A5078874942- Liver Disease Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Liver Disease and Transplantation
- RNA modifications and cancer
- Hydrology and Watershed Management Studies
- Lung Cancer Treatments and Mutations
- Water resources management and optimization
- Cancer-related molecular mechanisms research
- Immunotherapy and Immune Responses
- Healthcare and Venom Research
- Ferroptosis and cancer prognosis
- Peptidase Inhibition and Analysis
- MicroRNA in disease regulation
- Glycosylation and Glycoproteins Research
- Acupuncture Treatment Research Studies
- Cancer Research and Treatments
- Traditional Chinese Medicine Studies
- Soil and Water Nutrient Dynamics
- Organ Transplantation Techniques and Outcomes
- Histone Deacetylase Inhibitors Research
- Water-Energy-Food Nexus Studies
- Risk and Portfolio Optimization
- Ubiquitin and proteasome pathways
- Lung Cancer Research Studies
- Chromatin Remodeling and Cancer
The Affiliated Yongchuan Hospital of Chongqing Medical University
2021-2023
Chongqing Medical University
2021-2023
Chengdu Fifth People's Hospital
2019-2023
Wenzhou Medical University
2022
First Affiliated Hospital of Wenzhou Medical University
2022
Qingdao University
2015-2022
Qingdao Municipal Hospital
2015-2022
Ono Pharmaceutical (United States)
2013-2017
Research & Development Institute
2017
Merck Serono (Italy)
2013
Gastric cancer (GC) is one common which occurs in the stomach leading to high mortality around world. Long non-coding RNAs (lncRNAs) were found overexpressed or silenced occurrence and progression of multiple cancers including GC.The gene expression level GC tissues cells analyzed by RT-qPCR. CCK-8, colony formation, flow cytometry transwell assays performed for function analysis HLA complex group 11 (HCG11). The mechanism study HCG11 was conducted using RIP, RNA pull down luciferase...
Although immune checkpoint inhibitors (ICIs) have greatly improved cancer treatment, the accuracy of predictive biomarkers for ICI outcomes, such as PD-L1, TMB (tumor mutation burden) or MMR (mismatch repair) deficiency, not been satisfactory. ARID family members are essential maintaining basic process genomic stability and may serve novel therapy. A total 1660 patients who received therapy were included in this pan-cancer analysis. The information values each patient collected. Survival...
Next-generation sequencing (NGS)-based circulating tumor DNA (ctDNA) assays have provided a new method of identifying tumor-driving genes in patients with advanced non-small cell lung carcinoma (NSCLC), especially those whose cancer tissues are unavailable or that acquired treatment resistance. Here, we describe total 119 EGFR-TKI-naive NSCLC and 15 EGFR-TKI-resistant to identify somatic SNVs, small indels, CNVs gene fusions 508 tumor-related genes. Somatic ctDNA mutations were detected...
Objectives We aimed to evaluate recompensation factors among patients with decompensated cirrhosis. Design A multicentre retrospective case–control study was conducted. Data were collected from and compared between groups of recompensated acute Univariable multivariable logistic regressions used select indicators associated cirrhosis different complications. decision tree 10-fold cross-validation develop the model identify recompensation. followed transparent reporting a prediction for...
ADP-ribosylation factor (Arf)-GTPase-activating protein (GAP) with coiled-coil, ankyrin repeat and PH domains 1 (ACAP1) has been reported to serve as an adaptor for clathrin coat complex playing a role in endocytic recycling cellular migration. The potential of ACAP1 lung adenocarcinoma (LUAD) not yet completely defined. We performed the comprehensive analyses, including gene expression, survival analysis, genetic alteration, function enrichment, immune characteristics. was remarkably...
This study aimed to construct a risk prediction model estimate the odds of osteoporosis (OP) in elderly patients with type 2 diabetes mellitus (T2DM) and evaluate its efficiency.This included 21,070 T2DM who were hospitalized at six tertiary hospitals Southwest China between 2012 2022. Univariate logistic regression analysis was used screen for potential influencing factors OP least absolute shrinkage. Further, selection operator (LASSO) multivariate analyses performed select variables...
Although the elderly constitute more than a third of hepatocellular carcinoma (HCC) patients, they have not been adequately represented in treatment and prognosis studies. Thus, there is enough evidence to guide such patients. The objective this study identify prognostic factors older patients with HCC construct new model for predicting their overall survival (OS). 2,721 aged ≥ 65 were extracted from public database-Surveillance, Epidemiology, End Results (SEER) randomly divided into...
Background:The evolution of adriamycin (ADR) resistance in the treatment breast cancer often leads to a poor prognosis patients.Ubiquitin-specific peptidase 37 (USP37) has been recently identified as modulator regulating stemness cells, but its underlying mechanism remains unclear.In this study, we investigated whether USP37 knockdown could hamper chemical MCF-7 and MCF-7/ADR cells elucidated potential mechanism.Methods: Immunohistochemistry, western blotting, RT-qPCR assays were performed...
Abstract Dual targeting of the programmed death ligand 1 (PD-L1) and transforming growth factor β (TGFβ) pathways, 2 key mediators tumor immune evasion, may provide synergistic antitumor activity. The novel bifunctional fusion protein M7824 (MSB0011359C) is a fully human IgG1 monoclonal antibody against PD-L1, fused via glycine-serine linker at CH3-C terminus to extracellular domain TGFβ receptor II, which functions as “trap.” Thus, designed exert independent complementary...
Background: Several recent studies have addressed the role of Na+/H+ exchanger isoform 1 (NHE1) in tumor cell growth and apoptosis, including gastric cancer. However, NHE1 expression related to 5-Fu resistance cancer has not been investigated. Methods: The was examined by qPCR SGC7901/5-FU line its parental line. pcDNA3.1-NHE1 NHE1-siRNA were transfected cells apoptosis detected via TUNEL assay. upstream activators mediated resistant Western blot immunofluorescent. Results: A significant...
Background Liver cirrhosis is a major global health and economic challenge, placing heavy burden on patients, families, society. This study aimed to investigate medical expenditure trends in patients with liver assess the drivers for such among cirrhosis. Methods Medical data concerning was collected six tertiary hospitals Chongqing, China, from 2012 2020. Trends expenses over time according subgroups were described, compositions analyzed. A multiple linear regression model constructed...
Introduction: An elderly patient with advanced small cell lung cancer who had a history of smoking and previously tuberculosis chronic kidney disease relapsed after classical treatment etoposide combined carboplatin. Methods: The was given chemotherapy again, albumin-bound paclitaxel, capsules, apatinib, other treatment. last medication apatinib. Results: After anlotinib, the has survived for 15 months good quality life. Conclusion: This is first report on precise efficacy anlotinib in...
Background and Aims: Patients with acute decompensated (AD) cirrhosis are frequently readmitted to the hospital. An accurate predictive model for identifying high-risk patients may facilitate development of effective interventions reduce readmission rates. Methods: This cohort study AD was conducted at six tertiary hospitals in China between September 2012 December 2016 (with 705 derivation cohort) January 2017 April 2020 251 temporal validation cohort). Least absolute shrinkage selection...
Background The International Normalized Ratio (INR) is significantly associated with Hepatic Encephalopathy (HE) in patients liver cirrhosis. However, the dose-response relationship between continuous INR changes and HE risk has not been clearly defined. Thus, our goal was to explore among hospitalized cirrhosis evaluate role of as a factor for these patients. Methods A total 6,266 people were extracted from Big Data Platform Medical Research Institute Chongqing University. In this study,...
Necroptosis, which is recently recognized as a form of programmed cell death, plays critical role in cancer biology, including tumorigenesis and immunology. It was not only to defend against tumor progression by suppressing adaptive immune responses but also promote metastasis after recruiting inflammatory responses. Thus the crucial necrosis has attracted increasing attention. Due heterogeneity microenvironment (TIME) lung adenocarcinoma (LUAD), prognosis response immunotherapy vary...
e22533 Background: Advanced sarcoma progressed quickly with abundant blood supply, which is known for its poor clinical response to chemotherapy. Apatinib, a novel small molecule tyrosine kinase inhibitor targeted VEGFR2, has been recommended as third-line treatment metastatic gastric cancer patients, showed improved PFS and OS in patients who had experienced failure two or more chemotherapy regimens. This study an initial experience about curative effect adverse reaction of Apatinib...
e22078 Background: Circulating tumor DNA (ctDNA) is an optional specimen used to identify potentially targetable genetic alterations in solid tumors, particularly for those that developed treatment resistance and cancer tissue sample cannot be obtained. There are still few sensitive clinically applicable ctDNA detection methods. In this study, we a broad, hybrid capture-based next generation sequencing (NGS) assay screen actionable plasma with diverse patients. Methods: 147 cases of advanced...
e15038 Background: Patients with metastatic colorectal cancer are now recommended to profile for RAS and BRAF mutations before receiving cetuximab or panitumumab. However, lots of patients both wild-type tumors determined by non-NGS testing might still not respond due the presence additional gene mutation such as PIK3CA PTEN. Therefore, it’s necessary screen in genes other than on efficacy anti-EGFR therapy. Besides, new available agents could potentially be used based targetable alterations...
Abstract Background. L-BLP25 is an investigational antigen-specific cancer immunotherapeutic agent targeting human mucin 1 (MUC1). A single low dose of cyclophosphamide (CPA) known to be immunostimulatory and may enhance the anti-tumor effects when given 3 days before treatment initiation. Here we report immune efficacy with CPA pretreatment in subcutaneous (s.c.) orthotopic models murine pancreatic cancer. These allow for reproduction clinical scenario, where 8 weekly doses are...
Meeting abstracts Tecemotide is a MUC1 antigen-specific therapeutic cancer vaccine. In phase III clinical studies, delivery of tecemotide preceded by single low dose cyclophosphamide (CPA) to inhibit regulatory T cells (Tregs) and enhance the response tumor-associated antigen. Here,