A5063077563- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Lymphoma Diagnosis and Treatment
- Circular RNAs in diseases
- Peptidase Inhibition and Analysis
- MicroRNA in disease regulation
- Lipid metabolism and disorders
- Hematopoietic Stem Cell Transplantation
- Gastric Cancer Management and Outcomes
- Galectins and Cancer Biology
- Atherosclerosis and Cardiovascular Diseases
- Pancreatic and Hepatic Oncology Research
- Esophageal Cancer Research and Treatment
- Cancer therapeutics and mechanisms
- Epigenetics and DNA Methylation
- Cancer, Lipids, and Metabolism
- bioluminescence and chemiluminescence research
- FOXO transcription factor regulation
- PI3K/AKT/mTOR signaling in cancer
- Polyamine Metabolism and Applications
- Thermal Regulation in Medicine
- Cancer Mechanisms and Therapy
- Cancer Cells and Metastasis
- Integrated Energy Systems Optimization
- Protein Tyrosine Phosphatases
China Power Engineering Consulting Group (China)
2025
Henan Provincial People's Hospital
2025
Zhengzhou University
2013-2024
Henan Cancer Hospital
2009-2024
Ningbo First Hospital
2020-2024
Ningbo University
2024
Eighth Affiliated Hospital of Sun Yat-sen University
2023
Sun Yat-sen University
2023
Lanzhou University
2023
Lanzhou University Second Hospital
2023
For the study, we determine potential biomarkers and uncover regulatory mechanisms of lncRNA MALAT1 / miR-145 SOX9 axis on abilities cell growth metastasis colorectal cancer.Previously published dataset GSE18105 from GEO database was used for microarray analysis to identify differential-expressed lncRNAs mRNAs. The miRNA which had targeted relationships with both mRNA predicted using miRCode Targetscan. association between miRNA, verified dual-luciferase reporter assay. Expression levels...
The aim of this study was to correlate matrix metalloproteinase-2 and metalloproteinase-9 expression with the clinicopathological features outcome patients early gastric cancer clinically elucidate more information on role protein overexpression regard lymph node metastasis cancer. levels were assessed by immunohistochemistry. An association observed between metalloproteinase-2, metalloproteinase-9, metalloproteinase-2/matrix factors, such as ulceration metastasis. Furthermore, both strongly...
Abstract Anthracycline-based chemotherapy resistance represents a major challenge in diffuse large B-cell lymphoma (DLBCL). MiRNA and gene expression profiles ( n = 47) were determined to uncover potential chemoresistance mechanisms therapeutic approaches. An independent correlation between high of miRNA-363-3p was observed validated larger cohort 106). MiRNA-363-3p shown reduce doxorubicin-induced apoptosis tumor shrinkage vitro vivo experiments by ectopic CRISPR/Cas9-mediated knockout...
To investigate the role and underlying mechanism of sigma-1 receptor (SigmaR1)/high mobility group A1 (HMGA1) in pathogenesis diminished ovarian reserve (DOR). In vitro cell experimental study. The Reproductive Medical Center, People's Hospital Zhengzhou University. Serum, follicular fluid (FF), granulosa cells (GCs) KGN cells. Samples were collected from DOR patients. Endoplasmic reticulum (ER) stress was induced GCs using thapsigargin (TG). mRNA protein levels determined reverse...
Considering the power demand in high-altitude special environmental areas and peak-regulation issues system caused by uncertainties associated with wind photovoltaic as well load, a gas–hydro coordinated peak-shaving method that considers source-load uncertainty is proposed. Firstly, based on regulation-related characteristics of hydropower gas power, gas−hydro operation mode Secondly, operational risk quantified Conditional Value-at-Risk theory. Then, cost deep peak shaving connection...
Abstract This study sought to investigate the biological effects of specific MIF inhibitor, ISO-1, on proliferation, migration and invasion PANC-1 human pancreatic cells in vitro , tumour growth a xenograft model vivo . The effect ISO-1 cell proliferation was examined using CCK-8 assay. collective recolonization evaluated cell-wound closure individual 3-dimensional environment response chemo-attractant investigated through use Transwell migration/invasion assays. Quantitative real time PCR...
This study investigates the inhibitory mechanism of anlotinib on human Mantle Cell Lymphoma (MCL) cells through in vitro and vivo experiments.
Abstract Multiple studies have unveiled that long non‐coding RNAs (lncRNAs) play a pivotal role in tumour progression and metastasis. However, the biological of lncRNA ZEB1‐AS1 oesophageal squamous cell carcinoma (ESCC) remains under investigation, thus, current study was to investigate functions proliferation invasion ESCC. Here, we discovered ZEB1 were markedly up‐regulated ESCC tissues cells relative their corresponding normal control. overexpressions both related TNM staging lymph node...
Objectives: The mechanism and immunoregulatory role of natural killer (NK) cells in human graft-versus-host-disease (GVHD) remains unclear. This study quantitatively analyzed the cytotoxicity donor NK towards alloreactive T cells, investigated their relationship with acute GVHD (aGVHD). Methods: We evaluated dose, subgroup, receptor expression allografts from 98 patients receiving allogeneic hematopoietic stem cell transplantation (allo-HSCT). A CD107a degranulating assay was used as a...
An increasing number of studies have demonstrated that long non‑coding (lnc)RNAs are associated with tumor invasion, metastasis and the prognosis patients a variety different tumors. However, roles lncRNA prostate androgen regulated transcript 1 (PART1) in esophageal squamous cell carcinoma (ESCC) remain unknown. In present study, reverse transcription‑quantitative PCR was performed to investigate levels PART1, SRY‑box transcription factor 6 (SOX6) miR‑18a‑5p ESCC tissues cells. The...
We compared the efficacy, safety, and immunogenicity of MIL60 with reference bevacizumab as first-line treatment in patients advanced or recurrent non-squamous non-small cell lung cancer (NSCLC) this phase 3, randomized, double-blind study.Patients untreated NSCLC were randomized (1:1 ratio) to receive either combination paclitaxel/carboplatin. Patients non-progressive disease continued maintenance single-agent until progression, intolerable toxicity. The primary endpoint was 12-week...
Abstract Background Mitofusin 2 (MFN2) plays an important role in many tumors, but how its renal clear cell carcinoma needs further research. Methods In this study, we analyzed the expression of MFN2 tissues and normal kidney through Cancer Genome Atlas (TCGA) database our clinical samples.Enrichment analysis was performed to determine MFN2-related pathways biological functions. The correlation with immune cells analyzed.The methylation sites were by UALCAN TCGA databases. Univariate /...
Abstract: Despite a series of attempts during the last decades, prognosis esophageal squamous cell carcinoma (ESCC) remains poor. Different responses individual tumors encouraged us to look for valuable prognostic markers. As key regulator controlling anabolic ketogenic pathway, 3-hydroxy-3-methylglutaryl-CoA synthase 2 ( HMGCS2 ) has been reported play crucial role in colorectal cancer and prostate cancer. However, its importance ESCC not verified. Therefore, large cohort retrospective...
The present study aimed to investigate microRNA-376a (miR-376a) expression in lymphoma, and the effect of miR-376a on cell proliferation apoptosis at cytological molecular levels. lymphoma issue cells was detected by reverse transcription quantitative polymerase chain reaction (RT-qPCR), forkhead box protein P2 (FOXP2) RT-qPCR western blot analysis, were studied an MTT assay flow cytometry, respectively. Additionally, levels cyclin D2, A, B, apoptosis-associated proteins B-cell 2 (Bcl-2)...
Abstract Objective: Extranodal involvement represents a peculiar presentation of diffuse large B-cell lymphoma (DLBCL). Previous studies have suggested that older patients are more prone to extranodal involvement. This study retrospectively addressed the distribution, prognostic value and treatment options in young with DLBCL. Methods: A total 329 were enrolled according inclusion requirements. The effects gender, involvement, age-adjusted international index (aaIPI), rituximab infusion...
Abstract Background Early progression after the first-line R-CHOP treatment leads to a very dismal outcome and necessitates alternative for patients with diffuse large B-cell lymphoma (DLBCL). This study aimed develop genetic predictive model early evaluate its potential in advancing treatment. Methods Thirty-two hotspot driver genes were examined 145 DLBCL 5 cell lines using next-generation sequencing. The association of clinical features, cell-of-origin, double expression, positive p53...
The purpose of this retrospective study was to evaluate the safety and efficacy docetaxel, oxaliplatin plus fluorouracil (DOF) regimen in comparison with epirubicin, cisplatin (ECF) treating AGC. A total 88 AGC patients were treated DOF (N = 45) ECF 43) respectively. end points response rate, survival, toxicity. overall rates for 42·2% 37·3%, respective tumour control 80% 60·6%, While median progression-free survival (PFS) approached 6·7 5·0 months ECF, (OS) 11·4 9·8 Although both groups...
It is important to identify some tumor-related factors for early detection, treatment, and evaluation of prognosis in colorectal cancer (CRC). In our study, we investigated the clinical prognostic role activating transcription factor 7 (ATF7) CRC.Expression ATF7 was detected with immunohistochemistry 72 cases complete follow-up data post-operation tissue specimens. Correlation between other clinicopathological calculated Chi-square test impact on survival were analyzed Log-rank Cox...
Objective: To investigate the expression levels of programmed death protein 1 (PD-1)、T cell immunoglobulin domain and mucin 3(TIM-3)、lymphocyte activating gene 3 (LAG-3) B T lymphocyte attenuator (BTLA) in Diffuse large B-cell lymphoma, not otherwise specified (DLBCL, NOS) their effects on prognosis. Methods: The paraffin specimens 30 patients with DLBCL, NOS newly diagnosed People's Hospital Zhengzhou University were stained immunohistochemistry. single positive co-expression above...
Aim: Rituximab in combination with cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) treatment failure is a rigorous problem patients diffuse large B-cell lymphoma (DLBCL), which usually predicts poor survival. The study explored the association of microRNAs R-CHOP resistance order to find reliable predictive factors novel therapeutic targets. Methods: Forty-five newly diagnosed cases DLBCL were administered regimen. Thirty-three them divided into sensitive group 12...
// Hai-ying Wang 1 , Zhi-hua Yao Hong Tang Yan Zhao Shui-ling Jin 2 Wen-ping Zhou Shu-na Shu-jun Yang Yan-yan Liu Su-xia Luo Department of Medical Oncology Henan Cancer Hospital, Zhengzhou University Affiliated Zhengzhou, Henan, China Internal Medicine, The Second Hospital University, Correspondence to: Luo, email: 470242877@qq.com Wang, luosxrm@163.com Keywords: advanced esophageal squamous cell carcinoma, Paclitaxel, S-1, cisplatin, palliative chemotherap Received: July 18,...
Background Inflammation appears to have a critical role in carcinogenesis tumor growth according emerging research. The platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte (NLR), and plasma C-reactive protein (CRP) are considered reflect the systemic inflammatory response clinical prognosis. prognostic value of indices myelodysplastic syndrome (MDS) patients remains unclear. Methods A total 213 MDS were enrolled for study. Univariate multivariate analyses performed determine...
Esophageal squamous cell carcinoma (ESCC) is one of the most frequently diagnosed cancers in China, but etiology and mode carcinogenesis this disease remain poorly understood. Phosphatase tensin homolog deleted on chromosome 10 (PTEN), as a negative regulator Akt/mTOR pathway, mutates or inactive many cancers. Although mTOR has been thought promising cancer therapeutic target, sensitivity tumor cells to rapamycin was still be revaluated. In study, we measured effects proliferation...