A5101510703- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Glioma Diagnosis and Treatment
- RNA modifications and cancer
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Immune cells in cancer
- Ubiquitin and proteasome pathways
- RNA Research and Splicing
- Cancer Immunotherapy and Biomarkers
- Bone Metabolism and Diseases
- Hydrogels: synthesis, properties, applications
- Bone health and osteoporosis research
- interferon and immune responses
- Intracranial Aneurysms: Treatment and Complications
- Bone health and treatments
- Epigenetics and DNA Methylation
- Spine and Intervertebral Disc Pathology
- Extracellular vesicles in disease
- Shoulder Injury and Treatment
- Psoriasis: Treatment and Pathogenesis
- Tendon Structure and Treatment
- Fatty Acid Research and Health
- Electronic Packaging and Soldering Technologies
- Polymer Nanocomposite Synthesis and Irradiation
Henan University
2020-2025
Zhengzhou University
2007-2025
Henan Provincial People's Hospital
2016-2025
Chengdu Institute of Biology
2024
Chinese Academy of Sciences
2024
Zhengzhou People's Hospital
2019-2021
University of Amsterdam
1991
Osteoarthritis is an inflammatory disorder associated with oxidative stress and apoptosis leading to cartilage destruction impairment of formation. In the present study, we studied protective effect lutein against monosodium iodoacetate (MIA)-induced osteoarthritis in primary chondrocyte cells.
Biomimicry, biomineralization, and bioregeneration technologies will pave the way for regenerative medicine toward better human health. Functional fibrous scaffold with extracellular matrix–like natural structure three-dimensional (3D) network is crucial to meet complex requirements of cell new bone tissue growth. In this study, we fabricated 3D hydroxyapatite (3D FHAS) biomimicry, functionalities regeneration repair injured tissues by integrated electrospinning, phase transformation,...
The use of pulsed electromagnetic field (PEMF) has demonstrated effectiveness in the management femoral head osteonecrosis as well nonunion fractures; however, effects PEMF on preventing glucocorticoid-induced osteoporosis (GIOP) have not been extensively studied. aim this investigation was to explore stimulation averting GIOP rats and uncover potential fundamental mechanisms involved. A total seventy-two adult male Wistar composed experimental group were subsequently assigned three groups...
The underlying cause of psoriasis, a chronic inflammatory skin condition driven by an immune response, remains topic active investigation and is not yet fully elucidated. Recent studies have revealed that ergothioneine, small molecule sulfur-containing histidine derivative can be ingested from the daily diet accumulated in body, exhibits antioxidant capacity comparable to glutathione. Nevertheless, there paucity empirical data concerning precise impact ergothioneine context anti-inflammatory...
Abstract Background Cysteine cathepsin C encoded by the CTSC gene is an important member of cysteine family that plays a key role regulation many types tumors. However, whether involved in pathological process glioma has not yet been reported. We comprehensively analyzed data from multiple databases and for first time revealed specific mechanism action glioma, identifying it as novel efficient biomarker diagnosis treatment this brain tumor. Methods The expression its relationship with...
Osteosarcoma (OS) is the most common bone malignant tumor in children, youth, and adolescents. Circular RNA hsa_circ_0005909 (circ_0005909) involved progression of OS. Nevertheless, there are few reports on role mechanism circ_0005909 OS.Quantitative real-time polymerase chain reaction (qRT-PCR) was executed to examine expression circ_0005909, miR-936, High Mobility Group Box 1 (HMGB1) mRNA OS tissues cells. Cell viability, colony formation, migration, invasion were evaluated by Counting...
Impressive responses have been observed in patients with cancer treated checkpoint inhibitory anti-programmed cell death-1 (PD-1) or anti-cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) antibodies through disinhibiting the immune system. However, tumors possess complex immunosuppressive tumor microenvironment to present therapeutic obstacles and response rates inhibition remain low. One significant barrier efficacy of anti-PD1 treatment is recruitment myeloid-derived suppressor cells...
Studies have indicated that collagen α‑1 (IV) chain (COL4A1) has an indispensable regulatory role in the complex pathological mechanisms of numerous types malignant tumor. However, its development glioma remained elusive. Therefore, present study sought to determine association between expression levels COL4A1 and clinical characteristics gliomas by analyzing large samples. First, analysis thousands tissue samples collected from Gene profiling interactive analysis, Expression Omnibus...
Purpose GNG12 influences a variety of tumors; however, its relationship with glioma remains unclear. The aim this study was to comprehensively investigate the between and clinical characteristics prognosis patients reveal mechanisms causing malignant process GNG12. Materials Methods We obtained information on samples from multiple databases. expression level validated using RT-qPCR IHC. KM curves were used assess correlation OS patients. An ROC curve drawn predictive performance Univariate...
Abstract Background The WD40 repeat (WDR) domain provides scaffolds for numerous protein–protein interactions in multiple biological processes. WDR 76 ( WDR76 ) has complex functionality owing to its diversified interactions; however, mechanism LGG not yet been reported. Methods Transcriptomic data from public databases were multifariously analyzed explore the role of pathology and tumor immunity. Laboratory experiments conducted confirm these results. Results results first confirmed that...
Rotator cuff injuries often necessitate surgical intervention, but the outcomes are unsatisfactory. The underlying reasons can be attributed to multiple factors, with intricate inflammatory activities and insufficient presence of stem cells being particularly significant. In this study, an innovative inflammation-responsive core-shell micro-hydrogel is designed for independent release SDF-1 IL-4 within a single delivery system promote tendon-to-bone healing by recruiting MSCs modulating M2...
Long non-coding RNAs (lncRNAs) are emerging as important regulators of the processes involved in cancer development and progression. The molecular mechanism by which lncRNAs regulate progression osteosarcoma has not been clearly elucidated. role NR_136400, is an uncharacterized lncRNA, previously reported (OS). In present study, we demonstrated that NR_136400 was downregulated OS cells its downregulation promoted cell proliferation, apoptosis, invasion. facilitated EMT inhibiting expression...
ETS transcription factor ELK3 (ELK3), a novel oncogene, affects pathological processes and progression of many cancers in human tissues. However, it remains unclear whether ELK3, as key gene, the process gliomas prognosis patients with gliomas. This study aimed to comprehensively systematically reveal correlation between malignant by analyzing clinical sample information stored multiple databases. We revealed putative mechanism involvement identified new efficient biomarker for glioma...
Fatty acid metabolism (FAM) is an important factor in tumorigenesis and development. However, whether fatty (FAM)-related genes are associated with prostate cancer (PCa) prognosis not known. Therefore, we established a novel prognostic model based on FAM-related to predict biochemical recurrence PCa patients. First, sequencing data were acquired from TCGA as the training cohort GSE21032 validation cohort. Second, containing 10 was constructed using univariate Cox LASSO. Principal component...
HOXA4 is a novel oncogene that has been observed in many kinds of tumors, but its role during glioma carcinogenesis and clinical significance diagnosing prognosis human remains unknown. In the present study, Chinese Glioma Atlas (CGGA)-RNA sequencing database, CGGA microarray, The Cancer Genome (TCGA)-RNA seq data from 1674 patients were obtained online databases analyzed using quantitative reverse transcription-polymerase chain reaction (RT-qPCR) to detect changes expression level...
The undetectable onset of glioma and the difficulty surgery lead to a poor prognosis. Appropriate biomarkers for diagnosis treatment need be identified. Interleukin‑1 receptor‑associated kinase 4 (IRAK4) is involved in initiation progression cancer. However, up until now, no report has revealed relationship between IRAK4 glioma. present study aimed examine expression glioma, determine if there was clinical outcomes or survival Thousands tissue samples corresponding information were obtained...
Background: Recent studies have demonstrated that upregulation of heat shock transcription factor 2 binding protein (HSF2BP) may promote genomic instability, thereby leading to the development tumors and also providing a potential target for biological antitumor therapy. However, role HSF2BP has so far remained unclear in lung adenocarcinoma (LUAD). Methods: To explore function LUAD, we collected transcriptome data 551 samples from The Cancer Genome Atlas (TCGA) database methylation 461...
Abstract: As a masterpiece of existentialist literature, The Outsider occupies an important position in the literary genre and offers profound insights into nature human existence. Based on literature review qualitative analysis, this article explores qualities loneliness, alienation free choice shown Outsider. affirms work's inheritance tradition, by emphasizing meaninglessness individual existence, weight choice, portrayal dystopian world. It also delves deeply evolution innovation...