi‐square test revealed high...
Purpose: Non-small cell lung cancer (NSCLC) is the leading worldwide source of cancer-related deaths. Although some drugs targeting epidermal growth factor receptor (EGFR) mutations have been developed, most advanced NSCLC still incurable and new targets for anticancer are in demand. BRCA1-associated protein-1 (BAP1) a component ubiquitin proteasome system (UPS). UPS has emerged as potential target drugs. The aim present study was to investigate expression BAP1 protein patients with NSCLC....
Background NPM, TFF3 and TACC1 are molecular markers that play important roles in cell differentiation. Herein, we investigated their prognostic impact patients with primary gastric cancer (GC) determined whether they could be used as of more aggressive carcinomas by detecting the extent expression human carcinoma samples. Methodology/Principal Findings Tumor tissue specimens from 142 GC were retrospectively retrieved immunohistochemically evaluated. Correlations between over-expression...
Rnf2 is a fundamental component of the polycomb repressive complex 1and acts as really interesting new gene finger E3 ligase, which responsible for histone 2A modification. Previous studies have shown that ring protein 2 (Rnf2) overexpressed in various types tumor and has close association with development. However, few been carried out into expression biological function gastric cancer cells. The present study measured cells normal epithelial results demonstrate upregulated In addition,...
Background: Gastric cancer is a serious health issue caused by H. pylori and claims more lives in developing undeveloped countries.Hence, the need for natural drug with several pharmacological activities no adverse effect are highly recommended.The target of this study was to verify anti-H.pyloric efficacy mangiferin (MF) on pyloriinfected AGS cells.Materials methods: cells were co-cultured incubated increased concentration MF (10, 20, 50 100 µg/mL) or amoxicillin (AMX) DMSO (control) group...
The vimentin gene is a hallmark of epithelial-to-mesenchymal transition and has been observed to be overexpressed in various types tumor cell line tissue. Previous studies have reported correlations between DNA methylation levels subsequent expression solid tumors, including breast colorectal cancer; however, the best our knowledge, such correlation not for gastric cancer (GC) using Lauren classification. Therefore, present study aimed quantify quantitative (q) methylation-specific...
PURPOSE: The aim was to evaluate the safety, feasibility and efficacy of computed tomography (CT)-guided percutaneous interstitial brachytherapy using radioactive iodine-125 (125 I) seeds for treatment lung cancer. MATERIALS AND METHODS: Included in this study were 45 male 35 female patients aged 52-85 years (mean 72-year) who diagnosed with Of 80 cases cancer, 38 pathologically confirmed as squamous cell carcinoma, 29 adenocarcinoma, 2 small 11 metastatic Percutaneous implantation...
Nucleophosmin/B23 and CRM 1 are molecular markers which play an important role in tumorigenesis tumor progression gastric cancer ( GC ). However, the association between two remains unclear. This study evaluated expression correlation of B23 . adjacent noncancerous tissues ANCT ) gastrectomy specimens from 131 patients was measured by immunohistochemistry. Positive rates were significantly higher than The high with more advanced stages distant metastasis (all p < 0.05). Only 1was...
We compared the efficacy, safety, and immunogenicity of MIL60 with reference bevacizumab as first-line treatment in patients advanced or recurrent non-squamous non-small cell lung cancer (NSCLC) this phase 3, randomized, double-blind study.Patients untreated NSCLC were randomized (1:1 ratio) to receive either combination paclitaxel/carboplatin. Patients non-progressive disease continued maintenance single-agent until progression, intolerable toxicity. The primary endpoint was 12-week...
Abstract Purpose This study aimed to assess the effects of bladder filling during cervical cancer radiotherapy on target volume and organs at risk (OARs) dose based daily computed tomography (daily‐CT) images provide bladder‐volume‐based prediction models. Methods Nineteen patients (475 daily‐CTs) comprised group, five validation set (25 daily‐CTs). Target volumes OARs were delineated daily‐CT treatment plan was recalculated accordingly. The deviation from planning (DVB), correlation between...
Lymphocyte activation gene-3 (LAG-3) is a member of the immunoglobulin superfamily. Engagement LAG-3 by its ligands to trigger downstream signaling can inhibit immune responses and regulate pathogenesis many diseases, including cancer inflammatory diseases.We used keywords search for relevant publications in PubMed information on websites. After systematic analysis, we discuss biological characteristics ligands, related signaling, roles tumors, blockages treatment cancers, as well current...
Abstract Aims In this study, we intended to analyze the clinical significance of CD4 + FoxP3 Tregs in gastric cancer patients and investigate relationship between proportion peripheral blood expression FoxM1 Ki‐67 tissues. Methods Flow cytometry was used measure level from 70 one day before gastrectomy D2 lymph node dissection. Immunohistochemistry staining detect Data on clinico‐pathological features correlation were then analyzed. Results The average patients’ surgery 10.12 ± 2.85%, which...