A5055869828- Medical Imaging Techniques and Applications
- Esophageal Cancer Research and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Diagnosis and Treatment
- Immune cells in cancer
- Chemokine receptors and signaling
- Gastric Cancer Management and Outcomes
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Advanced Radiotherapy Techniques
- Radiopharmaceutical Chemistry and Applications
- Lung Cancer Treatments and Mutations
- Pancreatic and Hepatic Oncology Research
- Circular RNAs in diseases
- Bladder and Urothelial Cancer Treatments
- Cancer Immunotherapy and Biomarkers
- Esophageal and GI Pathology
- Liver Disease Diagnosis and Treatment
- RNA modifications and cancer
- Cancer, Lipids, and Metabolism
- Immunotherapy and Immune Responses
- Viral-associated cancers and disorders
- Renal cell carcinoma treatment
Lanzhou University
2020-2024
Lanzhou University Second Hospital
2020-2024
Shandong Tumor Hospital
2013-2024
Shandong First Medical University
2013-2024
Guangzhou University
2024
Astellas Pharma (South Korea)
2024
First Affiliated Hospital of Kunming Medical University
2023
Kunming Medical University
2023
Academy of Medical Sciences
2022
Shandong University
2015-2020
Colorectal cancer (CRC, also known as colon cancer, rectal or bowel cancer) is the second leading cause of mortality in Western world. MicroRNAs (miRNAs) are a class small (18-25 nucleotides long) noncoding RNAs with important posttranscriptional regulatory functions. miRNAs play roles various physiological and pathological processes including carcinogenesis solid cancers CRC. In order to investigate that played CRC, expression human (in 20 normal adjacent tissue samples samples) was...
Tumour-associated macrophages (TAMs) are associated with both the progression and poor prognosis of a variety solid tumours. This study aimed to investigate clarify tumour-promoting role CXCL8 secreted by TAMs in urothelial carcinoma microenvironment bladder. Immunohistochemistry (n = 55) was used detect Chemokine (C-X-C motif) ligand 8 (CXCL8), CD163 (a TAM marker), Matrixmetalloproteinase-9 (MMP-9), vascular endothelial growth factor (VEGF), E-cadherin cancerous adjacent tissues bladder...
Abstract Purpose To construct machine learning models for predicting progression free survival (PFS) and overall (OS) with esophageal squamous cell carcinoma (ESCC) patients. Methods 204 ESCC patients were randomly divided into training cohort (n = 143) test 61) according to the ratio of 7:3. Two radiomics constructed by features, which selected LASSO Cox model predict PFS OS, respectively. Clinical features univariate multivariate proportional hazards ( p < 0.05). Combined clinical was...
The primary aim of this study was to use serial <sup>18</sup>F-3′-deoxy-3′-fluorothymidine (FLT) PET/CT measure tumor cell proliferation during radiotherapy squamous carcinoma (SCC) the esophagus. <b>Methods:</b> Twenty-one patients with inoperable locally advanced SCC esophagus underwent <sup>18</sup>F-FLT radiotherapy. Each patient received a pretreatment scan, followed by 1–3 scans after delivery 2, 6, 10, 20, 30, 40, 50, or 60 Gy tumor. <b>Results:</b> Among 19 who completed without...
To study the effectiveness of natural killer cell-derived exosome (NK-Exos)-entrapped paclitaxel (PTX-NK-Exos) in enhancing its anti-tumor effect.The NK-Exos were isolated through ultra-high-speed centrifugation, and PTX-NK-Exos system was constructed via electroporation. The morphology, particle size, Zeta potential entrapment rate evaluated using transmission electron microscope (TEM), dynamic light scattering (DLS), Western blotting high-performance liquid chromatography (HPLC),...
Cancer stem cells (CSCs) play an important role in tumor invasion and metastasis. CD44 is the most commonly used marker of CSCs, with potential to act as a determinant against migration CSCs key factor epithelial-mesenchymal transition (EMT)-like changes that occur colorectal cancer (CRC). Runt-related transcription factor-2 (RUNX2) mesenchymal for involved cell biology tumorigenesis. However, whether RUNX2 CSC inducing EMT-like CRC remains uncertain, warranting further investigation.We...
To explore the relationships between primary tumor 18F-FDG uptake measured as SUVmax and local extension, nodal or distant organ metastasis in patients with NSCLC on pretreatment PET-CT.93 who underwent PET-CT scans before treatment were included study. Primary was calculated; clinical stages, presence of metastases recorded. The ≥ 2.5 divided into low high groups by using median SUVmax. group consisted 45 SUVmax<10.5, 46 10.5. Their data compared statistically.91 cases SUVmax≥2.5 for...
We used pathological examination as golden standard to determine whether 3-deoxy-3-(18)F-fluorothymidine positron emission tomography/computed tomography (FLT PET/CT) can detect regional lymph node metastasis in untreated thoracic esophageal squamous cell carcinoma and additionally performed (18)F-fluorodeoxyglucose (FDG) PET/CT for direct comparison with that of FLT. Twenty-two patients underwent dual-tracer examinations before surgery. The results reviewing CT images side-by-side FDG PET...
To validate a gradient-based segmentation method for gross tumor volume(GTV) delineation on 8F-fluorothymidine (FLT)positron emission tomography (PET)/ computer (CT) in esophageal squamous cell cancer through pathologic specimen, comparison with standardized uptake values (SUV) threshold-based methods and CT. The corresponding impact of this GTV treatment planning was evaluated. Ten patients were enrolled. Before radical surgery, all underwent FLT-PET/CT. GTVs delineated by using four...
Abstract Background Mitofusin 2 (MFN2) plays an important role in many tumors, but how its renal clear cell carcinoma needs further research. Methods In this study, we analyzed the expression of MFN2 tissues and normal kidney through Cancer Genome Atlas (TCGA) database our clinical samples.Enrichment analysis was performed to determine MFN2-related pathways biological functions. The correlation with immune cells analyzed.The methylation sites were by UALCAN TCGA databases. Univariate /...
Fatty acid metabolism (FAM) is an important factor in tumorigenesis and development. However, whether fatty (FAM)-related genes are associated with prostate cancer (PCa) prognosis not known. Therefore, we established a novel prognostic model based on FAM-related to predict biochemical recurrence PCa patients. First, sequencing data were acquired from TCGA as the training cohort GSE21032 validation cohort. Second, containing 10 was constructed using univariate Cox LASSO. Principal component...
The aim of this study was to assess the efficacy and safety concurrent apatinib docetaxel therapy vs monotherapy as third- or subsequent-line treatment for advanced gastric adenocarcinoma (GAC).Patients, who had received with without third more line GAC, were retrospectively reviewed. Propensity score matching (PSM) analysis performed minimize potential confounding bias. Kaplan-Meier curve log-rank test used analyze survival. Prognostic factors estimated by Cox regression. Adverse events...
Abstract Age is one of the most important risk factors occurrence for tumor patients. The majority patients with urogenital cancers are elderly, whose clinical characteristics greatly affected by age and ageing. Our study aimed to explore age-related genes, cells, biological changes in three common via integrative bioinformatics analysis. First, mRNA (count format) data bladder cancer, prostate cancer renal cell carcinoma were downloaded from Cancer Genome Atlas (TCGA). Through comparison...
This study aimed to compare the efficacy and safety of induction chemotherapy followed by concurrent chemoradiotherapy (I-CCRT), consolidation (I-CCRT-C), (CCRT-C) for locally advanced esophageal squamous cell carcinoma (ESSC).Patients with ESCC who underwent definitive cisplatin plus fluorouracil or docetaxel from February 2012 December 2018 were retrospectively reviewed. Kaplan-Meier curve was used estimate survival. Efficacy assessed using RECIST, version 1.0. Prognosis factors identified...