A5101450770- Spinal Fractures and Fixation Techniques
- Spine and Intervertebral Disc Pathology
- Medical Imaging and Analysis
- Cervical and Thoracic Myelopathy
- Nanoplatforms for cancer theranostics
- Catalysts for Methane Reforming
- Orthopedic Infections and Treatments
- Infectious Diseases and Tuberculosis
- Catalytic Processes in Materials Science
- Autophagy in Disease and Therapy
- Titanium Alloys Microstructure and Properties
- Ginseng Biological Effects and Applications
- Traditional Chinese Medicine Analysis
- Bone Tissue Engineering Materials
- Nanoparticle-Based Drug Delivery
- Neonatal and Maternal Infections
- Cardiac Imaging and Diagnostics
- Shoulder and Clavicle Injuries
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Management of metastatic bone disease
- Additive Manufacturing Materials and Processes
- Surgical Sutures and Adhesives
- Composting and Vermicomposting Techniques
- Medical Imaging Techniques and Applications
- Neurogenesis and neuroplasticity mechanisms
First Affiliated Hospital of Xi'an Jiaotong University
2021-2024
First Hospital of Xi'an
2022-2024
Taiyuan University of Technology
2024
Tobacco Research Institute
2024
Chinese Academy of Agricultural Sciences
2024
Shenzhen University
2024
Xi'an Jiaotong University
2023
Guangzhou University of Chinese Medicine
2022-2023
Henan Provincial People's Hospital
2018-2021
Zhengzhou University
2021
Bone implants for different body parts require varying mechanical properties, dimensions, and biodegradability rates. Currently, it is still challenging to produce artificial bones with perfect compatibility human bones. In this study, a silk-fabric reinforced silk material (SFS) composed of pure exceptional biocompatibility, osteogenesis, reported, demonstrates its outstanding performance as bone implant material. The SFS fabricated using simple hot-pressing technique, degummed fabric the...
The design of porous structure that mimic trabecular bone is an effective method for optimizing the elastic modulus and osseointegration properties titanium alloy implants. However, there no consensus on which best. In this study, we fabricated 24 different types Ti6Al4V scaffolds with varying porosity average pore size using Voronoi algorithm selective laser melting technology. biomechanics were studied by mechanical tests, computational fluid dynamics, cell animal experiments. Our results...
BACKGROUND:The aim of this study was to evaluate the clinical and radiological outcomes use a new 3D-printed anatomy-adaptive titanium mesh cage (AA-TMC) for single-level anterior cervical corpectomy fusion (ACCF) in patients with spondylotic myelopathy (CSM) ossification posterior longitudinal ligament (OPLL). MATERIAL AND METHODS:We retrospectively reviewed records 15 consecutive who underwent ACCF surgeries AA-TMC implantation. The Japanese Orthopedic Association (JOA) scoring system,...
Abstract Purpose To demonstrate a novel contrast mechanism for imaging the vessel wall and calcification using susceptibility‐weighted (SWI). Materials Methods Eighteen subjects were imaged with multidetector computed tomography (MDCT) high‐resolution SWI at 3T. The parameters optimized to allow best visualization of femoral artery lumen arterial in magnitude phase images, respectively. SWI‐filtered data used evaluate diamagnetic susceptibility putative calcification. Imaging was performed...
Nanodynamic therapy (NDT) based on reactive oxygen species (ROS) production has been envisioned as an effective cancer treatment. However, the efficacy is limited by hypoxia, insufficient hydrogen peroxide conversion, and high glutathione (GSH) levels in tumor microenvironment (TME). To solve these issues, we proposed designed a biocompatible, resistant Cu-modified Ti
Although Tongguan capsule (TGC) is used in the treatment of coronary atherosclerotic disease, exact mechanism remains unclear.Network pharmacology and experimental validation were applied to examine TGC for treating myocardial ischemia-reperfusion injury (MIRI).The components candidate targets searched based on various databases such as TCMSP, TCMID, BATMAN-TCM. The binding ability was determined by molecular docking. (I/R) model constructed ligating left anterior descending (LAD) artery....
Introduction: Ti6Al4V titanium alloy is widely used in producing orthopedic and maxillofacial implants, but drawbacks include high elastic modulus, poor osseointegration performance, toxic elements. A new medical material with better comprehensive performance urgently needed the clinic. Methods: Ti10Mo6Zr4Sn3Nb (referred to as Ti-B12) a unique ß developed by us. The mechanical properties of Ti-B12 depict that it has advantages, such strength, low fatigue resistance. In our study,...
Streptococcus suis 2 is an important swine pathogen and emergent zoonotic pathogen. Excessive inflammation caused by S. responsible for the high levels of early mortality observed in septic shock-like syndrome cases. However, mechanisms through which (SS2) causes excessive remain unclear. Thus, this study aimed to identify novel pro-inflammatory mediators that play roles development therapies against SS2 infection. In study, protein HP0459, was encoded SSUSC84_0459 gene, discovered. The...
Studies have indicated that collagen α‑1 (IV) chain (COL4A1) has an indispensable regulatory role in the complex pathological mechanisms of numerous types malignant tumor. However, its development glioma remained elusive. Therefore, present study sought to determine association between expression levels COL4A1 and clinical characteristics gliomas by analyzing large samples. First, analysis thousands tissue samples collected from Gene profiling interactive analysis, Expression Omnibus...
MicroRNAs (miRNAs) function as gene expression switches, and participate in diverse pathophysiological processes of spinal cord injury (SCI). Olfactory ensheathing cells (OECs) can alleviate pathological facilitate functional recovery after SCI. However, the mechanisms by which OECs restore are not well understood. This study aims to determine whether silencing miR-199a-5p would enhance beneficial effects OECs. In this study, we measured levels rat cords with without injury, OEC transplants....
To compare the biomechanical properties of a new memory compression alloy plate and traditional titanium after anterior cervical discectomy fusion (ACDF).A finite element model C3-7 segments was developed validated. The C5-6 disc removed, an intervertebral cage made peek material implanted. Then, composed Ti-Ni were integrated at segment. All models subjected to load 73.6 N simulate head weight 1 Nm flexion-extension, lateral bending, axial rotation. range segmental motion (ROM) stress on...
Abstract The aim of the study was to evaluate biomechanical properties a novel nonfused artificial vertebral body in treating lumbar diseases and compare with those fusion body. An intact finite element model L1–L5 spine constructed validated. Then, models group nonfusion were by replacing L3 adjacent intervertebral discs prostheses. For all models, an axial preload 500 N another 10 m imposed on superior surface L1. range motion stress peaks discs, endplates, facet joints compared among...
OBJECTIVE. The objective of our study was to prospectively evaluate the feasibility, safety, and effectiveness 1-T open MRI-guided percutaneous cryoablation hepatic dome hepatocellular carcinomas (HCCs). SUBJECTS AND METHODS. Thirty-seven patients with 37 HCCs underwent cryoablations. MR fluoroscopy a freehand technique applied in procedure. All lesions ranged size from 8 38 mm. Patients were followed for at least 12 months after or until death. Survival period, local tumor control,...
This was an in vivo study to develop a novel movable lumbar artificial vertebral complex (MLVC) goat model. The purpose of this evaluate clinical and biomechanical characteristics MLVC provide preclinical data for trial the future.According preoperative X-ray CT scan vertebrae, 3D printing designed implanted goats. animals were randomly divided into three groups: intact, fusion, nonfusion. In intact group, only vertebrae intervertebral discs exposed during surgery. Both fusion nonfusion...
There are various internal fixation methods in treating lumbosacral spinal tuberculosis. The study compared the stability and stress distribution surrounding tissues/implants, such as discs, endplates screw-rod system, etc. when applying three different lumbar to treat A finite element model was constructed validated. restored using methods: a titanium cage with lateral double (group 1), autologous bone posterior 2), 3). For comparison, group 4 represented intact L3-S1 spine. Finally, load...
The prevalence of 23 putative virulence factors among fluoroquinolone-susceptible and -resistant Haemophilus parasuis isolates was analyzed. Putative hemolysin precursor, fimbrial assembly chaperone, type I site-specific restriction modification system R subunit genes were more prevalent fluoroquinolone-resistant H. than isolates. Fluoroquinolone resistance may be associated with an increase in the presence some factors.
Mobile artificial lumbar complex (MALC) which suitable for reconstruction after subtotal resection in goats was developed,and to test stability of the and postoperative segmental motor function.
Accumulated evidence indicates that the activating transcription factor 4 (atf4) is a developmentally relevant gene. Here, we report on characterization of atf4 in Xenopus embryos, which differentially expressed central nervous system, eyes, blood, and pronephros, as well developing endodermal organs such stomach, duodenum, liver, pancreas. Ectopic expression animal hemisphere embryos had no obvious effects induction neural progenitors, but suppressed neurogenesis eye formation without...
To investigate the clinical effect of anterior cervical discectomy and fusion (ACDF) in treatment spondylosis vertebral artery type(CSA).