Huiqi Chen

ORCID: 0000-0002-4608-4495
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About
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Research Areas
  • Climate Change and Health Impacts
  • Air Quality and Health Impacts
  • Birth, Development, and Health
  • Gestational Diabetes Research and Management
  • Global Health Care Issues
  • Pregnancy and preeclampsia studies
  • Extracellular vesicles in disease
  • Ginseng Biological Effects and Applications
  • Traditional Chinese Medicine Analysis
  • Autophagy in Disease and Therapy
  • CRISPR and Genetic Engineering
  • Inflammasome and immune disorders
  • Pharmacological Effects of Natural Compounds
  • Health disparities and outcomes
  • Genetics, Aging, and Longevity in Model Organisms
  • Antibiotics Pharmacokinetics and Efficacy
  • Nanoplatforms for cancer theranostics
  • Lipoproteins and Cardiovascular Health
  • Retinoids in leukemia and cellular processes
  • Biomarkers in Disease Mechanisms
  • Ferroptosis and cancer prognosis
  • Cardiac Ischemia and Reperfusion
  • Pneumonia and Respiratory Infections
  • Circular RNAs in diseases
  • Anesthesia and Pain Management

Fudan University
2025

Sun Yat-sen University
2021-2024

Guangzhou University of Chinese Medicine
2020-2024

ShanghaiTech University
2023

China Meteorological Administration
2022

Vanke (China)
2022

Tsinghua University
2022

Shanghai Meteorological Bureau
2022

Jinan University
2021

Zhejiang University
2020-2021

BackgroundIn China, most previous projections of heat-related mortality have been based on modeling studies using global climate models (GCMs), which can help to elucidate the risks extreme heat events in a changing climate. However, spatiotemporal changes health effects change considering specific regional characteristics remain poorly understood. We aimed use credible and population estimate future heatwave-attributable deaths under different emission scenarios explore drivers underlying...

10.1016/j.lanwpc.2022.100582 article EN cc-by The Lancet Regional Health - Western Pacific 2022-09-06

China, with its growing population and economic development, faces increasing risks to health from climate change, but also opportunities address these protect for generations come. Without a timely adequate response, change will impact lives livelihoods at an accelerated rate. In 2020, the Lancet Countdown Regional Centre in Asia, led by Tsinghua University, built on work of global began assessment profile China aim triggering rapid health-responsive actions. This 2021 report is first...

10.1016/s2468-2667(21)00209-7 article EN cc-by The Lancet Public Health 2021-11-07

Frequent heatwaves under global warming can increase the risk of preterm birth (PTB), which in turn will affect physical health and human potential over life course. However, what remains unknown is extent to anthropogenic climate change has contributed such burdens. We combine impact economic assessment methods comprehensively evaluate entire heatwave-related PTB burden dimensions health, capital costs. Here, we show that during 2010-2020, an average 13,262 (95%CI 6,962-18,802) PTBs...

10.1038/s41467-022-35008-8 article EN cc-by Nature Communications 2022-12-13

Defect engineering critically influences metal oxide catalysis, yet controlling coordinatively unsaturated sites remains challenging due to their inherent instability under reaction conditions. Here, we demonstrate that high-flux argon ion (Ar+) irradiation above recrystallization temperatures generated well-defined Zn (CUZ) on ZnO(101̅0) surfaces exhibited enhanced stability and activity for CO hydrogenation. Combining low-temperature scanning probe microscopy, ambient pressure X-ray...

10.1021/jacs.4c13234 article EN Journal of the American Chemical Society 2025-02-04

Berberine (Ber) can increase the survival rate of septic mice and inhibit inflammation, but whether it has a protective effect on cardiomyopathy (SCM) is unclear.To investigate Ber ameliorates SCM in rat model its potential mechanism.Male SD rats were randomly divided into three groups: control (Con, n = 6) (DD H2O, 2 mL/100 g, ig, qd × 3 d, then saline, 10 mg/kg, ip); sepsis [LPS (lipopolysaccharide), 18] (LPS mg/kg instead berberine intervention (Ber, 18) 50 DD LPS ip). Hemodynamics, HE...

10.1080/13880209.2021.1877736 article EN cc-by Pharmaceutical Biology 2021-01-01

Bladder cancer(BC)is one of the most common urinary system tumors, which characterized by a high incidence. Polyporus polysaccharide is main active component polyporus, clinically used in treatment bladder cancer, but mechanism not clear. In previous study, we isolated homogeneous polyporus polysaccharide(HPP) with purity from polyporus. The goal this study was to assess polarization macrophages induced HPP tumor microenvironment and explored its anti-bladder cancer through BBN rat model...

10.3389/fimmu.2022.839460 article EN cc-by Frontiers in Immunology 2022-05-04

Dyslipidemia in pregnancy are associated with risk of adverse outcomes. As an outcome, small-for-gestational-age has been extensively studied Western countries. However, similar studies have rarely conducted Asian Data were derived from 5695 pairs non-diabetic mothers and neonates between 1 Jan 2014 31 Dec 2014. 5.6% our study SGA. Serum samples collected during second third trimesters for evaluation on fasting lipids levels. The present intended to explore the associations maternal lipid...

10.1038/s41598-020-76845-1 article EN cc-by Scientific Reports 2020-11-16

Although Tongguan capsule (TGC) is used in the treatment of coronary atherosclerotic disease, exact mechanism remains unclear.Network pharmacology and experimental validation were applied to examine TGC for treating myocardial ischemia-reperfusion injury (MIRI).The components candidate targets searched based on various databases such as TCMSP, TCMID, BATMAN-TCM. The binding ability was determined by molecular docking. (I/R) model constructed ligating left anterior descending (LAD) artery....

10.1080/13880209.2023.2175877 article EN cc-by Pharmaceutical Biology 2023-02-15

Heat events increase the risk of preterm birth (PTB), and identifying risk-related event thresholds contributes to developing early warning system for pregnant women guiding their public health response. However, that cause remain unclear. We aimed investigate effects heat defined with different intensities durations on PTB throughout pregnancy, determine high-risk events.Using a population-based cohort data, we included 210,798 singleton live births in eight provinces China during...

10.1016/j.lanwpc.2023.100785 article EN cc-by-nc-nd The Lancet Regional Health - Western Pacific 2023-05-19

<abstract abstract-type="Summary"> <sec> <b>What is already known about this topic?</b> Climate change has had a detrimental impact on global health, particularly through the rise of extreme heatwaves. Presently, early warning system for heatwave-related health risks can forecast potential dangers several days in advance; however, long-term warnings fall short. </sec><sec> added by report?</b> This report introduces novel aimed at predicting heatwave-induced China sub-seasonal to seasonal...

10.46234/ccdcw2023.124 article EN cc-by Deleted Journal 2023-01-01

Objective: Shufeng Jiedu capsule (SFJDC) is a well-known Chinese patent drug that recommended as basic prescription and applied widely in the clinical treatment of COVID-19. However, exact molecular mechanism SFJDC remains unclear. The present study aims to determine potential pharmacological mechanisms COVID-19 based on network pharmacology. Methods: pharmacology-based strategy includes collection analysis active compounds target genes, construction, identification key hub KEGG GO...

10.2174/1386207323999201029122301 article EN Combinatorial Chemistry & High Throughput Screening 2020-11-03

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the leading cause of disease-2019 (COVID-19), is an emerging global health crisis. Lung cancer patients are at a higher risk COVID-19 infection. With increasing number non-small-cell lung (NSCLC) with COVID-19, there urgent need efficacious drugs for treatment COVID-19/NSCLC. Methods: Based on comprehensive bioinformatic and systemic biological analysis, this study investigated COVID-19/NSCLC interactional hub genes,...

10.3389/fphar.2022.857730 article EN cc-by Frontiers in Pharmacology 2022-06-02
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